Journal ArticleDOI
PLGA-dendron nanoparticles enhance immunogenicity but not lethal antibody production of a DNA vaccine against anthrax in mice
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TLDR
Results indicate that the PLGA-C(18) dendriplex particles produced superior levels of anti-PA IgG antibodies in comparison to animals immunized with thePLGA- C(0) dendedriplex particle, and it is likely that the mice lack protection against lethal toxin and anthrax infection.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2007-03-01. It has received 48 citations till now. The article focuses on the topics: Bacillus anthracis.read more
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Nonviral Vectors for Gene Delivery
TL;DR: Two nonviral gene delivery systems using either biodegradable poly(D,Llactide-co-glycolide) (PLG) nanoparticles or cell penetrating peptide (CPP) complexes have been designed and studied using A549 human lung epithelial cells.
Journal ArticleDOI
Current advances in research and clinical applications of PLGA-based nanotechnology
Jian-Ming Lü,Xinwen Wang,Christian Marin-Muller,Hao Wang,Peter H. Lin,Qizhi Yao,Changyi Chen +6 more
TL;DR: More recent successes of applying PLGA-based nanotechnologies and tools in medicine-related applications are presented and the possible mechanisms, diagnosis and treatment effects of PLGA preparations and devices are focused on.
Journal ArticleDOI
Cationic polymers and their therapeutic potential
Sangram Keshari Samal,Mamoni Dash,Sandra Van Vlierberghe,David L. Kaplan,Emo Chiellini,Clemens van Blitterswijk,Lorenzo Moroni,Peter Dubruel +7 more
TL;DR: The most recent scientific advances in cationic polymers and their derivatives not only for gene delivery purposes but also for various alternative therapeutic applications are reviewed.
Journal ArticleDOI
Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives
TL;DR: This critical review focuses on the design of biocompatible dendrimer-based nanoplatforms for targeted cancer diagnosis and therapy and theBiocompatibility aspects of d endrimers such as nanotoxicity, long-term circulation, and degradation are discussed.
Journal ArticleDOI
A Single-Dose PLGA Encapsulated Protective Antigen Domain 4 Nanoformulation Protects Mice against Bacillus anthracis Spore Challenge
TL;DR: The possibility of the development of a single-dose and adjuvant-free protective antigen based anthrax vaccine in the form of PAD4-NP is demonstrated for the first time.
References
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Journal ArticleDOI
Immunotherapeutic uses of CpG oligodeoxynucleotides
TL;DR: Ongoing clinical studies indicate that CpG ODN use is safe in humans, and that they modulate the immune response to co-administered allergens and vaccines.
Journal ArticleDOI
Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens
TL;DR: This review examines several impediments to PLGA microparticle development, such as PLGA-encapsulated antigen instability and deficiency of animal models in predicting human response, and describes new trends in overcoming these important issues.
Journal ArticleDOI
Bacterial DNA Induces Murine Interferon-γ Production by Stimulation of Interleukin-12 and Tumor Necrosis Factor-α
Melissa D. Halpern,Melissa D. Halpern,Roger Kurlander,Roger Kurlander,David S. Pisetsky,David S. Pisetsky +5 more
TL;DR: Results indicate that the stimulation of IFN-γ production by bacterial DNA is mediated by IL-12 and TNF-α and point to macrophages/monocytes as targets of action of this macromolecule.
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Poly(lactide-co-glycolide) microparticles for the development of single-dose controlled-release vaccines.
TL;DR: The adjuvant effect of PLG microparticles are discussed, and their potential for the development of single-dose vaccines through the use of controlled-release technology is discussed.
Journal ArticleDOI
Efficacy of a human anthrax vaccine in guinea pigs, rabbits, and rhesus macaques against challenge by Bacillus anthracis isolates of diverse geographical origin
P.F. Fellows,M.K. Linscott,Bruce E. Ivins,Margaret L. Pitt,Cynthia A. Rossi,Paul H. Gibbs,Arthur M. Friedlander +6 more
TL;DR: It is demonstrated that, although AVA confers variable protection against different B. anthracis isolates in guinea pigs, it is highly protective against these same isolate in both rabbits and rhesus macaques.
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Biodegradable nanoparticles for drug and gene delivery to cells and tissue
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