Journal ArticleDOI
Polymer microfluidic devices
Holger Becker,Laurie E. Locascio +1 more
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TLDR
This article presents a review of polymer-based microfluidic systems including their material properties, fabrication methods, device applications, and finally an analysis of the market that drives their development.About:
This article is published in Talanta.The article was published on 2002-02-11. It has received 1150 citations till now.read more
Citations
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Journal ArticleDOI
Microfluidics for cell-based assays
TL;DR: The behavior of confined fluids differs from macroscopic systems and allows precise control of the chemical composition of fluids, as well as the temporal and spatial patterns of microscopic fluid elements as discussed by the authors.
Journal ArticleDOI
Microfluidic device to study arterial shear-mediated platelet-surface interactions in whole blood: reduced sample volumes and well-characterised protein surfaces.
Nigel Kent,Nigel Kent,Lourdes Basabe-Desmonts,Gerardene Meade,Brian D. MacCraith,Brian Corcoran,Dermot Kenny,Antonio J. Ricco +7 more
TL;DR: A novel device to analyze cell-surface interactions under controlled fluid-shear conditions on well-characterised protein surfaces that can track the dose response of anti-platelet drugs, is suitable for point-of-care diagnostics, and is designed for adaptation to mass manufacture is reported.
Journal ArticleDOI
Fabrication of calcium fluoride capillary electrophoresis microdevices for on-chip infrared detection.
TL;DR: These CaF2 microdevices open the door to microchip separations with optical detection in the ultraviolet, visible, and infrared spectral regions.
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Fluidic interconnections for microfluidic systems: A new integrated fluidic interconnection allowing plug‘n’play functionality
TL;DR: A new reversible, integrated fluidic interconnection composed of custom-made cylindrical rings integrated in a polymer house next to the fluidic network is proposed, which allows plug‘n’play functionality between external metal ferrules and the system.
Journal ArticleDOI
Injection molded chips with integrated conducting polymer electrodes for electroporation of cells
Kristian Andresen,Morten Hartvig Hansen,Maria Matschuk,Søren Terpager Jepsen,Henrik Schiøtt Sørensen,P. Utko,D. Selmeczi,Thomas Steen Hansen,Niels Bent Larsen,Noemi Rozlosnik,Rafael J. Taboryski +10 more
TL;DR: The use of AC voltage for electroporation is demonstrated by applying a 1 kHz, ±50 V square pulse train to the electrodes and delivery of polynucleotide fluorescent dye is shown in 46% of human acute monocytic leukemia cells passing the constriction.
References
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Book
CRC Handbook of Chemistry and Physics
TL;DR: CRC handbook of chemistry and physics, CRC Handbook of Chemistry and Physics, CRC handbook as discussed by the authors, CRC Handbook for Chemistry and Physiology, CRC Handbook for Physics,
Journal ArticleDOI
Rapid prototyping of microfluidic systems in poly(dimethylsiloxane)
TL;DR: A procedure that makes it possible to design and fabricate microfluidic systems in an elastomeric material poly(dimethylsiloxane) (PDMS) in less than 24 h by fabricating a miniaturized capillary electrophoresis system is described.
Journal ArticleDOI
Fabrication of microfluidic systems in poly(dimethylsiloxane)
J.C. McDonald,David C. Duffy,Janelle R. Anderson,Daniel T. Chiu,Hongkai Wu,Olivier Schueller,George M. Whitesides +6 more
TL;DR: Fabrication of microfluidic devices in poly(dimethylsiloxane) (PDMS) by soft lithography provides faster, less expensive routes to devices that handle aqueous solutions.
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A Sequencing Method Based on Real-Time Pyrophosphate
Journal ArticleDOI
Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip
TL;DR: In this article, the authors demonstrated a miniaturized system for sample handling and separation using electrophoresis-based separations of amino acids with up to 75,000 theoretical plates in about 15 seconds.