Journal ArticleDOI
The Haplotype Structure of the Human Major Histocompatibility Complex
Chester A. Alper,Chester A. Alper,Charles E. Larsen,Charles E. Larsen,Devendra P. Dubey,Zuheir L. Awdeh,Dolores A. Fici,Edmond J. Yunis,Edmond J. Yunis +8 more
TLDR
The results suggest that the human genome, including the major histocompatibility complex (MHC), consists largely of 5- to 200-kb blocks of sequence fixity between which random recombination occurs, and the use of statistical analysis rather than direct haplotype determination and counting fails to reveal the details of haplotype structure essential for gene localization.About:
This article is published in Human Immunology.The article was published on 2006-01-01. It has received 105 citations till now. The article focuses on the topics: Tag SNP & Haplotype.read more
Citations
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Journal ArticleDOI
Type 1 Diabetes
TL;DR: Current progress in epidemiology, pathology, diagnosis, and treatment of type 1 diabetes, and prospects for an improved future for individuals with this disease are discussed.
Type 1 diabetes
TL;DR: In this paper, the authors give an overview of the current understanding of Type 1 diabetes and potential future directions for research and care, and discuss the current state of the art in this area.
Journal ArticleDOI
Detecting shared pathogenesis from the shared genetics of immune-related diseases
TL;DR: It is discussed how identifying new genes that are associated with more than one autoimmune or chronic inflammatory disorder could explain the genetic basis of the shared pathogenesis of immune-related diseases.
Journal ArticleDOI
Genetic Data Analysis: Methods for Discrete Population Genetic Data
Journal ArticleDOI
Next-generation sequencing: the solution for high-resolution, unambiguous human leukocyte antigen typing
Curt Lind,Deborah Ferriola,Kate Mackiewicz,S. Heron,Marianne Rogers,Larissa Slavich,Rita Walker,T. Hsiao,Laura McLaughlin,Monica D’Arcy,Xiaowu Gai,Damian Goodridge,David Sayer,Dimitri S. Monos,Dimitri S. Monos +14 more
TL;DR: The results suggest NGS can provide complete, unambiguous, high-resolution HLA typing and can be a useful tool for complete genomic characterization of new HLA alleles and for completion of sequence for existing, partially sequenced alleles.
References
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Journal ArticleDOI
The Structure of Haplotype Blocks in the Human Genome
Stacey Gabriel,Stephen F. Schaffner,Huy Nguyen,Jamie Moore,Jessica Roy,Brendan Blumenstiel,John M. Higgins,Matthew DeFelice,Amy L. Lochner,Maura Faggart,Shau Neen Liu-Cordero,Charles N. Rotimi,Adebowale Adeyemo,Richard S. Cooper,Ryk Ward,Eric S. Lander,Mark J. Daly,David Altshuler,David Altshuler +18 more
TL;DR: It is shown that the human genome can be parsed objectively into haplotype blocks: sizable regions over which there is little evidence for historical recombination and within which only a few common haplotypes are observed.
Book
The Genetic Basis of Evolutionary Change
TL;DR: A new book that many people really want to read will you be one of them? Of course, you should be as discussed by the authors, even some people think that reading is a hard to do, you must be sure that you can do it.
Journal ArticleDOI
The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models.
TL;DR: The results of these investigations were sufficient to show that even for relatively simple cases (two loci, simple symmetrical selective values) linkage might have profound effects on the course of natural selection and, pari passu, natural selection may have major effect on the distribution of coupling and repulsion linkage in a population.
Journal ArticleDOI
High-resolution haplotype structure in the human genome.
Mark J. Daly,John D. Rioux,Stephen F. Schaffner,Thomas J. Hudson,Thomas J. Hudson,Eric S. Lander +5 more
TL;DR: A high-resolution analysis of the haplotype structure across 500 kilobases on chromosome 5q31 using 103 single-nucleotide polymorphisms (SNPs) in a European-derived population offers a coherent framework for creating a haplotype map of the human genome.
Book
Genetic data analysis II : methods for discrete population genetic data
TL;DR: The second edition of "Genetic Data Analysis" as discussed by the authors details the statistical methodology needed to draw inferences from discrete genetic data, including methods to locate human disease genes, and a new chapter on individual identification.
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