Journal ArticleDOI
mTOR complexes in neurodevelopmental and neuropsychiatric disorders
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TLDR
The most recent advances in studies of mTOR signaling in the brain and the possible mechanisms underlying the many different functions of the mTOR complexes in neurological diseases are described and the medical relevance is discussed.Abstract:
The mechanistic target of rapamycin (mTOR) acts as a highly conserved signaling "hub" that integrates neuronal activity and a variety of synaptic inputs. mTOR is found in two functionally distinct complexes, mTORC1 and mTORC2, that crucially control long-term synaptic efficacy and memory storage. Dysregulation of mTOR signaling is associated with neurodevelopmental and neuropsychiatric disorders. In this Review, we describe the most recent advances in studies of mTOR signaling in the brain and the possible mechanisms underlying the many different functions of the mTOR complexes in neurological diseases. In addition, we discuss the medical relevance of these findings.read more
Citations
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Targeting the intracellular signaling "STOP" and "GO" pathways for the treatment of alcohol use disorders.
Dorit Ron,Anthony L. Berger +1 more
TL;DR: This review focuses on examples of the GO and the STOP intracellular signaling pathways and discusses the current knowledge of how manipulations of these pathways may be used for the treatment of AUD.
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Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission.
Danilo De Gregorio,Jelena Popic,Justine P Enns,Antonio Inserra,Agnieszka Skalecka,Athanasios Markopoulos,Luca Posa,Martha Lopez-Canul,He Qianzi,Christopher K. Lafferty,Jonathan P. Britt,Stefano Comai,Stefano Comai,Argel Aguilar-Valles,Nahum Sonenberg,Gabriella Gobbi,Gabriella Gobbi +16 more
TL;DR: In this paper, the effects of LSD on the medial prefrontal cortex (mPFC) and glutamatergic neurotransmission in male mice were studied using a multidisciplinary approach including electrophysiology, optogenetics, behavioral paradigms, and molecular biology.
Journal ArticleDOI
Deletion of mTOR in Reactive Astrocytes Suppresses Chronic Seizures in a Mouse Model of Temporal Lobe Epilepsy
TL;DR: It was demonstrated that mTOR deletion from reactive astrocytes prevents increases in seizure frequency over the disease course, and data indicate that astroCytes with activated mTOR signaling may provide conditions that are favorable for spontaneous recurrent seizures.
Journal ArticleDOI
mTORC1 accelerates retinal development via the immunoproteasome.
Ji-heon Choi,Hong Seok Jo,Soyeon Lim,Hyoung-Tai Kim,Kang Woo Lee,Kyeong Hwan Moon,Taejeong Ha,Sang Soo Kwak,Yeha Kim,Eun Jung Lee,Cheol O. Joe,Jin Woo Kim +11 more
TL;DR: The authors show that mTORC1 promotes progenitor cell cycle progression and hence accelerated development in mouse retina through induction of the immunoproteasome which enhances the degradation of cyclins.
Journal ArticleDOI
Targeting PI3K-AKT/mTOR signaling in the prevention of autism.
Aarti Sharma,Sidharth Mehan +1 more
TL;DR: The PI3K-AKT/mTOR signaling pathway represents an essential signaling mechanism for mammalian enzyme-related receptors in transducing signals or biological processes such as cell development, differentiation, cell survival, protein synthesis, and metabolism as mentioned in this paper.
References
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mTOR Signaling in Growth Control and Disease
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.
Journal ArticleDOI
mTOR signaling in growth control and disease.
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
Journal ArticleDOI
The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses
TL;DR: This book aims to investigate elementary forms of learning and memory at a cellular molecular level—as specific molecular activities within identified nerve cells withinidentified nerve cells.
Journal ArticleDOI
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
TL;DR: Recent advances in understanding of the molecular structures and biochemical functions of the translation initiation machinery are described and key strategies that mediate general or gene-specific translational control are summarized, particularly in mammalian systems.
Journal ArticleDOI
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D. Sarbassov,Siraj M. Ali,Siraj M. Ali,Shomit Sengupta,Shomit Sengupta,Joon Ho Sheen,Joon Ho Sheen,Peggy P. Hsu,Peggy P. Hsu,Alex F. Bagley,Alex F. Bagley,Andrew L. Markhard,Andrew L. Markhard,David M. Sabatini,David M. Sabatini +14 more
TL;DR: It is shown that rapamycin inhibits the assembly of mTORC2 and that, in many cell types, prolongedRapamycin treatment reduces the levels of m TORC2 below those needed to maintain Akt/PKB signaling.
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