Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy.
TLDR
This review summarizes the potential of triterpenes belonging to the lupane, oleanane or ursane group, to treat cancer by different modes of action and utilisation of different plants as their sources is of interest.Abstract:
Today cancer treatment is not only a question of eliminating cancer cells by induction of cell death. New therapeutic strategies also include targeting the tumour microenvironment, avoiding angiogenesis, modulating the immune response or the chronic inflammation that is often associated with cancer. Furthermore, the induction of redifferentiation of dedifferentiated cancer cells is an interesting aspect in developing new therapy strategies. Plants provide a broad spectrum of potential drug substances for cancer therapy with multifaceted effects and targets. Pentacyclic triterpenes are one group of promising secondary plant metabolites. This review summarizes the potential of triterpenes belonging to the lupane, oleanane or ursane group, to treat cancer by different modes of action. Since Pisha et al. reported in 1995 that betulinic acid is a highly promising anticancer drug after inducing apoptosis in melanoma cell lines in vitro and in vivo, experimental work focused on the apoptosis inducing mechanisms of betulinic acid and other triterpenes. The antitumour effects were subsequently confirmed in a series of cancer cell lines from other origins, for example breast, colon, lung and neuroblastoma. In addition, in the last decade many studies have shown further effects that justify the expectation that triterpenes are useful to treat cancer by several modes of action. Thus, triterpene acids are known mainly for their antiangiogenic effects as well as their differentiation inducing effects. In particular, lupane-type triterpenes, such as betulin, betulinic acid and lupeol, display anti-inflammatory activities which often accompany immune modulation. Triterpene acids as well as triterpene monoalcohols and diols also show an antioxidative potential. The pharmacological potential of triterpenes of the lupane, oleanane or ursane type for cancer treatment seems high; although up to now no clinical trial has been published using these triterpenes in cancer therapy. They provide a multitarget potential for coping with new cancer strategies. Whether this is an effective approach for cancer treatment has to be proven. Because various triterpenes are an increasingly promising group of plant metabolites, the utilisation of different plants as their sources is of interest. Parts of plants, for example birch bark, rosemary leaves, apple peel and mistletoe shoots are rich in triterpenes and provide different triterpene compositions.read more
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Oleanolic acid inhibits cell proliferation migration and invasion and induces SW579 thyroid cancer cell line apoptosis by targeting forkhead transcription factor A.
TL;DR: Investigation of the biological functions of OA found that OA may be a potential chemotherapeutic agent against thyroid carcinoma cells and high FOXA1 expression predicted the poor prognosis of patients with thyroid cancer.
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Ex vivo Skin Permeation of Betulin from Water-in-Oil Foams.
Anna Färber,Rolf Daniels +1 more
TL;DR: All formulation types can be used alike for the treatment of wounds, and the results that have already been obtained with oleogels can be directly translated to the foam with its superior use properties.
Journal ArticleDOI
Antiangiogenic activity of PLGA-Lupeol implants for potential intravitreal applications.
Daniel Crístian Ferreira Soares,Diogo Coelho de Paula Oliveira,Lucíola S. Barcelos,Alan Sales Barbosa,Lorena Carla Vieira,Danyelle M. Townsend,Domenico Rubello,André Luís Branco de Barros,Lucienir Pains Duarte,Armando Silva-Cunha +9 more
TL;DR: Overall, the results suggest lupeol-loaded PLGA ocular implants were able to inhibit the angiogenic process by impairing both proliferation and migration of endothelial cells.
Journal ArticleDOI
Impact of Mistletoe Triterpene Acids on the Uptake of Mistletoe Lectin by Cultured Tumor Cells
Katharina Mulsow,Thomas Enzlein,Catharina I. Delebinski,Sebastian Jaeger,Georg Seifert,Matthias F. Melzig +5 more
TL;DR: The intracellular uptake of the mistletoe lectin I (ML) by cultured tumor cells was investigated and revealed that the uptake in THP-1, HL-60- and Ewing TC-71-cells was independent of the addition of TT extract, and Interestingly, the uptake of ML by 143B-cells could only be measured after addition of triterpenes pointing to resistance to mistle toe lectin.
Journal ArticleDOI
Synthesis, transformation and biological evaluation of 2,3-secotriterpene acetylhydrazones and their derivatives
Victoria V. Grishko,I. A. Tolmacheva,Natalia V. Galaiko,Anastasia V. Pereslavceva,Lada V. Anikina,Larisa V. Volkova,Boris A. Bachmetyev,Pavel A. Slepukhin +7 more
TL;DR: Investigation in the anti-proliferative activity of the heterocyclic derivatives has shown high sensitivity of A-549, MS and RD tumor cell lines to lupane (R)-oxadiazoline 11a, and the pro-apoptotic effect of 11a was confirmed by the AnnexinV/PI analysis.
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