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Myocardial strain measurement with 2-dimensional speckle-tracking echocardiography: definition of normal range.

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TLDR
This multicenter study of nearly 250 volunteers without evidence of cardiovascular disease showed an average LV peak systolic strain of -18.6 +/- 0.1% and there was significant segmental variation of regional strain to necessitate the use of site-specific normal ranges.
Abstract
The interpretation of wall motion is an important component of echocardiography but remains a source of variation between observers. It has been believed that automated quantification of left ventricular (LV) systolic function by measurement of LV systolic strain from speckle-tracking echocardiography might be helpful. This multicenter study of nearly 250 volunteers without evidence of cardiovascular disease showed an average LV peak systolic strain of −18.6 ± 0.1%. Although strain was influenced by weight, blood pressure, and heart rate, these features accounted for only 16% of variance. However, there was significant segmental variation of regional strain to necessitate the use of site-specific normal ranges.

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References
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Journal ArticleDOI

Two-dimensional strain-a novel software for real-time quantitative echocardiographic assessment of myocardial function.

TL;DR: In this paper, the authors assess the feasibility of 2D strain, a software for real-time quantitative echocardiographic assessment of myocardial function, which is based on the estimation that a discrete set of tissue velocities are present per each of many small elements on the ultrasound image.
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Quantitative assessment of intrinsic regional myocardial deformation by Doppler strain rate echocardiography in humans. Validation against three-dimensional tagged magnetic resonance imaging

TL;DR: The present study demonstrates the ability of Doppler echocardiography to measure myocardial strains in a clinical setting and may represent a new powerful method for quantifying left ventricular function noninvasively in humans.
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Can natural strain and strain rate quantify regional myocardial deformation? A study in healthy subjects

TL;DR: SR/epsilon imaging appears to be a robust technique for quantifying regional myocardial deformation, and values describing radial deformation were higher than the corresponding SR/ep silon values obtained for longitudinal deformation.
Journal ArticleDOI

Noninvasive quantification of regional myocardial function using Doppler-derived velocity, displacement, strain rate, and strain in healthy volunteers: effects of aging

TL;DR: Although myocardial velocities and strain rate showed significant dependence on age, displacement and peak systolic strain measures were less affected, and Doppler tissue echocardiography measurements showed a strong dependence on wall segment position.
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