Journal ArticleDOI
Opioid-induced hyperalgesia: Cellular and molecular mechanisms.
TLDR
The molecular actors identified include the Toll-like receptor 4 and the anti-opioid systems as well as some other excitatory molecules, receptors, channels, chemokines, pro-inflammatory cytokines or lipids, which contribute to OIH.About:
This article is published in Neuroscience.The article was published on 2016-12-03. It has received 269 citations till now.read more
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Journal ArticleDOI
Prevention and Treatment of Opioid Misuse and Addiction: A Review.
TL;DR: The factors that triggered the opioids crisis and its further evolution are analyzed, along with the interventions to manage and prevent opioid use disorder (OUD), which are fundamental for curtailing the opioid crisis.
Journal ArticleDOI
Perioperative opioid analgesia—when is enough too much? A review of opioid-induced tolerance and hyperalgesia
TL;DR: Clinical and mechanism-based understanding of tolerance and opioid-induced hyperalgesia are focused on, current and future strategies for pain management are discussed, and alternatives include inhibition of peripheral μ opioid receptors and blockade of downstream signalling mechanisms.
Journal ArticleDOI
Persistent Postsurgical Pain: Pathophysiology and Preventative Pharmacologic Considerations.
TL;DR: Clinical investigations evaluating different preventative pharmacologic strategies that are routinely used by anesthesiologists in their daily clinical practices for preventing persistent postoperative pain are described.
Journal ArticleDOI
Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia.
Gregory Corder,Vivianne L. Tawfik,Dong Wang,Elizabeth I. Sypek,Sarah A. Low,Jasmine R. Dickinson,Chaudy Sotoudeh,J. David Clark,Ben A. Barres,Christopher J. Bohlen,Grégory Scherrer +10 more
TL;DR: The data support the idea that opioid agonists can be combined with peripheral MOR antagonists to limit analgesic tolerance and OIH in perioperative and chronic pain models.
Journal ArticleDOI
Endogenous and Exogenous Opioids in Pain.
TL;DR: This review describes the functional organization and pharmacology of the endogenous opioid system and discusses the loci of opioid analgesic action along peripheral and central pain pathways, emphasizing the pain-relieving properties of opioids against the affective dimension of the pain experience.
References
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Journal ArticleDOI
Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment.
TL;DR: In this article, a large-scale computer-assisted telephone survey was conducted to explore the prevalence, severity, treatment and impact of chronic pain in 15 European countries and Israel and found that chronic pain is a major health care problem in Europe that needs to be taken more seriously.
Journal ArticleDOI
Upstream and downstream of mTOR
Nissim Hay,Nahum Sonenberg +1 more
TL;DR: Both the upstream components of the signaling pathway(s) that activates mammalian TOR (mTOR) and the downstream targets that affect protein synthesis are described.
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Cellular and Molecular Mechanisms of Pain
TL;DR: Genetic, electrophysiological, and pharmacological studies are elucidating the molecular mechanisms that underlie detection, coding, and modulation of noxious stimuli that generate pain.
Journal ArticleDOI
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
Michael J. Caterina,A. Leffler,Annika B. Malmberg,William J. Martin,Jodie A. Trafton,K. R. Petersen-Zeitz,Martin Koltzenburg,Allan I. Basbaum,David Julius +8 more
TL;DR: Sensory neurons from mice lacking VR1 are severely deficient in their responses to each of these noxious stimuli and are impaired in the detection of painful heat, and showed little thermal hypersensitivity in the setting of inflammation.
Journal ArticleDOI
Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor
Christopher N. Parkhurst,Guang Yang,Ipe Ninan,Jeffrey N. Savas,John R. Yates,Juan J. Lafaille,Barbara L. Hempstead,Dan R. Littman,Wen-Biao Gan +8 more
TL;DR: It is found that microglia could be specifically depleted from the brain upon diphtheria toxin administration and removal of brain-derived neurotrophic factor (BDNF) frommicroglia largely recapitulated the effects of microglian depletion.