Journal ArticleDOI
Milk-derived exosomes for oral delivery of paclitaxel
Ashish Kumar Agrawal,Farrukh Aqil,Jeyaprakash Jeyabalan,Wendy A. Spencer,Joshua Beck,Beth W. Gachuki,Sara S. Alhakeem,Karine Z. Oben,Radha Munagala,Subbarao Bondada,Ramesh C. Gupta +10 more
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TLDR
In this article, milk-derived exosomes have been investigated for oral delivery of the chemotherapeutic drug paclitaxel (PAC) as an alternative to conventional i.p. therapy for improved efficacy and reduced toxicity.About:
This article is published in Nanomedicine: Nanotechnology, Biology and Medicine.The article was published on 2017-07-01. It has received 329 citations till now.read more
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Research progress of exosomes as drug carriers in cancer and inflammation
TL;DR: In this paper , the authors reviewed the most up-to-date research progress of exosomes as carriers for nucleic acids, proteins and small molecule drugs for cancer and inflammation management.
Journal ArticleDOI
Milk-derived exosomes as a promising vehicle for oral delivery of hydrophilic biomacromolecule drugs.
Yuting Li,Liyun Xing,Lingling Wang,Xi Liu,Licheng Wu,Mingjie Ni,Zhou Zhou,Lian Li,Xiu-Ran Liu,Yuan Huang +9 more
TL;DR: In this paper , the effects of drug loading methods and physicochemical properties (lipophilicity and molecular weight) on drug loading efficiency of milk-derived exosomes to explore the most appropriate loading conditions.
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The use of exosome carrier to augmentation of Helicobacter pylori infection treatment
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Drug target therapy and emerging clinical relevance of exosomes in meningeal tumors
TL;DR: The role of exosomes in the treatment of different types of cancer including meningioma has been investigated in this article , where a wide variety of chemotherapeutic drugs and molecular targeted drugs such as tyrosine kinase inhibitors, alkylating agents, endocrine drugs, interferon and targeted molecular pathway inhibitors have been studied.
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Perspectives of bovine and human milk exosomics as health biomarkers for advancing systemic therapeutic potential
TL;DR: The epithelial cells of the mammary gland secrete extracellular nanoveicles known as exosomes that carry and protect microRNAs and other various signaling biomolecules as discussed by the authors.
References
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Journal ArticleDOI
Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer
William J. Gradishar,Sergei Tjulandin,Neville Davidson,Heather S. Shaw,Neil Desai,P. Bhar,Michael M. Hawkins,Joyce O'Shaughnessy +7 more
TL;DR: The improved therapeutic index and elimination of corticosteroid premedication required for solvent-based taxanes make the novel albumin-bound paclitaxel ABI-007 an important advance in the treatment of MBC.
Journal ArticleDOI
Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation.
TL;DR: With the present development of various new anticancer agents, it is recommended that alternative formulation approaches should be pursued to allow a better control of the toxicity of the treatment and the pharmacological interactions related to the use of CrEL.
Journal ArticleDOI
Acidity generated by the tumor microenvironment drives local invasion
Veronica Estrella,Tingan Chen,Mark C. Lloyd,Jonathan W. Wojtkowiak,Heather H. Cornnell,Arig Ibrahim-Hashim,Kate M. Bailey,Yoganand Balagurunathan,Jennifer M. Rothberg,Bonnie F. Sloane,Joseph O. Johnson,Robert A. Gatenby,Robert J. Gillies +12 more
TL;DR: Oral administration of sodium bicarbonate was sufficient to increase peritumoral pH and inhibit tumor growth and local invasion in a preclinical model, supporting the acid-mediated invasion hypothesis.
Journal ArticleDOI
Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells
Myung Soo Kim,Matthew J. Haney,Yuling Zhao,Vivek Mahajan,I.M. Deygen,Natalia L. Klyachko,Natalia L. Klyachko,Eli Inskoe,Aleksandr Piroyan,Marina Sokolsky,Onyi Okolie,Shawn Hingtgen,Alexander V. Kabanov,Alexander V. Kabanov,Elena V. Batrakova +14 more
TL;DR: A exosome-based system to carry formulation of PTX was developed and showed efficacy in the treatment of multi-drug resistant cancer cells and this novel system may be further developed to carry other chemotherapeutic agents in the future.