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Myocardial strain measurement with 2-dimensional speckle-tracking echocardiography: definition of normal range.

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TLDR
This multicenter study of nearly 250 volunteers without evidence of cardiovascular disease showed an average LV peak systolic strain of -18.6 +/- 0.1% and there was significant segmental variation of regional strain to necessitate the use of site-specific normal ranges.
Abstract
The interpretation of wall motion is an important component of echocardiography but remains a source of variation between observers. It has been believed that automated quantification of left ventricular (LV) systolic function by measurement of LV systolic strain from speckle-tracking echocardiography might be helpful. This multicenter study of nearly 250 volunteers without evidence of cardiovascular disease showed an average LV peak systolic strain of −18.6 ± 0.1%. Although strain was influenced by weight, blood pressure, and heart rate, these features accounted for only 16% of variance. However, there was significant segmental variation of regional strain to necessitate the use of site-specific normal ranges.

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Journal ArticleDOI

Phenotypic and pathophysiological heterogeneity in heart failure with preserved ejection fraction

TL;DR: This editorial refers to ‘Discriminating clinical features of heart failure with preserved vs. reduced ejection fraction in the community’ as well as traditional non-invasive parameters of diastolic function have performed poorly in discriminating HFpEF patients from their co-morbidity-matched symptom-free patients.
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Normal reference values of left ventricular strain using three-dimensional speckle tracking echocardiography: results from a multicentre study

TL;DR: Normal ranges of global and regional LV strain using 3DSTE have been established for clinical use, and there are differences between different segments, walls, and levels as part of the functional non-uniformity of the normal LV that necessitates the use of segment-specific normal ranges for radial and longitudinal strains.
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Biventricular mechanics in constrictive pericarditis comparison with restrictive cardiomyopathy and impact of pericardiectomy.

TL;DR: In this article, the authors compared myocardial mechanics of constrictive pericarditis (CP) with restrictive cardiomyopathy (RCM), or healthy controls, and quantitated the effect of pericardiectomy.
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Patterns of left ventricular longitudinal strain and strain rate in Olympic athletes.

TL;DR: The present study shows that highly trained athletes have normal GLS and strain rate parameters of the left ventricle, despite mild differences compared with untrained controls, and these data may be implemented as reference values for the clinical assessment of the athletes and to support the diagnosis of physiologic cardiac adaptations in borderline cases.
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Two-dimensional speckle tracking imaging detects impaired myocardial performance in children with septic shock, not recognized by conventional echocardiography.

TL;DR: Speckle tracking imaging detected a number of significantly impaired measures of ventricular performance in children with sepsis, not appreciated by conventional echocardiography, which may improve the understanding and identification of myocardial depression in the critically ill septic child.
References
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Journal ArticleDOI

Two-dimensional strain-a novel software for real-time quantitative echocardiographic assessment of myocardial function.

TL;DR: In this paper, the authors assess the feasibility of 2D strain, a software for real-time quantitative echocardiographic assessment of myocardial function, which is based on the estimation that a discrete set of tissue velocities are present per each of many small elements on the ultrasound image.
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Quantitative assessment of intrinsic regional myocardial deformation by Doppler strain rate echocardiography in humans. Validation against three-dimensional tagged magnetic resonance imaging

TL;DR: The present study demonstrates the ability of Doppler echocardiography to measure myocardial strains in a clinical setting and may represent a new powerful method for quantifying left ventricular function noninvasively in humans.
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Can natural strain and strain rate quantify regional myocardial deformation? A study in healthy subjects

TL;DR: SR/epsilon imaging appears to be a robust technique for quantifying regional myocardial deformation, and values describing radial deformation were higher than the corresponding SR/ep silon values obtained for longitudinal deformation.
Journal ArticleDOI

Noninvasive quantification of regional myocardial function using Doppler-derived velocity, displacement, strain rate, and strain in healthy volunteers: effects of aging

TL;DR: Although myocardial velocities and strain rate showed significant dependence on age, displacement and peak systolic strain measures were less affected, and Doppler tissue echocardiography measurements showed a strong dependence on wall segment position.
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