Journal ArticleDOI
mTOR complexes in neurodevelopmental and neuropsychiatric disorders
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TLDR
The most recent advances in studies of mTOR signaling in the brain and the possible mechanisms underlying the many different functions of the mTOR complexes in neurological diseases are described and the medical relevance is discussed.Abstract:
The mechanistic target of rapamycin (mTOR) acts as a highly conserved signaling "hub" that integrates neuronal activity and a variety of synaptic inputs. mTOR is found in two functionally distinct complexes, mTORC1 and mTORC2, that crucially control long-term synaptic efficacy and memory storage. Dysregulation of mTOR signaling is associated with neurodevelopmental and neuropsychiatric disorders. In this Review, we describe the most recent advances in studies of mTOR signaling in the brain and the possible mechanisms underlying the many different functions of the mTOR complexes in neurological diseases. In addition, we discuss the medical relevance of these findings.read more
Citations
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Journal ArticleDOI
Recapitulating developmental mechanisms for retinal regeneration
TL;DR: The current status and potential of the regenerative medicine approach for the retina in the backdrop of developmental mechanisms is examined.
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System-based proteomic and metabonomic analysis of the Df(16)A +/− mouse identifies potential miR-185 targets and molecular pathway alterations
Hendrik Wesseling,Bin Xu,Elizabeth J. Want,Elaine Holmes,Paul M. Guest,Maria Karayiorgou,Joseph A. Gogos,Sabine Bahn,Sabine Bahn +8 more
TL;DR: A schematic model is developed summarizing the most prominent molecular network findings in the Df(16)A+/− mouse, which can be linked to one of the most consistent and strongest proteomic candidates, OGT1, which is a predicted miR-185 target.
Journal ArticleDOI
Phytocannabinoids modulate emotional memory processing through interactions with the ventral hippocampus and mesolimbic dopamine system: implications for neuropsychiatric pathology.
TL;DR: Clinical and preclinical evidence demonstrating that distinct phytocannabinoids act within the VHipp and associated corticolimbic structures to modulate emotional memory processing through changes in mesolimbic DA activity states, salience attribution, and signal transduction pathways associated with schizophrenia-related pathology are summarized.
Book ChapterDOI
Mammalian Target of Rapamycin at the Crossroad Between Alzheimer's Disease and Diabetes.
TL;DR: This chapter discusses the role of mTOR signaling and the brain emphasis on its importance to overall organism health and longevity in Alzheimer's disease and type 2 diabetes mellitus.
Journal ArticleDOI
Effects of escitalopram and paroxetine on mTORC1 signaling in the rat hippocampus under chronic restraint stress
Mi Kyoung Seo,Cheol Min Choi,Roger S. McIntyre,Roger S. McIntyre,Hye Yeon Cho,Chan Hong Lee,Rodrigo B. Mansur,Rodrigo B. Mansur,Yena Lee,Jae-Hon Lee,Young Hoon Kim,Sung Woo Park,Jung Goo Lee +12 more
TL;DR: This study evaluated whether antidepressant drugs would exert differential effects on mTOR signaling in the rat hippocampus under conditions of chronic restraint stress to contribute to understanding the possible relationships among mTOR activity, stress, and antidepressant drugs.
References
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mTOR Signaling in Growth Control and Disease
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.
Journal ArticleDOI
mTOR signaling in growth control and disease.
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
Journal ArticleDOI
The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses
TL;DR: This book aims to investigate elementary forms of learning and memory at a cellular molecular level—as specific molecular activities within identified nerve cells withinidentified nerve cells.
Journal ArticleDOI
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
TL;DR: Recent advances in understanding of the molecular structures and biochemical functions of the translation initiation machinery are described and key strategies that mediate general or gene-specific translational control are summarized, particularly in mammalian systems.
Journal ArticleDOI
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D. Sarbassov,Siraj M. Ali,Siraj M. Ali,Shomit Sengupta,Shomit Sengupta,Joon Ho Sheen,Joon Ho Sheen,Peggy P. Hsu,Peggy P. Hsu,Alex F. Bagley,Alex F. Bagley,Andrew L. Markhard,Andrew L. Markhard,David M. Sabatini,David M. Sabatini +14 more
TL;DR: It is shown that rapamycin inhibits the assembly of mTORC2 and that, in many cell types, prolongedRapamycin treatment reduces the levels of m TORC2 below those needed to maintain Akt/PKB signaling.
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