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Journal ArticleDOI

Peritoneal mesothelioma: PSOGI/EURACAN clinical practice guidelines for diagnosis, treatment and follow-up.

Psogi
- 01 Jan 2021 - 
- Vol. 47, Iss: 1, pp 36-59
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TLDR
In this paper, a steering committee for standardizing diagnosis and management of peritoneal mesothelioma (PM) is established, which is a rare and aggressive malignancy characterized by widespread multiple metastatic tumour nodules originating from the peritoneum.
Abstract
Peritoneal mesothelioma (PM) is a rare and aggressive primary peritoneal malignancy characterized by widespread multiple metastatic tumour nodules originating from the peritoneum. The conventional classification distinguishes diffuse malignant peritoneal mesothelioma (DMPM) and border-line forms: multicystic peritoneal mesothelioma (MCPM) and well-differentiated papillary peritoneal mesothelioma (WDPPM). Despite the novel achievements in the management of PM, there is difficulty in conducting randomized trials due to its rarity and aggressive biology in many cases. As there is, a necessity to standardize diagnosis and management of PM, the Peritoneal Surface Oncology Group International (PSOGI) commissioned a steering committee to elaborate clinical guidelines.

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Journal ArticleDOI

Advances in the management of peritoneal malignancies

TL;DR: Improvements in knowledge of the biology, assessment and classification, perioperative and surgical management, systemic treatment and pre-emptive management of peritoneal surface malignancies are comprehensively described.
Journal ArticleDOI

Laparoscopic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for limited peritoneal metastasis. The PSOGI international collaborative registry.

TL;DR: Analysis of individual patient data demonstrates that L-CRS+HIPEC is a safe and feasible procedure in highly selected patients with limited peritoneal disease when performed at experienced centres, while short to midterm outcomes are encouraging in patients with less invasive histology.
References
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Phase III Study of Pemetrexed in Combination With Cisplatin Versus Cisplatin Alone in Patients With Malignant Pleural Mesothelioma

TL;DR: Treatment with pemetrexed plus cisplatin and vitamin supplementation resulted in superior survival time, time to progression, and response rates compared with treatment with cis Platin alone in patients with malignant pleural mesothelioma.
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Introduction to The 2015 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus, and Heart.

TL;DR: The 2015 WHO Classification of Tumors of the Lung, Pleura, Thymus and Heart features the incorporation of many exciting new advances in thoracic tumor diagnosis and classification.
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Binding of Ovarian Cancer Antigen CA125/MUC16 to Mesothelin Mediates Cell Adhesion

TL;DR: The data indicate that mesothelin is a novel CA125-binding protein and that CA125 might contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to Mesothelin.
Journal ArticleDOI

Results of the Two Incidence Screenings in the National Lung Screening Trial

TL;DR: Low-dose CT was more sensitive in detecting early-stage lung cancers, but its measured positive predictive value was lower than that of radiography, and the two annual incidence screenings with low- dose CT resulted in a decrease in the number of advanced-stage cancers diagnosed and an increase in thenumber of early-Stage lung cancers diagnosed.
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