Peroxisome biogenesis, membrane contact sites, and quality control
TLDR
The current status of the different co‐existing modes of biogenesis of peroxisomal membrane proteins demonstrating the fascinating adaptability in their targeting and sorting pathways is reviewed.Abstract:
Peroxisomes are conserved organelles of eukaryotic cells with important roles in cellular metabolism, human health, redox homeostasis, as well as intracellular metabolite transfer and signaling. We review here the current status of the different co-existing modes of biogenesis of peroxisomal membrane proteins demonstrating the fascinating adaptability in their targeting and sorting pathways. While earlier studies focused on peroxisomes as autonomous organelles, the necessity of the ER and potentially even mitochondria as sources of peroxisomal membrane proteins and lipids has come to light in recent years. Additionally, the intimate physical juxtaposition of peroxisomes with other organelles has transitioned from being viewed as random encounters to a growing appreciation of the expanding roles of such inter-organellar membrane contact sites in metabolic and regulatory functions. Peroxisomal quality control mechanisms have also come of age with a variety of mechanisms operating both during biogenesis and in the cellular response to environmental cues.read more
Citations
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Axonal Endoplasmic Reticulum Dynamics and Its Roles in Neurodegeneration.
TL;DR: The transport processes that must contribute to this dynamic behavior of endoplasmic reticulum are discussed, and the model that these processes underpin a homeostatic process that ensures both enough ER to maintain continuity of the network and repair breaks in it is discussed.
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Transforming yeast peroxisomes into microfactories for the efficient production of high-value isoprenoids
TL;DR: Yeast peroxisomal engineering is transformed into microfactories for geranyl diphosphate-derived compounds, focusing on monoterpenoids, monoterpene indole alkaloids, and cannabinoids, and establish synthesis of 8-hydroxygeraniol, the precursor of monoterPene indoles alkaloid, and cannabigerolic acid, the cannabinoid precursor.
Journal ArticleDOI
Pexophagy: A Model for Selective Autophagy
Kyla Germain,Peter K. Kim +1 more
TL;DR: Pexophagy, the autophagic degradation of peroxisomes, is highlighted as a model for selective autophagy to infer how the cell may coordinate the degradation of individual substrates by selective autophile across different cellular cues.
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Versatility of Preprotein Transfer from the Cytosol to Mitochondria.
TL;DR: How a network of cytosolic machineries and targeting pathways promote and regulate preprotein transfer into mitochondria is discussed, which suggests an unexpected versatility of protein transfer to mitochondria.
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Peroxisome Metabolism in Cancer
TL;DR: The potential of inactivating peroxisomes to target cancer metabolism, which may pave the way for more effective cancer treatment is discussed.
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