Journal ArticleDOI
Milk-derived exosomes for oral delivery of paclitaxel
Ashish Kumar Agrawal,Farrukh Aqil,Jeyaprakash Jeyabalan,Wendy A. Spencer,Joshua Beck,Beth W. Gachuki,Sara S. Alhakeem,Karine Z. Oben,Radha Munagala,Subbarao Bondada,Ramesh C. Gupta +10 more
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TLDR
In this article, milk-derived exosomes have been investigated for oral delivery of the chemotherapeutic drug paclitaxel (PAC) as an alternative to conventional i.p. therapy for improved efficacy and reduced toxicity.About:
This article is published in Nanomedicine: Nanotechnology, Biology and Medicine.The article was published on 2017-07-01. It has received 329 citations till now.read more
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Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications
TL;DR: The origin, classification, preparation and characterization, storage stability and applications of exosome delivery system are summarized and discussed by searching a large number of literatures to optimize the above problems and facilitate future functional studies of exOSomes.
Journal ArticleDOI
Recent advancements in the use of exosomes as drug delivery systems.
TL;DR: A review of both exosomes derived from various cells and modified exosome and their ability in delivering the many kinds of cargo to the target cell is provided in this paper.
Journal ArticleDOI
Application of exosomes as liquid biopsy in clinical diagnosis.
TL;DR: This work investigates publication frequencies on exosomes over the past 10 years, and reviews recent clinical studies on liquid biopsy of exosome in the fields of oncology, pregnancy disorders, cardiovascular diseases, and organ transplantation.
Recent advancements in the use of exosomes as drug delivery systems 06 Biological Sciences 0601 Biochemistry and Cell Biology
TL;DR: This article provides a review of both exosomes derived from various cells and modified exosome and their ability in delivering the many kinds of cargo to the target cell.
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Preservation and Storage Stability of Extracellular Vesicles for Therapeutic Applications
Anjana Jeyaram,Steven M. Jay +1 more
TL;DR: Current knowledge in the field of EV preservation and storage stability is reported and future directions in the area that could be critical to eventual development of EV therapies are highlighted.
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Journal ArticleDOI
Oral paclitaxel chemotherapy for brain tumors: ideal combination treatment of paclitaxel and P-glycoprotein inhibitor.
Kyeung Min Joo,Kwan Park,Doo-Sik Kong,Sang Yong Song,Mi Hyun Kim,Gwan Sun Lee,Maeng Sup Kim,Do-Hyun Nam +7 more
TL;DR: If the doses and dose ratio can be successfully adjusted, the oral co-administration of HM30181A and paclitaxel can be used to treat tumors in the brain.
Journal Article
Mobilization of peripheral blood progenitor cells with paclitaxel-based chemotherapy.
TL;DR: Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) causes no thrombocytopenia or cumulative hematopoietic toxicity and was found to effectively mobilize PBPCs without damaging the stem cell pool.
Journal ArticleDOI
Successful mobilization of hematopoietic peripheral blood progenitor cells with paclitaxel-based chemotherapy as initial or salvage regimen in patients with hematologic malignancies.
Angel Fernández,Felipe de Arriba,José Rivera,Inmaculada Heras,Vicente Vicente,Maria Luisa Lozano +5 more
TL;DR: Autologous hematopoietic progenitor cell transplantation is a standard of care in several hematologic diseases, but many patients are unable to mobilize a sufficient number of cells for transplantation.