Journal ArticleDOI
Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration
TLDR
This work focuses on the best-studied subclasses, the neural cell adhesion molecule NCAM and the L1 family of adhesion molecules, which share important structural and functional features and are instructive for elucidating the mechanisms by which other recognition molecules may guide cell interactions during development or modify their function as a result of injury, learning and memory.Abstract:
Recognition molecules of the immunoglobulin superfamily have important roles in neuronal interactions during ontogeny, including migration, survival, axon guidance and synaptic targeting. Their downstream signal transduction events specify whether a cell changes its place of residence or projects axons and dendrites to targets in the brain, allowing the construction of a dynamic neural network. A wealth of recent discoveries shows that cell adhesion molecules interact with attractant and repellent guidance receptors to control growth cone and cell motility in a coordinate fashion. We focus on the best-studied subclasses, the neural cell adhesion molecule NCAM and the L1 family of adhesion molecules, which share important structural and functional features. We have chosen these paradigmatic molecules and their interactions with other recognition molecules as instructive for elucidating the mechanisms by which other recognition molecules may guide cell interactions during development or modify their function as a result of injury, learning and memory.read more
Citations
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Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
TL;DR: The cell-matrix and cell-cell adhesion, protease, and cytokine systems that underlie tissue invasion by cancer cells are described and explained to explain how the reciprocal reprogramming of both the tumor cells and the surrounding tissue structures not only guides invasion, but also generates diverse modes of dissemination.
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The trip of the tip: understanding the growth cone machinery
TL;DR: The understanding of the functions and regulation of the vehicle and navigator provides new insights into the cell biology of growth cone guidance.
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Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis
Manuel Valiente,Anna C. Obenauf,Xin Jin,Qing Chen,Xiang Zhang,Derek J. Lee,Jamie E. Chaft,Mark G. Kris,Jason T. Huse,Edi Brogi,Joan Massagué +10 more
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Metastatic stem cells: sources, niches, and vital pathways.
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Polysialic acid in the plasticity of the developing and adult vertebrate nervous system.
TL;DR: The ability of PSA to increase the plasticity of neural cells is being exploited to improve the repair of adult CNS tissue.
References
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Journal ArticleDOI
Cell migration: integrating signals from front to back.
Anne J. Ridley,Martin A. Schwartz,Keith Burridge,Richard A. Firtel,Mark H. Ginsberg,Gary G. Borisy,J. Thomas Parsons,Alan Rick Horwitz +7 more
TL;DR: The mechanisms underlying the major steps of migration and the signaling pathways that regulate them are described, and recent advances investigating the nature of polarity in migrating cells and the pathways that establish it are outlined.
Journal ArticleDOI
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
W. James Nelson,Roel Nusse +1 more
TL;DR: Evidence is assembled of possible interrelations between Wnt and other growth factor signaling, β-catenin functions, and cadherin-mediated adhesion in tissue differentiation.
Journal ArticleDOI
Spectrin and Ankyrin-Based Pathways: Metazoan Inventions for Integrating Cells Into Tissues
Vann Bennett,Anthony J. Baines +1 more
TL;DR: This review deals with the molecular physiology of spectrin, ankyrin, which links spectrin to the anion exchanger, and two spectrin-associated proteins that promote spectrin interactions with actin: adducin and protein 4.1.
Journal ArticleDOI
The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands.
TL;DR: The results uncover an unexpected intersection between short- and long-range mechanisms of intercellular communication and reveal a pathway for GDNF signaling that does not require the RET receptor.
Journal ArticleDOI
Glycans and neural cell interactions
Ralf Kleene,Melitta Schachner +1 more
TL;DR: Carbohydrate-carrying molecules in the nervous system have important roles during development, regeneration and synaptic plasticity and the tremendous structural diversity of glycan chains allows for immense combinatorial possibilities that might underlie the fine-tuning of cell–cell and cell–matrix interactions.