Mechanics and Buckling of Biopolymeric Shells and Cell Nuclei
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TLDR
The interior contents of the shell can alter mechanical response and buckling, which is shown by simulating a model for the nucleus that quantitatively agrees with micromanipulation experiments stretching individual nuclei.About:
This article is published in Biophysical Journal.The article was published on 2017-10-17 and is currently open access. It has received 44 citations till now. The article focuses on the topics: Shell (structure) & Buckling.read more
Citations
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Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins
Andrew D. Stephens,Patrick Z. Liu,Edward J. Banigan,Edward J. Banigan,Luay M. Almassalha,Vadim Backman,Stephen A. Adam,Robert D. Goldman,John F. Marko +8 more
TL;DR: Chromatin decompaction via increasing euchromatin or decreasing heterochromatin results in a softer nucleus and abnormal nuclear blebbing, independent of lamin perturbations, and rescuing nuclear morphology in lamin-perturbed cells that present abnormal nuclear morphology.
Journal ArticleDOI
Chromosome Conformation Capture and Beyond: Toward an Integrative View of Chromosome Structure and Function.
TL;DR: A review of chromosome conformation capture methods can be found in this paper, focusing on the contribution of complementary methodologies to our understanding of structures revealed by 3C methods and their biological implications and discuss the next technical and conceptual frontiers.
Journal ArticleDOI
Chromatin’s physical properties shape the nucleus and its functions
TL;DR: These findings reveal how chromatin's physical properties can regulate cellular function and drive abnormal nuclear morphology and dysfunction in disease.
Journal ArticleDOI
Mechanical principles of nuclear shaping and positioning.
TL;DR: Current literature on the sources and magnitude of cellular forces exerted on the nucleus, the nuclear envelope proteins involved in transferring cellular forces, and the contribution of different nuclear structural components to the mechanical response of the nucleus to these forces are reviewed.
Journal ArticleDOI
Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation.
Andrew D. Stephens,Patrick Z. Liu,Viswajit Kandula,Haimei Chen,Luay M. Almassalha,Cameron Herman,Vadim Backman,Thomas V. O'Halloran,Stephen A. Adam,Robert D. Goldman,Edward J. Banigan,Edward J. Banigan,John F. Marko +12 more
TL;DR: It is reported that increased extracellular multivalent cations lead to increased heterochromatin levels through activation of mechanosensitive ion channels (MSCs) and consequent changes to histone modification state and chromatin-based nuclear rigidity, which protects nuclear morphology and function.
References
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Book
Computer Simulation of Liquids
Michael P. Allen,D. J. Tildesley +1 more
TL;DR: In this paper, the gear predictor -corrector is used to calculate forces and torques in a non-equilibrium molecular dynamics simulation using Monte Carlo methods. But it is not suitable for the gear prediction problem.
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Theory of elasticity
TL;DR: The theory of the slipline field is used in this article to solve the problem of stable and non-stressed problems in plane strains in a plane-strain scenario.
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The physics of liquid crystals
P. G. de Gennes,Richard Alben +1 more
TL;DR: In this paper, the authors define an order parameter statistical theories of the nematic order phenomonological description of the nematic-isotopic mixtures and describe the properties of these mixtures.
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Theory of elasticity
TL;DR: The equilibrium of rods and plates Elastic waves Dislocations Thermal conduction and viscosity in solids Mechanics of liquid crystals Index as discussed by the authors The equilibrium of rod and plate elastic waves Elastic waves
Journal ArticleDOI
Polymersomes: tough vesicles made from diblock copolymers.
Bohdana M. Discher,You-Yeon Won,David S. Ege,James C. Lee,Frank S. Bates,Dennis E. Discher,Daniel A. Hammer +6 more
TL;DR: The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry, and both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements.