MicroRNA in cardiovascular biology and disease.
TLDR
In this paper, a review discusses emerging functions of miRNAs in cardiogenesis, heart regeneration and the pathophysiology of cardiovascular diseases, including myocardial infarction, hypertrophy, fibrosis, heart failure, arrhythmia, inflammation and atherosclerosis.Abstract:
MicroRNAs (miRNAs) are members of a non-coding RNA family. They act as negative regulators of protein translation by affecting messenger RNA (mRNA) stability; they modulate numerous signaling pathways and cellular processes, and are involved in cell-to-cell communication. Thus, studies on miRNAs offer an opportunity to improve our understanding of complex biological mechanisms. In the cardiovascular system, miRNAs control functions of various cells, such as cardiomyocytes, endothelial cells, smooth muscle cells and fibroblasts. The pivotal role of miRNAs in the cardiovascular system provides a new perspective on the pathophysiology of disorders like myocardial infarction, hypertrophy, fibrosis, heart failure, arrhythmia, inflammation and atherosclerosis. MiRNAs are differentially expressed in diseased tissue and can be released into circulation. Manipulation of miRNA activity may influence the course of a disease. Therefore, miRNAs have become an active field of research for developing new diagnostic and therapeutic tools. This review discusses emerging functions of miRNAs in cardiogenesis, heart regeneration and the pathophysiology of cardiovascular diseases.read more
Citations
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Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles
Massimo Bonora,Mariusz R. Wieckowski,David A. Sinclair,Guido Kroemer,Paolo Pinton,Lorenzo Galluzzi +5 more
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MicroRNAs in Cardiac Diseases.
TL;DR: This review summarizes and updates microRNAs playing a role in the different processes underlying the pathogenic phenotypes of cardiac muscle and highlights their potential role as disease biomarkers and therapeutic targets.
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Inhibition of circHIPK3 prevents angiotensin II-induced cardiac fibrosis by sponging miR-29b-3p
TL;DR: The data suggest that circHIPK3 serves as a miR-29b-3p sponge to regulate CF proliferation, migration and development of cardiac fibrosis, revealing a potential new target for the prevention of Ang II-induced cardiac fibrot.
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Recent Advances in miRNA Delivery Systems
TL;DR: In this paper, the strengths and weaknesses of current state-of-the-art viral and non-viral miRNA delivery systems and how these tools can be exploited to improve the outcomes of miRNA-based therapeutics.
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Oxidative Stress-Responsive MicroRNAs in Heart Injury.
Branislav Kura,Barbara Szeiffova Bacova,Barbora Kalocayova,Matus Sykora,Matus Sykora,Jan Slezak +5 more
TL;DR: The need for studying the role of redox-sensitive miRNAs is pointed to to identify more effective biomarkers and develop better therapeutic targets for oxidative-stress-related heart diseases.
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