Paracetamol, aspirin, and indomethacin induce endocrine disturbances in the human fetal testis capable of interfering with testicular descent.
Séverine Mazaud-Guittot,Christophe Nicolas Nicolaz,Christèle Desdoits-Lethimonier,Isabelle Coiffec,Millissia Ben Maamar,Patrick Balaguer,David Møbjerg Kristensen,David Møbjerg Kristensen,Cécile Chevrier,Vincent Lavoué,Patrice Poulain,Nathalie Dejucq-Rainsford,Bernard Jégou,Bernard Jégou +13 more
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TLDR
It is suggested that the fetal human testis displays slight critical age windows for sensitivity to direct exposure to aspirin, indomethacin, and paracetamol, and analgesics at concentrations relevant to human exposure cause endocrine disturbances in the fetal testis.Abstract:
Context: Masculinization depends on the fetal testis. Exposure of the human fetus during pregnancy to paracetamol and/or to other mild analgesics is associated with an increased risk of cryptorchidism. Objective: We aimed to determine whether mild analgesics disrupted the morphology and endocrine function of the human testis. Design: We used an in vitro system based on the culture of human fetal testes exposed or not to paracetamol, its metabolite N-(4-hydroxyphenyl)-arachidonoylethanolamide (AM404), aspirin, indomethacin, and ketoconazole at 10−4 to 10−7 M. Setting: The study was conducted at the University of Rennes I. Patients/Participants: Human fetal testes were from pregnant women after induced abortion, between 7 and 12 weeks of gestation (GW). Main Outcome Measures: Testosterone (RIA), anti-Mullerian hormone (ELISA), insulin-like factor 3 (RIA), and prostaglandin (PG) D2 and PGE2 (ELISA) were assayed in the medium. Testicular cells were counted using histology and image analysis. The possible nucl...read more
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Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility
Niels E. Skakkebæk,Ewa Rajpert-De Meyts,Germaine M. Buck Louis,Jorma Toppari,Anna-Maria Andersson,Michael L. Eisenberg,Tina Kold Jensen,Niels Jørgensen,Shanna H. Swan,Katherine J. Sapra,Søren Ziebe,Lærke Priskorn,Anders Juul +12 more
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Biodegradable polymers and their nano-composites for the removal of endocrine-disrupting chemicals (EDCs) from wastewater: A review.
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Prenatal Exposure to Acetaminophen and Risk of ADHD
Eivind Ystrom,Kristin Gustavson,Ragnhild Eek Brandlistuen,Gun Peggy Knudsen,Per Magnus,Per Magnus,Ezra Susser,Ezra Susser,George Davey Smith,Camilla Stoltenberg,Camilla Stoltenberg,Pål Surén,Siri E. Håberg,Mady Hornig,W. Ian Lipkin,Hedvig Nordeng,Ted Reichborn-Kjennerud,Ted Reichborn-Kjennerud +17 more
TL;DR: Long-term maternal use of acetaminophen during pregnancy was substantially associated with ADHD even after adjusting for indications of use, familial risk of ADHD, and other potential confounders.
References
More filters
Journal ArticleDOI
Male development of chromosomally female mice transgenic for Sry
TL;DR: It is shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.
Journal ArticleDOI
Decrease in anogenital distance among male infants with prenatal phthalate exposure
Shanna H. Swan,Katharina M. Main,Fan Liu,Sara Stewart,Robin L. Kruse,Antonia M. Calafat,Catherine S. Mao,J. Bruce Redmon,Christine L. Ternand,S.J. Sullivan,J.Lynn Teague +10 more
TL;DR: The hypothesis that prenatal phthalate exposure at environmental levels can adversely affect male reproductive development in humans is supported.
Journal ArticleDOI
Male reproductive health and environmental xenoestrogens
Jorma Toppari,John Chr. Larsen,Peter Christiansen,Aleksander Giwercman,Philippe Grandjean,Louis J. Guillette,Bernard Jégou,Tina Kold Jensen,Pierre Jouannet,Niels Keiding,Henrik Leffers,John A. McLachlan,Otto A. Meyer,Jørn Müller,E. Rajpert-De Meyts,Thomas H. Scheike,Richard M. Sharpe,John P. Sumpter,Niels E. Skakkebæk +18 more
TL;DR: The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estrogenic or other hormonally active environmental chemicals during fetal and childhood development.
Journal ArticleDOI
Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs
TL;DR: It is shown that indomethacin binds and activates peroxisome proliferator-activated receptor γ (PPARγ), a ligand-activated transcription factor known to play a pivotal role in adipogenesis, and several other NSAIDs are also PPARγ ligands and induce adipocyte differentiation of C3H10T1/2 cells.
Journal ArticleDOI
Cryptorchidism in mice mutant for Insl3.
Serge Nef,Luis F. Parada +1 more
TL;DR: It is shown that mice mutant for Insl3 are viable, but exhibit bilateral cryptorchidism due to developmental abnormalities of the gubernaculum, resulting in abnormal spermatogenesis and infertility, and roles for InSl3 in the development of the urogenital tract and in female fertility are revealed.