Journal ArticleDOI
Neuroendocrinology of reproduction in teleost fish.
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TLDR
Although precise information as to the physiological effects of KiSS1 in fish, notably on GnRH neurons and gonadotropin release, is still limited, KiSS neurons may emerge as the "gatekeeper" of puberty and reproduction in fish as in mammals.About:
This article is published in General and Comparative Endocrinology.The article was published on 2010-02-01. It has received 732 citations till now. The article focuses on the topics: Neuroendocrinology & Gonadotropin.read more
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Kisspeptin Signaling in the Brain
TL;DR: Kisspeptin signaling in the brain has been implicated in mediating the negative feedback action of sex steroids on gonadotropin secretion, generating the preovulatory GnRH/LH surge, triggering and guiding the tempo of sexual maturation at puberty, controlling seasonal reproduction, and restraining reproductive activity during lactation.
Journal ArticleDOI
Effects of climate change on fish reproduction and early life history stages
TL;DR: A companion effect of marine climate change is ocean acidification, which may pose a significant threat through its capacity to alter larval behaviour and impair sensory capabilities, which in turn impacts on population replenishment and connectivity patterns of marine fishes.
Journal ArticleDOI
Physiological impacts of elevated carbon dioxide and ocean acidification on fish
Rachael M. Heuer,Martin Grosell +1 more
TL;DR: The present review presents a clear message that ocean acidification may cause significant effects on fish across multiple physiological systems, suggesting that pH compensation does not necessarily confer tolerance as downstream consequences and tradeoffs occur.
Journal ArticleDOI
Use of Zebrafish in Drug Discovery Toxicology
Steven Cassar,Isaac Adatto,Jennifer L. Freeman,Joshua T. Gamse,Iñaki Iturria,Christian Lawrence,Arantza Muriana,Randall T. Peterson,Steven Van Cruchten,Leonard I. Zon +9 more
TL;DR: The zebrafish model is a bridge between in vitro assays and mammalian in vivo studies, which is powerful in its breadth of application and tractability for research, and the 3Rs value that it can deliver is discussed.
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Organization of Two Independent Kisspeptin Systems Derived from Evolutionary-Ancient Kiss Genes in the Brain of Zebrafish
Arianna Servili,Yann Le Page,Jérôme Leprince,Alain Caraty,Sebastián Escobar,Ishwar S. Parhar,Jae Yong Seong,Hubert Vaudry,Olivier Kah +8 more
TL;DR: The data indicate that the kiss2 systems of zebrafish are implicated in reproductive events, while the kiss1 gene would play other functions that remain to be established.
References
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Journal ArticleDOI
Multiple receptors for dopamine.
John W. Kebabian,Donald B. Calne +1 more
TL;DR: Pharmacological and biochemical criteria can be used to separate those dopamine receptors which are linked to the enzyme adenylyl cyclase and those which are not.
Journal ArticleDOI
The GPR54 gene as a regulator of puberty
Stephanie B. Seminara,Sophie Messager,Emmanouella E. Chatzidaki,Rosemary R. Thresher,James S. Acierno,Jenna K. Shagoury,Yousef Bo-Abbas,Wendy Kuohung,Kristine M. Schwinof,Alan G. Hendrick,Dirk Zahn,John Dixon,Ursula B. Kaiser,Susan A. Slaugenhaupt,James F. Gusella,Stephen O'Rahilly,Mark Carlton,William F. Crowley,Samuel Aparicio,William H. Colledge +19 more
TL;DR: Puberty is initiated when gonadotropin-releasing hormone begins to be secreted by the hypothalamus, and complementary genetic approaches in humans and mice identified genetic factors that determine the onset of puberty.
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Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
Nicolas de Roux,Emmanuelle Génin,Jean Claude Carel,Fumihiko Matsuda,Chaussain Jl,Edwin Milgrom +5 more
TL;DR: The present study shows that loss of function of GPR54 is a cause of IHH, and it identifies GPR 54 and possibly KiSS1 protein-derived peptide as playing a major and previously unsuspected role in the physiology of the gonadotropic axis.
Journal ArticleDOI
The probability of duplicate gene preservation by subfunctionalization.
Michael Lynch,Allan Force +1 more
TL;DR: The model proposed herein leads to quantitative predictions that are consistent with observations on the frequency of long-term duplicate gene preservation and with observations that indicate that a common fate of the members of duplicate-gene pairs is the partitioning of tissue-specific patterns of expression of the ancestral gene.
Journal ArticleDOI
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
Masato Kotani,Michel Detheux,Ann Vandenbogaerde,David Communi,Jean-Marie Vanderwinden,Emmanuel Le Poul,Stéphane Brézillon,Richard Tyldesley,Nathalie Suarez-Huerta,Fabrice Vandeput,Cédric Blanpain,Serge N. Schiffmann,Gilbert Vassart,Marc Parmentier +13 more
TL;DR: Stimulation of oxytocin secretion after kisspeptin administration to rats confirmed this hypothesis that human GPR54 was highly expressed in placenta, pituitary, pancreas, and spinal cord, suggesting a role in the regulation of endocrine function.