Journal ArticleDOI
Phytosterols, phytostanols, and their conjugates in foods: structural diversity, quantitative analysis, and health-promoting uses
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TLDR
Phytosterols and phytostanols have received much attention in the last five years because of their cholesterol-lowering properties and the popularity of these products has caused the medical and biochemical community to focus much attention on phytosterol research activity.About:
This article is published in Progress in Lipid Research.The article was published on 2002-11-01. It has received 1014 citations till now. The article focuses on the topics: Phytosterol & Sterol.read more
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Journal ArticleDOI
Is Plant Sterols a Good Strategy to Lower Cholesterol
TL;DR: The efficacy of dietary PS in managing cholesterol levels based on findings from recent studies is discussed and evidence on supporting the efficacy, the metabolic claims, inter-individual variations as well as sitosterolemia associated with PS intake is reviewed.
Book ChapterDOI
Methods for Extractions of Value-Added Nutraceuticals From Lignocellulosic Wastes and Their Health Application
TL;DR: In this article, the authors combine mathematical and statistical techniques for analyzing problems, with several independent variables having a control on a dependent variable, to create a suitable optimized model of physicobiological parameters, such as response surface methodology (Box Benkhen Design, Central Composite Design) and artificial neural network (ANN), have been preferred because of their proven advantages.
Journal ArticleDOI
Photoaffinity Labeling and Mutational Analysis of 24-C-Sterol Methyltransferase Defines the AdoMet Binding Site
Pruthvi Jayasimha,W. David Nes +1 more
TL;DR: Photolabeling and site-directed mutagenesis were performed on recombinant Saccharomyces cerevisiae 24-C-sterol methyltransferase (SMT) to elucidate the location and role of active site residues involved in AdoMet binding and catalysis.
Studies on a Cholesterol-Lowering Microcrystalline Phytosterol suspension in Oil
TL;DR: In this article, a cholesterol-lowering micro-crystalline phytosterol suspension in oil was used to reduce serum cholesterol levels in the small intestine of mice using a dynamic in vitro study.
Journal ArticleDOI
A novel poly (NMA-co-DEA-co-EDMA) monolithic column as a sorbent for online solid-phase extraction and its application in the determination of β-sitosterol in plant oil samples.
Huimin Wang,Huimin Wang,Haiyan Liu,Haiyan Liu,Bin Guo,Bin Guo,Dandan Lan,Dandan Lan,Xiaomin Pang,Xiaomin Pang,Hongyuan Yan,Hongyuan Yan,Dandan Han,Huaizhong Guo,Huaizhong Guo,Ligai Bai,Ligai Bai +16 more
TL;DR: The results showed that the monolith could be used as an online SPE absorbent for the determination of β-sitosterol in plant oil samples.
References
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Journal ArticleDOI
A rapid method of total lipid extraction and purification.
E. G. Bligh,W. J. Dyer +1 more
TL;DR: The lipid decomposition studies in frozen fish have led to the development of a simple and rapid method for the extraction and purification of lipids from biological materials that has been applied to fish muscle and may easily be adapted to use with other tissues.
Journal ArticleDOI
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Scott M. Grundy,David W. Bilheimer,Alan Chait,Luther T. Clark,Margo A. Denke,Richard J. Havel,William R. Hazzard,Stephen B. Hulley,Donald B. Hunninghake,Robert A. Kreisberg,Penny M. Kris-Etherton,James M. McKenney,Michael A. Newman,Ernst J. Schaefer,Burton E. Sobel,Carolyn Somelofski,Milton C. Weinstein,H. Bryan Brewer,James I. Cleeman,Karen A. Donato,Nancy D. Ernst,Jeffrey M. Hoeg,Basil M. Rifkind,Jacques E. Rossouw,Christopher T. Sempos,Joanne M. Gallivan,Maureen N. Harris,Laurie Quint-Adler +27 more
TL;DR: Dairy therapy remains the first line of treatment of high blood cholesterol, and drug therapy is reserved for patients who are considered to be at high risk for CHD, and the fundamental approach to treatment is comparable.
Book
Comprehensive insect physiology, biochemistry, and pharmacology
G. A. Kerkut,L. I. Gilbert +1 more
Journal ArticleDOI
Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters
Knut Erik Berge,Hui Tian,Gregory A. Graf,Liqing Yu,Nick V. Grishin,Joshua Schultz,Peter Kwiterovich,Bei Shan,Robert Barnes,Helen H. Hobbs +9 more
TL;DR: Data suggest that ABCG5 and ABCG8 normally cooperate to limit intestinal absorption and to promote biliary excretion of sterols, and that mutated forms of these transporters predispose to sterol accumulation and atherosclerosis.