Nonlinear Sorting, Curvature Generation, and Crowding of Endophilin N-BAR on Tubular Membranes
Chen Zhu,S. Das,Tobias Baumgart +2 more
TLDR
The spontaneous curvature induced by endophilin is determined and a nonlinear curvature/composition coupling model is developed that predicts a curvature-induced phase transition among two states with varying protein density and membrane curvature.About:
This article is published in Biophysical Journal.The article was published on 2012-04-18 and is currently open access. It has received 117 citations till now. The article focuses on the topics: Membrane curvature & Membrane tubulation.read more
Citations
More filters
Journal ArticleDOI
Curvature, lipid packing, and electrostatics of membrane organelles: defining cellular territories in determining specificity.
Joëlle Bigay,Bruno Antonny +1 more
TL;DR: Whereas some rare lipids contribute to the identity of cell organelles, this work focuses on the abundant lipids that form the matrix of organelle membranes, which provide specificity for reactions occurring along the secretory pathway, on the plasma membrane, and also on lipid droplets and autophagosomes.
Journal ArticleDOI
When Physics Takes Over: BAR Proteins and Membrane Curvature
Mijo Simunovic,Gregory A. Voth,Andrew Callan-Jones,Patricia Bassereau,Patricia Bassereau,Patricia Bassereau +5 more
TL;DR: In this paper, the authors summarize the multifaceted coupling of Bin/amphiphysin/Rvs (BAR) proteins to membrane mechanics and propose a simple phase diagram that recapitulates the effects of these parameters.
Journal ArticleDOI
IRSp53 senses negative membrane curvature and phase separates along membrane tubules
Coline Prévost,Hongxia Zhao,John Manzi,John Manzi,John Manzi,Emmanuel Lemichez,Pekka Lappalainen,Andrew Callan-Jones,Patricia Bassereau,Patricia Bassereau,Patricia Bassereau +10 more
TL;DR: An original assay in which proteins are encapsulated in giant unilamellar vesicles connected to membrane nanotubes is developed, demonstrating that I-BAR dimers sense negative membrane curvature and allows constriction of weakly curved membranes coupled to local protein enrichment at biologically relevant conditions.
Journal ArticleDOI
Protein sorting by lipid phase-like domains supports emergent signaling function in B lymphocyte plasma membranes.
TL;DR: It is shown that lipid mediated forces can bias biochemical networks in ways that broadly impact signal transduction and are demonstrated to be generalized to other signaling pathways.
Journal ArticleDOI
Membrane tension and peripheral protein density mediate membrane shape transitions
Zheng Shi,Tobias Baumgart +1 more
TL;DR: Experimental evidence is provided for a mechanism whereby membrane tension reduction initiates membrane budding and tubulation mediated by endocytic proteins such as endophilin A1, and a membrane shape stability diagram is obtained that shows remarkable consistency with a quantitative model.
References
More filters
Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Data Reduction and Error Analysis for the Physical Sciences
TL;DR: In this paper, Monte Carlo techniques are used to fit dependent and independent variables least squares fit to a polynomial least-squares fit to an arbitrary function fitting composite peaks direct application of the maximum likelihood.
Journal ArticleDOI
Data Reduction and Error Analysis for the Physical Sciences.
TL;DR: Numerical methods matrices graphs and tables histograms and graphs computer routines in Pascal and Monte Carlo techniques dependent and independent variables least-squares fit to a polynomial least-square fit to an arbitrary function fitting composite peaks direct application of the maximum likelihood.
Journal ArticleDOI
Membrane curvature and mechanisms of dynamic cell membrane remodelling
TL;DR: Membrane curvature is no longer seen as a passive consequence of cellular activity but an active means to create membrane domains and to organize centres for membrane trafficking.
Journal ArticleDOI
BAR domains as sensors of membrane curvature: the amphiphysin BAR structure
Brian J. Peter,Helen M. Kent,Ian G. Mills,T. Yvonne Vallis,P. Jonathan G. Butler,Philip R. Evans,Harvey T. McMahon +6 more
TL;DR: The structure of the Drosophila amphiphysin BAR domain is solved and it is predicted that BAR domains are in many protein families, including sorting nexins, centaurins, and oligophrenins.