Journal ArticleDOI
Milk-derived exosomes for oral delivery of paclitaxel
Ashish Kumar Agrawal,Farrukh Aqil,Jeyaprakash Jeyabalan,Wendy A. Spencer,Joshua Beck,Beth W. Gachuki,Sara S. Alhakeem,Karine Z. Oben,Radha Munagala,Subbarao Bondada,Ramesh C. Gupta +10 more
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TLDR
In this article, milk-derived exosomes have been investigated for oral delivery of the chemotherapeutic drug paclitaxel (PAC) as an alternative to conventional i.p. therapy for improved efficacy and reduced toxicity.About:
This article is published in Nanomedicine: Nanotechnology, Biology and Medicine.The article was published on 2017-07-01. It has received 329 citations till now.read more
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Suppression of anti-tumor immunity in chronic lymphocytic leukemia via interleukin-10 production
TL;DR: It is demonstrated that CLL cells suppress host anti-tumor immunity via IL-10 production, and a novel role of B-cell receptor (BCR) signaling pathway in constitutive IL- 10 secretion is found.
Journal ArticleDOI
An update in the applications of exosomes in cancer theranostics: from research to clinical trials
Kourosh Shahraki,Paria Ghasemi Boroumand,Hajie Lotfi,Fatemeh Radnia,Hossein Ali Shahriari,Saman Sargazi,Sedigheh Sadat Mortazavi,Milad Shirvaliloo,Sakine Shirvalilou,Roghayeh Sheervalilou +9 more
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Small extracellular vesicles: a novel drug delivery system for neurodegenerative disorders
TL;DR: In this article , small extracellular vesicles (sEVs) are used for targeted delivery of molecules to specific sites in the brain as a therapeutic vehicle due to their low toxicity, low immunogenicity, high stability, high delivery efficiency, high biocompatibility and trans-BBB functionality.
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Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer
William J. Gradishar,Sergei Tjulandin,Neville Davidson,Heather S. Shaw,Neil Desai,P. Bhar,Michael M. Hawkins,Joyce O'Shaughnessy +7 more
TL;DR: The improved therapeutic index and elimination of corticosteroid premedication required for solvent-based taxanes make the novel albumin-bound paclitaxel ABI-007 an important advance in the treatment of MBC.
Journal ArticleDOI
Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation.
TL;DR: With the present development of various new anticancer agents, it is recommended that alternative formulation approaches should be pursued to allow a better control of the toxicity of the treatment and the pharmacological interactions related to the use of CrEL.
Journal ArticleDOI
Acidity generated by the tumor microenvironment drives local invasion
Veronica Estrella,Tingan Chen,Mark C. Lloyd,Jonathan W. Wojtkowiak,Heather H. Cornnell,Arig Ibrahim-Hashim,Kate M. Bailey,Yoganand Balagurunathan,Jennifer M. Rothberg,Bonnie F. Sloane,Joseph O. Johnson,Robert A. Gatenby,Robert J. Gillies +12 more
TL;DR: Oral administration of sodium bicarbonate was sufficient to increase peritumoral pH and inhibit tumor growth and local invasion in a preclinical model, supporting the acid-mediated invasion hypothesis.
Journal ArticleDOI
Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells
Myung Soo Kim,Matthew J. Haney,Yuling Zhao,Vivek Mahajan,I.M. Deygen,Natalia L. Klyachko,Natalia L. Klyachko,Eli Inskoe,Aleksandr Piroyan,Marina Sokolsky,Onyi Okolie,Shawn Hingtgen,Alexander V. Kabanov,Alexander V. Kabanov,Elena V. Batrakova +14 more
TL;DR: A exosome-based system to carry formulation of PTX was developed and showed efficacy in the treatment of multi-drug resistant cancer cells and this novel system may be further developed to carry other chemotherapeutic agents in the future.