Journal ArticleDOI
mTOR complexes in neurodevelopmental and neuropsychiatric disorders
TLDR
The most recent advances in studies of mTOR signaling in the brain and the possible mechanisms underlying the many different functions of the mTOR complexes in neurological diseases are described and the medical relevance is discussed.Abstract:
The mechanistic target of rapamycin (mTOR) acts as a highly conserved signaling "hub" that integrates neuronal activity and a variety of synaptic inputs. mTOR is found in two functionally distinct complexes, mTORC1 and mTORC2, that crucially control long-term synaptic efficacy and memory storage. Dysregulation of mTOR signaling is associated with neurodevelopmental and neuropsychiatric disorders. In this Review, we describe the most recent advances in studies of mTOR signaling in the brain and the possible mechanisms underlying the many different functions of the mTOR complexes in neurological diseases. In addition, we discuss the medical relevance of these findings.read more
Citations
More filters
Posted ContentDOI
Inhibition of mTOR during a postnatal sensitive window rescues deficits in GABAergic PV cell connectivity and social behavior caused by loss of TSC1.
Mayukh Choudhury,Clara Akofa Amegandjin,Vidya Jadhav,Josianne Nunes-Carrico,Ariane Quintal,Martin H. Berryer,Marina Snapyan,Bidisha Chattopadhyaya,Armen Saghatelyan,Graziella Di Cristo +9 more
TL;DR: A novel role of Tsc1-mTORC1 signaling is identified in the regulation of the developmental time course and maintenance of cortical PV cell connectivity and a mechanistic basis for the targeted rescue of autism-related behaviors in disorders associated with deregulated mTORC 1 signaling is provided.
Journal ArticleDOI
A multi‐organ analysis of the role of <scp>mTOR</scp> in fetal alcohol spectrum disorders
TL;DR: In this article , a review of recent advances in the field of fetal alcohol spectrum disorders (FASD) with regard to animal model discoveries and discuss the interaction between alcohol and mTOR in the context of various tissues, including brain, placenta, bone, and muscle, with respect to developmental alcohol exposure paradigms.
Journal ArticleDOI
Functional Genomic Analysis of Amphetamine Sensitivity in Drosophila
Caline S. Karam,Brenna L Williams,Irina Morozova,Qiaoping Yuan,R. Panarsky,Yuchao Zhang,Colin A. Hodgkinson,David Goldman,Sergey Kalachikov,Jonathan A. Javitch +9 more
TL;DR: In this paper , the authors used Drosophila as a model to examine AMPH-induced transcriptional changes that are DAT-dependent, as those would be the most relevant to the stimulatory effects of the drug.
Journal ArticleDOI
PFC mTOR signaling as a biological signature for cognitive deficits in bipolar disorder without psychosis
TL;DR: In this article, the PFC Akt-mTOR signaling in males with bipolar disorder (BD) without psychosis compared with those with psychosis, possibly related to cognitive deficits, was investigated.
Journal ArticleDOI
microRNA Biology on Brain Development and Neuroimaging Approach
TL;DR: A whole-brain imaging approach using MRI may be useful in revealing biological and pathological information about the brain affected by miRNAs, and recent advancements in the research of miRNA-mediated modulation of neuronal processes that are important for brain development and their involvement in disease pathogenesis are highlighted.
References
More filters
mTOR Signaling in Growth Control and Disease
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.
Journal ArticleDOI
mTOR signaling in growth control and disease.
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
Journal ArticleDOI
The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses
TL;DR: This book aims to investigate elementary forms of learning and memory at a cellular molecular level—as specific molecular activities within identified nerve cells withinidentified nerve cells.
Journal ArticleDOI
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
TL;DR: Recent advances in understanding of the molecular structures and biochemical functions of the translation initiation machinery are described and key strategies that mediate general or gene-specific translational control are summarized, particularly in mammalian systems.
Journal ArticleDOI
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D. Sarbassov,Siraj M. Ali,Siraj M. Ali,Shomit Sengupta,Shomit Sengupta,Joon Ho Sheen,Joon Ho Sheen,Peggy P. Hsu,Peggy P. Hsu,Alex F. Bagley,Alex F. Bagley,Andrew L. Markhard,Andrew L. Markhard,David M. Sabatini,David M. Sabatini +14 more
TL;DR: It is shown that rapamycin inhibits the assembly of mTORC2 and that, in many cell types, prolongedRapamycin treatment reduces the levels of m TORC2 below those needed to maintain Akt/PKB signaling.
Related Papers (5)
mTOR signaling: at the crossroads of plasticity, memory and disease.
Charles A. Hoeffer,Eric Klann +1 more