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Myocardial strain measurement with 2-dimensional speckle-tracking echocardiography: definition of normal range.

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TLDR
This multicenter study of nearly 250 volunteers without evidence of cardiovascular disease showed an average LV peak systolic strain of -18.6 +/- 0.1% and there was significant segmental variation of regional strain to necessitate the use of site-specific normal ranges.
Abstract
The interpretation of wall motion is an important component of echocardiography but remains a source of variation between observers. It has been believed that automated quantification of left ventricular (LV) systolic function by measurement of LV systolic strain from speckle-tracking echocardiography might be helpful. This multicenter study of nearly 250 volunteers without evidence of cardiovascular disease showed an average LV peak systolic strain of −18.6 ± 0.1%. Although strain was influenced by weight, blood pressure, and heart rate, these features accounted for only 16% of variance. However, there was significant segmental variation of regional strain to necessitate the use of site-specific normal ranges.

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Journal ArticleDOI

Age, Sex, and Blood Pressure-Related Influences on Reference Values of Left Atrial Deformation and Mechanics From a Large-Scale Asian Population.

TL;DR: Wang et al. as discussed by the authors studied 4042 participants undergoing annual cardiovascular survey and found that women demonstrated higher peak atrial longitudinal systolic strain (39.34±7.99% versus 37.95−7.96% for men.
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Incremental Prognostic Value of Echocardiographic Strain and Its Association With Mortality in Cancer Patients

TL;DR: Eastern Cooperative Oncology Group performance status, male sex, and GLS were significantly associated with all-cause mortality in patients with cancer with normal ejection fractions receiving chemotherapy.
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Evaluation of longitudinal and radial left ventricular function by two-dimensional speckle-tracking echocardiography in a large cohort of normal probands

TL;DR: The aim of this study was to characterize global and regional LV function by STE in a large cohort of healthy adult probands across a wide range of age to serve as reference for comparison with different disease entities.
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Right Ventricular Mechanics Using a Novel Comprehensive Three-View Echocardiographic Strain Analysis in a Normal Population

TL;DR: Eighteen-segment RV strain analysis is feasible, with strain measures falling into discrete ranges in this normal population, and important disease not seen in the four-chamber apical view alone is identified in the pilot population of 11 patients with RV disease.
Journal ArticleDOI

Diagnosis of Nonischemic Stage B Heart Failure in Type 2 Diabetes Mellitus: Optimal Parameters for Prediction of Heart Failure

TL;DR: Subclinical left ventricular systolic dysfunction is prevalent in asymptomatic elderly patients with type 2 diabetes mellitus, and impaired GLS is independent and incremental to LVH in the prediction of incident HF.
References
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Journal ArticleDOI

Two-dimensional strain-a novel software for real-time quantitative echocardiographic assessment of myocardial function.

TL;DR: In this paper, the authors assess the feasibility of 2D strain, a software for real-time quantitative echocardiographic assessment of myocardial function, which is based on the estimation that a discrete set of tissue velocities are present per each of many small elements on the ultrasound image.
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Quantitative assessment of intrinsic regional myocardial deformation by Doppler strain rate echocardiography in humans. Validation against three-dimensional tagged magnetic resonance imaging

TL;DR: The present study demonstrates the ability of Doppler echocardiography to measure myocardial strains in a clinical setting and may represent a new powerful method for quantifying left ventricular function noninvasively in humans.
Journal ArticleDOI

Can natural strain and strain rate quantify regional myocardial deformation? A study in healthy subjects

TL;DR: SR/epsilon imaging appears to be a robust technique for quantifying regional myocardial deformation, and values describing radial deformation were higher than the corresponding SR/ep silon values obtained for longitudinal deformation.
Journal ArticleDOI

Noninvasive quantification of regional myocardial function using Doppler-derived velocity, displacement, strain rate, and strain in healthy volunteers: effects of aging

TL;DR: Although myocardial velocities and strain rate showed significant dependence on age, displacement and peak systolic strain measures were less affected, and Doppler tissue echocardiography measurements showed a strong dependence on wall segment position.
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