Journal ArticleDOI
Milk-derived exosomes for oral delivery of paclitaxel
Ashish Kumar Agrawal,Farrukh Aqil,Jeyaprakash Jeyabalan,Wendy A. Spencer,Joshua Beck,Beth W. Gachuki,Sara S. Alhakeem,Karine Z. Oben,Radha Munagala,Subbarao Bondada,Ramesh C. Gupta +10 more
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TLDR
In this article, milk-derived exosomes have been investigated for oral delivery of the chemotherapeutic drug paclitaxel (PAC) as an alternative to conventional i.p. therapy for improved efficacy and reduced toxicity.About:
This article is published in Nanomedicine: Nanotechnology, Biology and Medicine.The article was published on 2017-07-01. It has received 329 citations till now.read more
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Combinational Treatment of Bioscaffolds and Extracellular Vesicles in Spinal Cord Injury.
TL;DR: The respective roles of bioscaffolds and exosomes in SCI are explicated, and the usage of combinational therapy involving bioscafolds and extracellular vesicles (EVs) in improving SCI is elucidated.
Journal ArticleDOI
The tremendous biomedical potential of bacterial extracellular vesicles.
TL;DR: Bacterial extracellular vesicles (bEVs) are nano-sized, lipid membrane-delimited particles filled with bacteria-derived components as discussed by the authors , which have important roles in the physiology and pathogenesis of bacteria and in bacteria-bacteria and bacteria-host interactions.
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Avengers against cancer: A new era of nano-biomaterial-based therapeutics
TL;DR: In this paper, the authors discuss the recent advancements in the use of nanoparticle-based drug delivery systems as well as the development of synthetic biodegradable polypeptides and polymers for cancer treatment (both in vivo and in vitro).
Journal ArticleDOI
FBS-Derived Exosomes as a Natural Nano-Scale Carrier for Icariin Promote Osteoblast Proliferation
TL;DR: In this article, the authors used Fetal bovine serum (FBS) exosomes to carry Icariin for the first time in this experiment, FBS exosome-Icariin (fBS EXO-ICA) more effectively promoted the proliferation of osteoblasts and bone regeneration than IcariIN alone.
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Cell Death and Exosomes Regulation After Myocardial Infarction and Ischemia-Reperfusion.
TL;DR: In this article, the authors focused on introducing various cell-derived exosomes to reduce cell death after MI by regulating the cell death pathway to understand myocardial repair mechanisms better and provide a reference for clinical treatment.
References
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Journal ArticleDOI
Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer
William J. Gradishar,Sergei Tjulandin,Neville Davidson,Heather S. Shaw,Neil Desai,P. Bhar,Michael M. Hawkins,Joyce O'Shaughnessy +7 more
TL;DR: The improved therapeutic index and elimination of corticosteroid premedication required for solvent-based taxanes make the novel albumin-bound paclitaxel ABI-007 an important advance in the treatment of MBC.
Journal ArticleDOI
Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation.
TL;DR: With the present development of various new anticancer agents, it is recommended that alternative formulation approaches should be pursued to allow a better control of the toxicity of the treatment and the pharmacological interactions related to the use of CrEL.
Journal ArticleDOI
Acidity generated by the tumor microenvironment drives local invasion
Veronica Estrella,Tingan Chen,Mark C. Lloyd,Jonathan W. Wojtkowiak,Heather H. Cornnell,Arig Ibrahim-Hashim,Kate M. Bailey,Yoganand Balagurunathan,Jennifer M. Rothberg,Bonnie F. Sloane,Joseph O. Johnson,Robert A. Gatenby,Robert J. Gillies +12 more
TL;DR: Oral administration of sodium bicarbonate was sufficient to increase peritumoral pH and inhibit tumor growth and local invasion in a preclinical model, supporting the acid-mediated invasion hypothesis.
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Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells
Myung Soo Kim,Matthew J. Haney,Yuling Zhao,Vivek Mahajan,I.M. Deygen,Natalia L. Klyachko,Natalia L. Klyachko,Eli Inskoe,Aleksandr Piroyan,Marina Sokolsky,Onyi Okolie,Shawn Hingtgen,Alexander V. Kabanov,Alexander V. Kabanov,Elena V. Batrakova +14 more
TL;DR: A exosome-based system to carry formulation of PTX was developed and showed efficacy in the treatment of multi-drug resistant cancer cells and this novel system may be further developed to carry other chemotherapeutic agents in the future.