Physiological Dynamics in Demyelinating Diseases: Unraveling Complex Relationships through Computer Modeling
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TLDR
This work will discuss how computational modeling applied to questions at different biological levels can help link together disparate observations and decipher complex mechanisms whose solutions are not amenable to simple reductionism.Abstract:
Despite intense research, few treatments are available for most neurological disorders. Demyelinating diseases are no exception. This is perhaps not surprising considering the multifactorial nature of these diseases, which involve complex interactions between immune system cells, glia and neurons. In the case of multiple sclerosis, for example, there is no unanimity among researchers about the cause or even which system or cell type could be ground zero. This situation precludes the development and strategic application of mechanism-based therapies. We will discuss how computational modeling applied to questions at different biological levels can help link together disparate observations and decipher complex mechanisms whose solutions are not amenable to simple reductionism. By making testable predictions and revealing critical gaps in existing knowledge, such models can help direct research and will provide a rigorous framework in which to integrate new data as they are collected. Nowadays, there is no shortage of data; the challenge is to make sense of it all. In that respect, computational modeling is an invaluable tool that could, ultimately, transform how we understand, diagnose, and treat demyelinating diseases.read more
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References
More filters
Journal ArticleDOI
Membrane properties in chronic inflammatory demyelinating polyneuropathy.
TL;DR: Threshold tracking was used to compare excitability properties of the median nerve in patients with chronic inflammatory demyelinating polyneuropathy and healthy controls, and there were no consistent changes in threshold electrotonus, suggesting that, for the studied axons, there are no consistentChanges in accommodation properties that depend on internodal conductances.
Journal ArticleDOI
Mitochondrial dysfunction and neurodegeneration in multiple sclerosis.
TL;DR: A focused review highlights recent evidence supporting the hypothesis that pathological permeability transition pore (PTP) opening mediated by reactive oxygen species (ROS) and calcium dysregulation is central to mitochondrial dysfunction and neurodegeneration in MS.
Journal ArticleDOI
Studies on the Natural History of Multiple Sclerosis: V. Long-Term Survival in Young Men
John F. Kurtzke,Gilbert W. Beebe,Benedict Nagler,M. Dean Nefzger,Thomas L. Auth,Leonard T. Kurland +5 more
TL;DR: The US veteran population is an exceptional resource for the study of disease, which comprises an enumerable population, well-indexed at many points of medical interest, and with a potential for long-term follow-up study that is unparalleled in the United States.
Journal ArticleDOI
From the Background to the Spotlight: TASK Channels in Pathological Conditions
TL;DR: It could be demonstrated that TASK1−/− mice are protected from experimental autoimmune inflammation while the same animals display increased infarct volumes after cerebral ischemia, indicating that TasK channels are per se neither protective nor detrimental but their functional impact depends on the “pathophysiological” scenario.
Journal ArticleDOI
Paroxysmal attacks in multiple sclerosis.
TL;DR: It is demonstrated that paroxysmal attacks occur early in the course of the disease, when there is little or no neurologic disability and associated tissue damage.