Journal ArticleDOI
Polymorphic variation at the serotonin 1-A receptor gene is associated with comorbid depression and generalized anxiety
Esther Molina,Jorge A. Cervilla,Margarita Rivera,Francisco Torres,Juan Ángel Bellón,Berta Moreno,Michael King,Irwin Nazareth,Blanca Gutiérrez +8 more
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TLDR
The HTR1A C(-1019)G polymorphism was found to be associated to the frequent clinical presentation of comorbid MD and GAD, suggesting a common genetic background for mixed depression and anxiety states.Abstract:
BackgroundSerotonin 1-A receptors are key regulators of serotonin activity and their dysregulation might be implicated in the emergence of both major depression (MD) and generalized anxiety disorder (GAD). Previous studies have yielded inconclusive results as to whether the 5-HT1A receptor gene (HTRread more
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Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression
TL;DR: A model of serotonin-PFC circuitry that integrates evidence from mouse genetic models of anxiety and depression involving knockout, suppression, over-expression, or mutation of genes of the serotonin system including 5-HT1A receptors is presented.
Journal ArticleDOI
5-HT(1A) [corrected] receptors in mood and anxiety: recent insights into autoreceptor versus heteroreceptor function.
TL;DR: There is strong and growing evidence for a functional dissociation between auto- and heteroreceptor populations in mediating anxiety and depressive-like behaviors, respectively.
Journal ArticleDOI
Biological markers for anxiety disorders, OCD and PTSD - a consensus statement. Part I: Neuroimaging and genetics.
Borwin Bandelow,David S. Baldwin,Marianna Abelli,Carlo Altamura,Bernardo Dell'Osso,Katharina Domschke,Naomi A. Fineberg,Edna Grünblatt,Marek Jarema,Eduard Maron,David J. Nutt,Stefano Pini,Matilde M. Vaghi,Adam Wichniak,Gwyneth Zai,Peter Riederer +15 more
TL;DR: Although at present, none of the putative biomarkers is sufficient and specific as a diagnostic tool, an abundance of high-quality research has accumulated that will improve the understanding of the neurobiological causes of anxiety disorders, OCD and PTSD.
Journal ArticleDOI
Genetics of generalized anxiety disorder and related traits.
TL;DR: This review serves as a systematic guide to the genetics of generalized anxiety disorder (GAD) and further focuses on anxiety-relevant endophenotypes, such as pathological worry fear of uncertainty, and neuroticism.
Journal ArticleDOI
Functional topography of serotonergic systems supports the Deakin/Graeff hypothesis of anxiety and affective disorders.
TL;DR: It is argued that serotonergic neurons in the dorsal/caudal parts of the dorsal raphe nucleus project to forebrain limbic regions involved in stress/conflict anxiety-related processes, which may be relevant for anxiety and affective disorders.
References
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Journal Article
Validation and utility of a self-report version of PRIME-MD
Journal ArticleDOI
Integrating common and rare genetic variation in diverse human populations
David Altshuler,Richard A. Gibbs,Leena Peltonen,Emmanouil T. Dermitzakis,Stephen F. Schaffner,Fuli Yu,Penelope E. Bonnen,de Bakker Piw.,Panagiotis Deloukas,Stacey Gabriel,R. Gwilliam,Sarah E. Hunt,Michael Inouye,Xiaoming Jia,Aarno Palotie,Melissa Parkin,Pamela Whittaker,Kyle Chang,Alicia Hawes,Lora Lewis,Yanru Ren,D Wheeler,Donna M. Muzny,Chris P. Barnes,Katayoon Darvishi,Matthew E. Hurles,Joshua M. Korn,K. Kristiansson,Charles Lee,S A McCarrol,James Nemesh,Alon Keinan,Stephen B. Montgomery,Samuela Pollack,Alkes L. Price,Nicole Soranzo,Claudia Gonzaga-Jauregui,Verneri Anttila,Wendy Brodeur,Mark J. Daly,Stephen Leslie,Gil McVean,Loukas Moutsianas,Huy Nguyen,Qingrun Zhang,Ghori Mjr.,Ralph McGinnis,William M. McLaren,Fumihiko Takeuchi,Sharon R. Grossman,Ilya Shlyakhter,Elizabeth Hostetter,Pardis C. Sabeti,Clement Adebamowo,Morris W. Foster,Deborah R. Gordon,Julio Licinio,M C Manca,Patricia A. Marshall,Ichiro Matsuda,D Ngare,Vivian Ota Wang,D Reddy,Charles N. Rotimi,Charmaine D.M. Royal,Richard R. Sharp,Changqing Zeng,Lisa D. Brooks,Jean E. McEwen +68 more
TL;DR: An expanded public resource of genome variants in global populations supports deeper interrogation of genomic variation and its role in human disease, and serves as a step towards a high-resolution map of the landscape of human genetic variation.
Journal ArticleDOI
The Composite International Diagnostic Interview: An Epidemiologic Instrument Suitable for Use in Conjunction With Different Diagnostic Systems and in Different Cultures
Lee N. Robins,J. K. Wing,Hans-Ulrich Wittchen,John E. Helzer,Thomas F. Babor,J. D. Burke,Anne Farmer,Assen Jablenski,Roy W. Pickens,Darrel A. Regier,Norman Sartorius,Leland H. Towle +11 more
TL;DR: The design and development of the CIDI is described and the current field testing of a slightly reduced "core" version is described, allowing investigators reliably to assess mental disorders according to the most widely accepted nomenclatures in many different populations and cultures.
Journal ArticleDOI
Impaired Repression at a 5-Hydroxytryptamine 1A Receptor Gene Polymorphism Associated with Major Depression and Suicide
Sylvie Lemonde,Gustavo Turecki,David Bakish,Lisheng Du,Pavel D. Hrdina,Christopher D. Bown,Adolfo Sequeira,Neena Kushwaha,Stephen J. Morris,Ajoy Basak,Xiao-Ming Ou,Paul R. Albert +11 more
TL;DR: The data indicate that NUDR is a repressor of the 5-HT1A receptor in raphe cells the function of which is abrogated by a promoter polymorphism, suggesting a novel transcriptional model in which the G(-1019) allele derepresses 5- HT1A autoreceptor expression to reduce serotonergic neurotransmission, predisposing to depression and suicide.
Journal ArticleDOI
PET imaging of serotonin 1A receptor binding in depression
Wayne C. Drevets,Ellen Frank,Julie C. Price,David J. Kupfer,Daniel P. Holt,Phil J. Greer,Yiyun Huang,Clara Gautier,Chester A. Mathis +8 more
TL;DR: Serotonin-1A receptor BP is abnormally decreased in the depressed phase of familial mood disorders in multiple brain regions and may be associated with histopathological changes involving the raphe, convergence evidence from postmortem studies of mood disorders suggests.