Journal ArticleDOI
Mice Deficient for the Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase CD38 Exhibit Altered Humoral Immune Responses
Debra A. Cockayne,Tony Muchamuel,J C Grimaldi,Hélène Muller-Steffner,Troy D. Randall,Frances E. Lund,Robin M. Murray,Francis Schuber,Maureen Howard +8 more
TLDR
It is shown that CD38 is not required for hematopoietic stem cells as well as on committed progenitors, and in vivo physiological function(s) of this novel class of ectoenzyme are investigated, suggesting thatCD38 may play an important role in vivo in regulating humoral immune responses.About:
This article is published in Blood.The article was published on 1998-08-15. It has received 218 citations till now. The article focuses on the topics: NAD+ kinase & NAD+ nucleosidase.read more
Citations
More filters
Journal ArticleDOI
Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology
Fabio Malavasi,Silvia Deaglio,Ada Funaro,Enza Ferrero,Alberto L. Horenstein,Erika Ortolan,Tiziana Vaisitti,Semra Aydin +7 more
TL;DR: CD38 is a powerful disease marker for human leukemias and myelomas, is directly involved in the pathogenesis and outcome of human immunodeficiency virus infection and chronic lymphocytic leukemia, and controls insulin release and the development of diabetes.
Journal ArticleDOI
Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo
Santiago Partida-Sanchez,Debra A. Cockayne,Simon Monard,Elaine L. Jacobson,Norman J. Oppenheimer,Beth A. Garvy,Kim Kusser,Stephen Goodrich,Maureen Howard,Allen G. Harmsen,Troy D. Randall,Frances E. Lund +11 more
TL;DR: It is demonstrated that neutrophil chemotaxis to bacterial chemoattractants is dependent on Ca++ mobilization mediated by cyclic ADP-ribose, and CD38 acts as a critical regulator of inflammation and innate immune responses.
Journal ArticleDOI
Lyn tyrosine kinase: accentuating the positive and the negative.
TL;DR: The outcomes of altered Lyn activity within the framework of B cell development and differentiation and the circumstances that appear to dictate the outcome are reviewed.
Journal ArticleDOI
New functions of a long-known molecule. Emerging roles of NAD in cellular signaling.
TL;DR: The first group of reactions leads to the synthesis of an unusual cyclic nucleotide, cyclic ADP-ribose (cADPR), which has been reported to be potent intracellular calcium-mobilizing agents and in concert with inositol 1,4,5-trisphosphate, they participate in cytosolic calcium regulation by releasing calcium from intrace cellular stores.
Journal ArticleDOI
Regulation of intracellular levels of NAD: a novel role for CD38.
TL;DR: Tissue levels of NAD in CD38 deficient mice are 10- to 20-fold higher than in wild-type animals, and NADase activity in the plasma membrane, mitochondria, sarcoplasmic reticulum, and nuclei is essentially absent, which support the novel concept that CD38 is a major regulator of cellular NAD levels.
References
More filters
Journal ArticleDOI
Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage
TL;DR: It is suggested that is it now possible to define stages of T-cell differentiation that can be related to T- cell malignancies in humans.
Journal ArticleDOI
Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells.
TL;DR: Direct evidence is provided for the existence of a single class of progenitors with extensive proliferative capacity in human BM and an experimental approach for their purification, manipulation, and further characterization is provided.
Journal ArticleDOI
T Cell-Independent Antigens Type 2
TL;DR: Evidence demonstrating that B cell activation via TI stimuli does not play merely a permissive role in allowing for cell cycle entry and enhanced responsiveness to other stimuli is presented, rather, the nature of the B cell activating signal is critical in determining the quantitative and qualitative profile of Ig isotype production.
Journal ArticleDOI
Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38
Maureen Howard,J C Grimaldi,J. F. Bazan,Frances E. Lund,Leopoldo Santos-Argumedo,R. M. E. Parkhouse,Timothy F. Walseth,Hon Cheung Lee +7 more
TL;DR: Soluble CD38 catalyzed the formation and hydrolysis of cadPR when added to NAD+.
Journal ArticleDOI
The role of helper T cell products in mouse B cell differentiation and isotype regulation.
Robert L. Coffman,Brian W. P. Seymour,Deborah A. Lebman,Debra D. Hiraki,Judy A. Christiansen,B Shrader,Holly M. Cherwinski,Huub F. J. Savelkoul,Fred D. Finkelman,Martha W. Bond,Tim R. Mosmann +10 more
TL;DR: In this article, the authors summarize the efforts to define the specific helper T cells or lymphokines which transmit regulatory signals to B cells, and to clarify the individual events influenced by these signals.
Related Papers (5)
Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation.
David A. Jackson,John I. Bell +1 more