Movable Hollow Nanoparticles as Reactive Oxygen Scavengers
Meiling Lian,Zhenjie Xue,Xuezhi Qiao,Cong Liu,Shuo Zhang,Xiao Li,Chuanhui Huang,Qian Song,Wensheng Yang,Xu Chen,Tie Wang +10 more
TLDR
An orthogonal approach to guide movable hemin-loaded mesoporous silica nanoparticles for the removal of intracellular ROS and the ability of these movable hollow nanoparticles to scavenge ROS based on the universal nature of this strategy was verified both in vitro and in vivo.About:
This article is published in Chem.The article was published on 2019-09-12 and is currently open access. It has received 65 citations till now. The article focuses on the topics: Mesoporous silica.read more
Citations
More filters
Journal ArticleDOI
Coordination number regulation of molybdenum single-atom nanozyme peroxidase-like specificity
Ying Wang,Guangri Jia,Xiaoqiang Cui,Xiao Zhao,Xiao Zhao,Qinghua Zhang,Lin Gu,Lirong Zheng,Lu Hua Li,Qiong Wu,David J. Singh,Daiju Matsumura,Takuya Tsuji,Yi-Tao Cui,Jingxiang Zhao,Weitao Zheng +15 more
TL;DR: This study demonstrates the rational design of peroxidase-specific nanozymes and precise regulation of their enzymatic properties.
Journal ArticleDOI
2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases.
Wei Feng,Wei Feng,Xiuguo Han,Hui Hu,Hui Hu,Meiqi Chang,Li Ding,Huijing Xiang,Yu Chen,Yu Chen,Yuehua Li +10 more
TL;DR: In this paper, a two-dimensional vanadium carbide (V2C) MXene nanoenzyme (MXenzyme) was constructed to mimic up to six naturally-occurring enzymes, including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione peroxido-oxide (GPx), thiol peroxide (TPx), and haloperoxidases (HPO), which not only possesses high biocompatibility but also exhibits robust in vitro cytoprotection
Journal ArticleDOI
Design of hollow carbon-based materials derived from metal–organic frameworks for electrocatalysis and electrochemical energy storage
TL;DR: In this article, the process of preparing metal-organic frameworks (MOFs) derived hollow carbon-based materials and their applications in electrochemical energy storage and electrocatalysis are reviewed.
Journal ArticleDOI
Self-Protecting Biomimetic Nanozyme for Selective and Synergistic Clearance of Peripheral Amyloid-β in an Alzheimer's Disease Model.
Mengmeng Ma,Mengmeng Ma,Zhenqi Liu,Zhenqi Liu,Nan Gao,Zifeng Pi,Xiubo Du,Jinsong Ren,Jinsong Ren,Xiaogang Qu,Xiaogang Qu +10 more
TL;DR: In vivo studies demonstrate that CuxO@EM-K not only reduces Aβ burden in the blood and brain but also ameliorates memory deficits in the widely used 3xTg-AD mouse model, providing an example for developing biocompatible and synergistic clearance of peripheral Aβ associated with AD.
Journal ArticleDOI
Effect of structure: A new insight into nanoparticle assemblies from inanimate to animate.
TL;DR: This critical review of the properties of NP assemblies, particularly their animate properties, highlights recent advances and discusses the barriers to further advances in this field.
References
More filters
Journal ArticleDOI
Prussian Blue Nanoparticles as Multienzyme Mimetics and Reactive Oxygen Species Scavengers.
TL;DR: Prussian blue nanoparticles (PBNPs) can effectively scavenge ROS via multienzyme-like activity including peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD) activity and are shown to be POD mimetics that can inhibit •OH generation.
Journal ArticleDOI
Autonomous movement of platinum-loaded stomatocytes
TL;DR: An approach to generate autonomous movement of the polymer stomatocytes by selectively entrapping catalytically active platinum nanoparticles within their nanocavities and subsequently using catalysis as a driving force for movement is reported.
Journal ArticleDOI
Incorporating Graphene Oxide and Gold Nanoclusters: A Synergistic Catalyst with Surprisingly High Peroxidase-Like Activity Over a Broad pH Range and its Application for Cancer Cell Detection
TL;DR: A synergistic graphene oxide-gold nanocluster (GO-AuNC) hybrid has been constructed as an enzyme mimic that is able to show high catalytic activity over a broad pH range, especially at neutral pH.
Journal ArticleDOI
Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer's Disease
Hyek Jin Kwon,Moon Yong Cha,Dokyoon Kim,Dong Kyu Kim,Min Soh,Kwangsoo Shin,Taeghwan Hyeon,Inhee Mook-Jung +7 more
TL;DR: The design and synthesis of triphenylphosphonium-conjugated ceria nanoparticles that localize to mitochondria and suppress neuronal death in a 5XFAD transgenic Alzheimer's disease mouse model are reported.
Journal ArticleDOI
A Redox Modulatory Mn3O4 Nanozyme with Multi-Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model
Namrata Singh,Mohammed Azharuddin Savanur,Shubhi Srivastava,Patrick D'Silva,Govindasamy Mugesh +4 more
TL;DR: The redox modulatory effect of Mn3 O4 plays a crucial role in protecting the cells from MPP+ induced cytotoxicity in a Parkinson disease (PD)-like cellular model, indicating that manganese-based nanomaterials having multi-enzyme activity can robustly rescue the Cells from oxidative damage and thereby possess therapeutic potential to prevent ROS-mediated neurological disorders.
Related Papers (5)
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
Hui Wei,Erkang Wang +1 more