MicroRNA in Cervical Cancer: OncomiRs and Tumor Suppressor miRs in Diagnosis and Treatment
Kouji Banno,Miho Iida,Megumi Yanokura,Iori Kisu,Takashi Iwata,Eiichiro Tominaga,Kyoko Tanaka,Daisuke Aoki +7 more
TLDR
Methods for diagnosis of cervical cancer include analysis of changes in the levels of specific miRNAs in serum and determination of aberrant hypermethylation of miRN as well as an anti-miR-21 inhibitor developed.Abstract:
Cervical cancer is a female-specific disease with a high incidence and mortality. MicroRNAs (miRNAs) are implicated in posttranscriptional regulation of gene expression and in the pathogenic mechanisms of cancer, suggesting their importance in diagnosis and treatment. miRNAs may have roles in the pathogenesis of cervical cancer based on the increases or decreases in several specific miRNAs found in patients with this disease. The miRNAs implicated in cervical cancer are miR-21, miR-126, and miR-143, and clinical application of these miRNAs for diagnosis and treatment is under investigation. Methods for diagnosis of cervical cancer include analysis of changes in the levels of specific miRNAs in serum and determination of aberrant hypermethylation of miRNAs. Supplementation of miR-143 or inhibition of miR-21 activity in vivo may be therapeutic strategy for cervical cancer. Previous approaches to development of siRNA as a drug have provided information for establishment of therapy based on these approaches, and an anti-miR-21 inhibitor has been developed. miRNAs also have effects on drug resistance and may be useful in combination therapy with other drugs.read more
Citations
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LncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR.
Jiyoung Kim,Kotb Abdelmohsen,Xiaoling Yang,Supriyo De,Ioannis Grammatikakis,Ji Heon Noh,Myriam Gorospe +6 more
TL;DR: It is proposed that OIP5-AS1 serves as a sponge or a competing endogenous (ce)RNA for HuR, restricting its availability to HuR target mRNAs and thereby repressing HuR-elicited proliferative phenotypes.
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microRNAs: New prognostic, diagnostic, and therapeutic biomarkers in cervical cancer.
Javid Sadri Nahand,Sima Taghizadeh-Boroujeni,Mohammad Karimzadeh,Sarina Borran,Mohammad Hossein Pourhanifeh,Mohsen Moghoofei,Farah Bokharaei-Salim,Sajad Karampoor,Amir Jafari,Zatollah Asemi,Alireza Tbibzadeh,Afshin Namdar,Hamed Mirzaei +12 more
TL;DR: Various miRNAs are summarized as an employable platform for prognostic, diagnostic, and therapeutic biomarkers in the treatment of cervical cancer.
Journal ArticleDOI
MiR-125a suppresses tumor growth, invasion and metastasis in cervical cancer by targeting STAT3.
Zhongyi Fan,Hanzhi Cui,Xiaojie Xu,Zhi Lin,Xuelin Zhang,Lei Kang,Baiyu Han,Jing Meng,Zhifeng Yan,Xiang Yan,Shunchang Jiao +10 more
TL;DR: The expression of miR-125a was downregulated in cervical cancer patients, and negatively correlated with the tumor size, FIGO stage, and preoperative metastasis, and Clinically, STAT3, the expression of which, predicted poorer outcome, was inversely correlated with miR -125a in cervicalcancer.
Journal ArticleDOI
miR-342-3p suppresses proliferation, migration and invasion by targeting FOXM1 in human cervical cancer.
TL;DR: It is reported that FOXM1 is directly targeted by miR‐342‐3p, which is down‐regulated along with its host gene, EVL, in human cervical cancer tissues compared to the adjacent normal tissues.
Journal ArticleDOI
The role of MicroRNAs expression in laryngeal cancer
TL;DR: In this review, a summary of the recent researches on laryngeal cancer-associated miRs is summarized, focusing on their role in the pathogenesis of larynGEal cancer.
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