Journal ArticleDOI
Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation.
Marco Peviani,Eleonora Salvaneschi,Leonardo Bontempi,Alessandro Petese,Antonio Manzo,Daniela Rossi,Mario Salmona,Simona Collina,Paolo Bigini,Daniela Curti +9 more
TLDR
The results support pharmacological manipulation of S1R as a promising strategy to cure ALS and point to increased availability of growth factors and modulation of astrocytosis and of macrophage/microglia as part of the mechanisms involved in S 1R-mediated neuroprotection.About:
This article is published in Neurobiology of Disease.The article was published on 2014-02-01. It has received 107 citations till now. The article focuses on the topics: Motor neuron & Neurodegeneration.read more
Citations
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Compromised MAPK signaling in human diseases: an update
Eunkyung Kim,Eui Ju Choi +1 more
TL;DR: Recent research on the roles of MAPK signaling pathways in human diseases, with a focus on cancer and neurodegenerative conditions is summarized.
Journal ArticleDOI
Amyotrophic Lateral Sclerosis: A Focus on Disease Progression
Ana C. Calvo,Raquel Manzano,Deise M. F. Mendonça,María Jesús Muñoz,Pilar Zaragoza,Rosario Osta +5 more
TL;DR: The progression of the disease is discussed from the viewpoint of the potential biomarkers described to date in human and animal model samples and potential therapeutic strategies for ALS treatment and future, innovative perspectives are considered.
Journal ArticleDOI
The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems
TL;DR: This work proposes that Sig-1R is a pluripotent modulator with resultant multiple functional manifestations in living systems and investigates its role in central nervous system diseases.
Journal ArticleDOI
Role of sigma-1 receptors in neurodegenerative diseases.
Linda Nguyen,Brandon Lucke-Wold,Shona A. Mookerjee,John Z. Cavendish,Matthew J. Robson,Anna L. Scandinaro,Rae R. Matsumoto +6 more
TL;DR: An overview of the biological mechanisms frequently associated with neurodegeneration is provided, and how sigma-1 receptors may alter these mechanisms to preserve or restore neuronal function is discussed.
Journal ArticleDOI
Mitochondria‐associated membrane collapse is a common pathomechanism in SIGMAR1‐ and SOD1‐linked ALS
Seiji Watanabe,Hristelina Ilieva,Hristelina Ilieva,Hiromi Tamada,Hanae Nomura,Okiru Komine,Fumito Endo,Shijie Jin,Pedro Mancias,Hiroshi Kiyama,Koji Yamanaka +10 more
TL;DR: The findings indicate that a loss of Sig1R function is causative for ALS16, and collapse of the MAM is a common pathomechanism in both Sig 1R‐ and SOD1‐linked ALS, and the discovery of the selective enrichment of IP3R3 in motor neurons suggests that integrity of theMAM is crucial for the selective vulnerability in ALS.
References
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Journal ArticleDOI
Fiji: an open-source platform for biological-image analysis
Johannes Schindelin,Ignacio Arganda-Carreras,Erwin Frise,Verena Kaynig,Mark Longair,Tobias Pietzsch,Stephan Preibisch,Curtis Rueden,Stephan Saalfeld,Benjamin Schmid,Jean-Yves Tinevez,Daniel J. White,Volker Hartenstein,Kevin W. Eliceiri,Pavel Tomancak,Albert Cardona +15 more
TL;DR: Fiji is a distribution of the popular open-source software ImageJ focused on biological-image analysis that facilitates the transformation of new algorithms into ImageJ plugins that can be shared with end users through an integrated update system.
Journal ArticleDOI
Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord.
Kristina A. Kigerl,John C. Gensel,Daniel P. Ankeny,Jessica K. Alexander,Dustin J. Donnelly,Phillip G. Popovich +5 more
TL;DR: Together, these data suggest that polarizing the differentiation of resident microglia and infiltrating blood monocytes toward an M2 or “alternatively” activated macrophage phenotype could promote CNS repair while limiting secondary inflammatory-mediated injury.
Journal ArticleDOI
Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival
Teruo Hayashi,Tsung-Ping Su +1 more
TL;DR: The results reveal that the orchestrated ER chaperone machinery at MAM, by sensing ER Ca(2+) concentrations, regulates ER-mitochondrial interorganellar Ca( 2+) signaling and cell survival.
Journal ArticleDOI
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
Makiko Nagai,Diane B. Re,Tetsuya Nagata,Alcmène Chalazonitis,Thomas M. Jessell,Hynek Wichterle,Serge Przedborski +6 more
TL;DR: It is shown that expression of mutated human SOD1 in primary mouse spinal motor neurons does not provoke motor neuron degeneration, and indicates that astrocytes may play a role in the specific degeneration of spinal motor neuron neurons in ALS.
Journal ArticleDOI
Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
TL;DR: The evidence is reviewed here the evidence that it is the convergence of damage developed within multiple cell types, including within neighboring nonneuronal supporting cells, which is crucial to neuronal dysfunction.
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Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival
Teruo Hayashi,Tsung-Ping Su +1 more