Journal ArticleDOI
Milk-derived exosomes for oral delivery of paclitaxel
Ashish Kumar Agrawal,Farrukh Aqil,Jeyaprakash Jeyabalan,Wendy A. Spencer,Joshua Beck,Beth W. Gachuki,Sara S. Alhakeem,Karine Z. Oben,Radha Munagala,Subbarao Bondada,Ramesh C. Gupta +10 more
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TLDR
In this article, milk-derived exosomes have been investigated for oral delivery of the chemotherapeutic drug paclitaxel (PAC) as an alternative to conventional i.p. therapy for improved efficacy and reduced toxicity.About:
This article is published in Nanomedicine: Nanotechnology, Biology and Medicine.The article was published on 2017-07-01. It has received 329 citations till now.read more
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New Advances in Exosome-based Targeted Drug Delivery Systems.
TL;DR: In this article , a review of exosome biogenesis, contents, forms of isolation and their natural functions is discussed, further complemented with the various successful methodologies for therapeutic payloads encapsulation, including distinct loading approaches.
Journal ArticleDOI
Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications
Ala H. Amiri,Rafieh Bagherifar,Ehsan Ansari Dezfouli,Seyed Hossein Kiaie,Reza Jafari,Reihaneh Ramezani +5 more
TL;DR: In this paper , the authors take a look at the unique features of exosomes and their isolation and loading methods, to embrace this idea that exosome-mediated mRNA-based therapies would be introduced as a very efficient strategy in disease treatment within the near future.
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Exosomes: Multiple-targeted multifunctional biological nanoparticles in the diagnosis, drug delivery, and imaging of cancer cells.
Yuzhong Zheng,Anwarul Hasan,Mohammad Mahdi Nejadi Babadaei,Elham Behzadi,Mina Nouri,Majid Sharifi,Majid Sharifi,Mojtaba Falahati +7 more
TL;DR: This review attempts to provide an appropriate incentive by showing the performance of exosomes in cancer therapy through targeted drug delivery, gene therapy, imaging and diagnosis by showing their high loading, stability and longer circulation time, excellent targeting, high cell penetration performance, and optimal biodegradation.
Journal ArticleDOI
Nanomedicine for increasing the oral bioavailability of cancer treatments.
Alessandro Parodi,Polina Buzaeva,Daria Nigovora,Alexey V. Baldin,Dmitry Kostyushev,Vladimir Chulanov,Lyudmila V. Savvateeva,Andrey A. Zamyatnin +7 more
TL;DR: In this paper, a review describes the properties of several nanodelivery systems that improve the bioavailability of orally administered therapeutics, highlighting their advantages and disadvantages in generating successful anticancer oral nanomedicines.
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Extracellular vesicles as delivery systems at nano-/micro-scale
TL;DR: Extracellular vesicles (EVs) have shown significant promises as nano-/micro-size carriers in drug delivery and bioimaging as mentioned in this paper, and their unmatched physicochemical properties, biological features, and mechanical aspects make them unique vehicles, owning exceptional pharmacokinetics, circulatory metabolism and biodistribution pattern when delivering theranostic cargoes.
References
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Journal ArticleDOI
Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer
William J. Gradishar,Sergei Tjulandin,Neville Davidson,Heather S. Shaw,Neil Desai,P. Bhar,Michael M. Hawkins,Joyce O'Shaughnessy +7 more
TL;DR: The improved therapeutic index and elimination of corticosteroid premedication required for solvent-based taxanes make the novel albumin-bound paclitaxel ABI-007 an important advance in the treatment of MBC.
Journal ArticleDOI
Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation.
TL;DR: With the present development of various new anticancer agents, it is recommended that alternative formulation approaches should be pursued to allow a better control of the toxicity of the treatment and the pharmacological interactions related to the use of CrEL.
Journal ArticleDOI
Acidity generated by the tumor microenvironment drives local invasion
Veronica Estrella,Tingan Chen,Mark C. Lloyd,Jonathan W. Wojtkowiak,Heather H. Cornnell,Arig Ibrahim-Hashim,Kate M. Bailey,Yoganand Balagurunathan,Jennifer M. Rothberg,Bonnie F. Sloane,Joseph O. Johnson,Robert A. Gatenby,Robert J. Gillies +12 more
TL;DR: Oral administration of sodium bicarbonate was sufficient to increase peritumoral pH and inhibit tumor growth and local invasion in a preclinical model, supporting the acid-mediated invasion hypothesis.
Journal ArticleDOI
Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells
Myung Soo Kim,Matthew J. Haney,Yuling Zhao,Vivek Mahajan,I.M. Deygen,Natalia L. Klyachko,Natalia L. Klyachko,Eli Inskoe,Aleksandr Piroyan,Marina Sokolsky,Onyi Okolie,Shawn Hingtgen,Alexander V. Kabanov,Alexander V. Kabanov,Elena V. Batrakova +14 more
TL;DR: A exosome-based system to carry formulation of PTX was developed and showed efficacy in the treatment of multi-drug resistant cancer cells and this novel system may be further developed to carry other chemotherapeutic agents in the future.