Journal ArticleDOI
mTOR complexes in neurodevelopmental and neuropsychiatric disorders
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TLDR
The most recent advances in studies of mTOR signaling in the brain and the possible mechanisms underlying the many different functions of the mTOR complexes in neurological diseases are described and the medical relevance is discussed.Abstract:
The mechanistic target of rapamycin (mTOR) acts as a highly conserved signaling "hub" that integrates neuronal activity and a variety of synaptic inputs. mTOR is found in two functionally distinct complexes, mTORC1 and mTORC2, that crucially control long-term synaptic efficacy and memory storage. Dysregulation of mTOR signaling is associated with neurodevelopmental and neuropsychiatric disorders. In this Review, we describe the most recent advances in studies of mTOR signaling in the brain and the possible mechanisms underlying the many different functions of the mTOR complexes in neurological diseases. In addition, we discuss the medical relevance of these findings.read more
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Familial focal epilepsy with focal cortical dysplasia due to DEPDC5 mutations
Stéphanie Baulac,Saeko Ishida,Elise Marsan,Catherine Miquel,Arnaud Biraben,Dang Khoa Nguyen,Doug Nordli,Patrick Cossette,Sylvie Nguyen,Virginie Lambrecq,Mihaela Vlaicu,Mailys Daniau,Franck Bielle,Eva Andermann,Eva Andermann,Frederick Andermann,Frederick Andermann,Eric LeGuern,Francine Chassoux,Fabienne Picard +19 more
TL;DR: The role of DEPDC5 is extended to focal cortical dysplasias (FCDs) in familial focal epilepsies by extending the role of mTORC1 repressor toDEP domain‐containing protein 5.
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Evidence that Subanesthetic Doses of Ketamine Cause Sustained Disruptions of NMDA and AMPA-Mediated Frontoparietal Connectivity in Humans
Suresh D. Muthukumaraswamy,Alexander D Shaw,Laura E Jackson,Judith Hall,Rosalyn J. Moran,Neeraj Saxena +5 more
TL;DR: Subanesthetic doses of ketamine, similar to those used in antidepressant studies, increase anterior theta and gamma power but decrease posterior theta, delta, and alpha power, as revealed by magnetoencephalographic recordings.
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CB1 Receptor Signaling in the Brain: Extracting Specificity from Ubiquity
TL;DR: Findings on the current canonical view of the ‘ECS’ are summarized and findings that push for an expansion of ideas around long-held beliefs about eCB signaling are addressed, including how a nearly ubiquitous system can determine highly specific functions in the brain.
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Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer’s disease
Boaz Styr,Inna Slutsky +1 more
TL;DR: A hypothesis is suggested to explain the transition from ‘silent’ signatures of aberrant neural circuit activity to clinically evident memory impairments and failures in firing homeostasis and imbalance between stability and plasticity represent the driving force of early disease progression.
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A Synaptic Perspective of Fragile X Syndrome and Autism Spectrum Disorders.
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References
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mTOR Signaling in Growth Control and Disease
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.
Journal ArticleDOI
mTOR signaling in growth control and disease.
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
Journal ArticleDOI
The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses
TL;DR: This book aims to investigate elementary forms of learning and memory at a cellular molecular level—as specific molecular activities within identified nerve cells withinidentified nerve cells.
Journal ArticleDOI
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
TL;DR: Recent advances in understanding of the molecular structures and biochemical functions of the translation initiation machinery are described and key strategies that mediate general or gene-specific translational control are summarized, particularly in mammalian systems.
Journal ArticleDOI
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D. Sarbassov,Siraj M. Ali,Siraj M. Ali,Shomit Sengupta,Shomit Sengupta,Joon Ho Sheen,Joon Ho Sheen,Peggy P. Hsu,Peggy P. Hsu,Alex F. Bagley,Alex F. Bagley,Andrew L. Markhard,Andrew L. Markhard,David M. Sabatini,David M. Sabatini +14 more
TL;DR: It is shown that rapamycin inhibits the assembly of mTORC2 and that, in many cell types, prolongedRapamycin treatment reduces the levels of m TORC2 below those needed to maintain Akt/PKB signaling.
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