Journal ArticleDOI
mTOR complexes in neurodevelopmental and neuropsychiatric disorders
Reads0
Chats0
TLDR
The most recent advances in studies of mTOR signaling in the brain and the possible mechanisms underlying the many different functions of the mTOR complexes in neurological diseases are described and the medical relevance is discussed.Abstract:
The mechanistic target of rapamycin (mTOR) acts as a highly conserved signaling "hub" that integrates neuronal activity and a variety of synaptic inputs. mTOR is found in two functionally distinct complexes, mTORC1 and mTORC2, that crucially control long-term synaptic efficacy and memory storage. Dysregulation of mTOR signaling is associated with neurodevelopmental and neuropsychiatric disorders. In this Review, we describe the most recent advances in studies of mTOR signaling in the brain and the possible mechanisms underlying the many different functions of the mTOR complexes in neurological diseases. In addition, we discuss the medical relevance of these findings.read more
Citations
More filters
Posted ContentDOI
UBE3A–mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
Jiandong Sun,Yan Liu,Yousheng Jia,Jennifer Tran,Xiaoning Hao,Wei ju Lin,Gary Lynch,Michel Baudry,Xiaoning Bi +8 more
TL;DR: Ube3a regulates mTORC1 signaling by targeting p18, a subunit of the Ragulator, which is critical for typical synaptic plasticity and dendritic spine development.
Book ChapterDOI
Molecular mechanisms underlying cannabis-induced risk of psychosis
TL;DR: In this paper , the Akt/mTOR/S6 pathway was found to mediate the THC effects to turn the signaling of 5-HT2AR from the canonical non-hallucinogenic Gαq/11-proteins activation to the hallucinogenic gαi/o-protein-dependent response.
Posted ContentDOI
mTOR-RhoA signalling impairments in direct striatal projection neurons induce altered behaviours and striatal physiology in mice
Daniel Rial,Emma Puighermanal,Emmanuel Valjent,Serge N. Schiffmann,Alban de Kerchove d'Exaerde +4 more
TL;DR: Deep behavioural changes in absence of mTOR in dMSNs such as decreased spontaneous locomotion, impaired social interaction and repetitive behaviour are indicated, which identify mTOR RhoA signaling as an important regulator of striatal functions through an intricate mechanism involving RHoA and culminating in Kv1.1 overfunction, which could be targeted to treat striatal-related mTORopathies.
Journal ArticleDOI
Prenatal stress aggravates age-dependent cognitive decline, insulin signaling dysfunction, and the pro-inflammatory response in the APPNL-F/NL-F mouse model of Alzheimer's disease
Ewa Trojan,Katarzyna Curzytek,Paulina Cieślik,Joanna M. Wierońska,Johannes Graff,Władysław Lasoń,Takashi Saito,Takaomi C. Saido,Agnieszka Basta-Kaim +8 more
TL;DR: In this article , an increase in the Aβ42/Aβ40 ratio and mouse ApoE levels in the hippocampus and frontal cortex preceded the onset of cognitive deficits in the KI mice.
Journal ArticleDOI
Embryonic mercury exposure in zebrafish: Alteration of metabolites and gene expression, related to visual and behavioral impairments.
Noraini Abu Bakar,Wan Norhamidah Wan Ibrahim,Nur Atikah Saleh Hodin,Tae-Yoon Kim,Yee Soon Ling,Mohd Mokrish Md. Ajat,Khozirah Shaari,Shamarina Shohaimi,Nurrul Shaqinah Nasruddin,Siti Munirah Mohd Faudzi,Cheol-Hee Kim +10 more
TL;DR: In this paper , the authors showed that exposure of zebrafish larvae to 100 nM mercury chloride from gastrulation to hatching increased locomotor activity in the dark, reduced shoaling and exploratory behavior, and impaired color preference.
References
More filters
mTOR Signaling in Growth Control and Disease
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.
Journal ArticleDOI
mTOR signaling in growth control and disease.
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
Journal ArticleDOI
The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses
TL;DR: This book aims to investigate elementary forms of learning and memory at a cellular molecular level—as specific molecular activities within identified nerve cells withinidentified nerve cells.
Journal ArticleDOI
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
TL;DR: Recent advances in understanding of the molecular structures and biochemical functions of the translation initiation machinery are described and key strategies that mediate general or gene-specific translational control are summarized, particularly in mammalian systems.
Journal ArticleDOI
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D. Sarbassov,Siraj M. Ali,Siraj M. Ali,Shomit Sengupta,Shomit Sengupta,Joon Ho Sheen,Joon Ho Sheen,Peggy P. Hsu,Peggy P. Hsu,Alex F. Bagley,Alex F. Bagley,Andrew L. Markhard,Andrew L. Markhard,David M. Sabatini,David M. Sabatini +14 more
TL;DR: It is shown that rapamycin inhibits the assembly of mTORC2 and that, in many cell types, prolongedRapamycin treatment reduces the levels of m TORC2 below those needed to maintain Akt/PKB signaling.
Related Papers (5)
mTOR signaling: at the crossroads of plasticity, memory and disease.
Charles A. Hoeffer,Eric Klann +1 more