NMDA receptor-dependent switching between different gamma rhythm-generating microcircuits in entorhinal cortex
Steven J. Middleton,Jozsi Jalics,Tilman J. Kispersky,Fiona E. N. LeBeau,Anita K. Roopun,Nancy Kopell,Miles A. Whittington,Mark O. Cunningham +7 more
TLDR
The two different gamma frequencies matched the different intrinsic frequencies in hippocampal areas CA3 and CA1, suggesting that NMDA receptor activation may control the nature of temporal interactions between mEC and hippocampus, thus influencing the pathway for information transfer between the two regions.Abstract:
Local circuits in the medial entorhinal cortex (mEC) and hippocampus generate gamma frequency population rhythms independently. Temporal interaction between these areas at gamma frequencies is implicated in memory—a phenomenon linked to activity of NMDA-subtype glutamate receptors. While blockade of NMDA receptors does not affect frequency of gamma rhythms in hippocampus, it exposes a second, lower frequency (25–35 Hz) gamma rhythm in mEC. In experiment and model, NMDA receptor-dependent mEC gamma rhythms were mediated by basket interneurons, but NMDA receptor-independent gamma rhythms were mediated by a novel interneuron subtype—the goblet cell. This cell was distinct from basket cells in morphology, intrinsic membrane properties and synaptic inputs. The two different gamma frequencies matched the different intrinsic frequencies in hippocampal areas CA3 and CA1, suggesting that NMDA receptor activation may control the nature of temporal interactions between mEC and hippocampus, thus influencing the pathway for information transfer between the two regions.read more
Citations
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Spatiotemporal characteristics and pharmacological modulation of multiple gamma oscillations in the CA1 region of the hippocampus.
TL;DR: It is indicated that multiple distinct local circuits generate γ-oscillations in the CA1 region of the hippocampus, and detailed information about their spatiotemporal characteristics is provided.
Journal ArticleDOI
μ-Opioid receptor activation modulates CA3-to-CA1 gamma oscillation phase-coupling.
Yujiao Zhang,Sanya Ahmed,Georgiana Neagu,Yali Wang,Zhenyi Li,Jianbin Wen,Chunjie Liu,Martin Vreugdenhil,Martin Vreugdenhil,Martin Vreugdenhil +9 more
TL;DR: CA3 gamma oscillation drives CA1 gamma and suppresses CA1 intrinsic fast γ and μ-opioid receptor (MOR) activation reduces γ frequency in CA3 and CA1, which results in Uncoupling of CA1 γ from CA3 γ.
Journal ArticleDOI
NMDA receptor antagonists distort visual grouping in rats performing a modified two-choice visual discrimination task.
Katja Clarissa Ward,Halima Zainab Khattak,Louise Richardson,Jonathan L.C. Lee,Martin Vreugdenhil +4 more
TL;DR: The Glass pattern-based visual grouping task is able to differentiate the effect of psychotomimetic NMDA receptor antagonists on visual perception from the effects on motor and memory functions, which allows quantification of cognitive psychosis in rodents and allows half-maximum performance signal level to be translated to human psychometric functions.
Journal ArticleDOI
Mitochondria and cortical gamma oscillations: food for thought?
TL;DR: Increasingly, modalities such as functional MRI and positron emission tomography are finding their place in clinical neurological practice and provide useful information concerning both physiological and pathophysiological modes of operation in particular regions of the brain.
Journal ArticleDOI
Suppression of Low-Frequency Gamma Oscillations by Activation of 40-Hz Oscillation.
Shunsuke Sugiyama,Tomoya Taniguchi,Tomoaki Kinukawa,Nobuyuki Takeuchi,Kazutaka Ohi,Toshiki Shioiri,Makoto Nishihara,Koji Inui +7 more
TL;DR: In this article, a magnetoencephalographic study of brain oscillations in a wide frequency range was examined using a time-frequency analysis during the 20-, 30-, 40-, and 50-Hz auditory stimuli in 21 healthy subjects.
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