Novel Platforms for the Development of a Universal Influenza Vaccine.
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TLDR
The development of a novel or improved universal influenza vaccines may be greatly facilitated by new technologies including virus-like particles, T-cell-inducing peptides and recombinant proteins, synthetic viruses, broadly neutralizing antibodies, and nucleic acid-based vaccines.Abstract:
Despite advancements in immunotherapeutic approaches, influenza continues to cause severe illness, particularly among immunocompromised individuals, young children, and elderly adults. Vaccination is the most effective way to reduce rates of morbidity and mortality caused by influenza viruses. Frequent genetic shift and drift among influenza-virus strains with the resultant disparity between circulating and vaccine virus strains limits the effectiveness of the available conventional influenza vaccines. One approach to overcome this limitation is to develop a universal influenza vaccine that could provide protection against all subtypes of influenza viruses. Moreover, the development of a novel or improved universal influenza vaccines may be greatly facilitated by new technologies including virus-like particles, T-cell-inducing peptides and recombinant proteins, synthetic viruses, broadly neutralizing antibodies, and nucleic acid-based vaccines. This review discusses recent scientific advances in the development of next-generation universal influenza vaccines.read more
Citations
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COVID-19 vaccine: A recent update in pipeline vaccines, their design and development strategies.
TL;DR: The immunopathological basis of vaccine designing that can be approached for vaccine development against SARS-CoV-2 infection and different platforms that are being used for vaccineDeveloping is discussed and the current status of vaccine development and associated outcomes reported at different phases of trial is given.
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Trained Immunity-Based Vaccines: A New Paradigm for the Development of Broad-Spectrum Anti-infectious Formulations.
Silvia Sánchez-Ramón,Laura Conejero,Mihai G. Netea,David Sancho,Oscar Palomares,José Luis Subiza +5 more
TL;DR: The TIbV concept may be used for the development of vaccines focused to promote host resistance against a wide spectrum of pathogens, and may apply to increase immunogenicity of novel vaccine design approaches based on small molecules, like those achieved by reverse vaccinology.
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Immunoinformatics and Vaccine Development: An Overview.
Angus Nnamdi Oli,Wilson Okechukwu Obialor,M. Ifeanyichukwu,Damian Chukwu Odimegwu,Jude Nnaemeka Okoyeh,George Ogonna Emechebe,Samson A. Adejumo,Gordon C. Ibeanu +7 more
TL;DR: Insight is given into the need to focus on novel computational, experimental and computation-driven experimental approaches for studying of host–pathogen interactions and thus making a case for its use in vaccine development.
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Injectable Hydrogels for Sustained Codelivery of Subunit Vaccines Enhance Humoral Immunity.
Gillie A. Roth,Emily C. Gale,Marcela Alcántara-Hernández,Wei Luo,Eneko Axpe,Rohit Verma,Qian Yin,Anthony C. Yu,Hector Lopez Hernandez,Caitlin L. Maikawa,Anton A. A. Smith,Mark M. Davis,Bali Pulendran,Juliana Idoyaga,Eric A. Appel +14 more
TL;DR: This work utilized an injectable and self-healing polymer–nanoparticle (PNP) hydrogel platform to prolong the codelivery of vaccine components to the immune system, and introduced a simple and effective vaccine delivery platform that increases the potency and durability of subunit vaccines.
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