Murine Cerberus Homologue mCer-1: A Candidate Anterior Patterning Molecule
Christine Biben,Edouard G. Stanley,Louis Fabri,Surendra Kotecha,Rhinn M,C Drinkwater,M. Lah,Wang Cc,Andrew Nash,Douglas J. Hilton,Siew-Lan Ang,Timothy J. Mohun,Richard P. Harvey +12 more
TLDR
The data suggest that mCer-1 shares structural, functional, and expression characteristics with Xcer and may participate in patterning the anterior of the embryo and nascent somite region, in part, through a BMP-inhibitory mechanism.About:
This article is published in Developmental Biology.The article was published on 1998-02-15 and is currently open access. It has received 194 citations till now. The article focuses on the topics: Cerberus (protein) & Endoderm.read more
Citations
More filters
Journal ArticleDOI
Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells
Kevin A. D'Amour,Anne G. Bang,Susan Eliazer,Olivia Kelly,Alan D. Agulnick,Nora G Smart,Mark A. Moorman,Evert Kroon,Melissa K Carpenter,Emmanuel E. Baetge +9 more
TL;DR: A differentiation process that converts human embryonic stem cells to endocrine cells capable of synthesizing the pancreatic hormones insulin, glucagon, somatostatin, pancreatic polypeptide and ghrelin is developed.
Journal ArticleDOI
Efficient differentiation of human embryonic stem cells to definitive endoderm.
TL;DR: The process of definitive endoderm formation in differentiating hES cell cultures includes an apparent epithelial-to-mesenchymal transition and a dynamic gene expression profile that are reminiscent of vertebrate gastrulation that may facilitate the use of hES cells for therapeutic purposes and as in vitro models of development.
Journal ArticleDOI
Secreted antagonists of the Wnt signalling pathway
Yoshiaki Kawano,Robert M. Kypta +1 more
TL;DR: The extracellular antagonists of the Wnt signalling pathway can be divided into two broad classes: members of the sFRP (secreted Frizzled-related protein) family, WIF (Wnt inhibitory factor)-1 and Cerberus, primarily bind to Wnt proteins; the second class comprises certainMembers of the Dickkopf (Dkk) family; these families have as-yet-undiscovered functions.
Journal ArticleDOI
Bmp4 is required for the generation of primordial germ cells in the mouse embryo.
Kirstie A. Lawson,N. R. Dunn,Bernard A.J. Roelen,L. M. Zeinstra,A. M. Davis,Christopher V.E. Wright,J. P. W. F. M. Korving,Brigid L.M. Hogan +7 more
TL;DR: Ch Chimera analysis indicates that it is the Bmp4 expression in the extraembryonic ectoderm that regulates the formation of allantois and primordial germ cell precursors, and the size of the founding population of PGCs.
Journal ArticleDOI
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein
Mary E. Brunkow,Jessica Gardner,Jeff Van Ness,Bryan W. Paeper,Brian Kovacevich,Sean Proll,John E. Skonier,L. Zhao,P.J. Sabo,Ying-Hui Fu,Reid S. Alisch,Lucille Gillett,Trenton Colbert,Paolo Tacconi,David J. Galas,Herman Hamersma,Peter Beighton,John T. Mulligan +17 more
TL;DR: The specific and progressive effect on bone formation observed in individuals affected with sclerosteosis, along with the data presented in this study, together suggest that the SOST gene encodes an important new regulator of bone homeostasis.
References
More filters
Journal ArticleDOI
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
Yann Echelard,Douglas J. Epstein,Benoit St-Jacques,Liya Shen,Jym Mohler,Jill A. McMahon,Andrew P. McMahon +6 more
TL;DR: Three members of a mouse gene family related to the Drosophila segment polarity gene, hedgehog (hh), are identified and it is suggested that Shh may play a role in the normal inductive interactions that pattern the ventral CNS.
Journal ArticleDOI
pEF-BOS, a powerful mammalian expression vector.
TL;DR: The pEFBOS vector will be used to produce a large amount of growth factors and proteins in mammalian cells, to express a high level of anti-sense RNA, and will be an ideal positive control for CAT assay in various cell types.
Journal ArticleDOI
The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4
TL;DR: It is reported that noggin protein binds BMP4 with high affinity and can abolish B MP4 activity by blocking binding to cognate cell-surface receptors and these data suggest that nogsgin secreted by the organizer patterns the embryo by interrupting BMP signaling.
Journal ArticleDOI
Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos
TL;DR: The activity of exogenous noggin RNA in embryonic axis induction and the localized expression of endogenous noggan transcripts suggest that noggins plays a role in normal dorsal development.
Journal ArticleDOI
Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4
TL;DR: It is proposed that the noncell-autonomous effects of Spemann's organizer on dorsoventral patterning are executed in part by diffusible signals that directly bind to and neutralize ventral BMPs during gastrulation.