Predictive Toxicology of Cobalt Nanoparticles and Ions: Comparative In Vitro Study of Different Cellular Models Using Methods of Knowledge Discovery from Data
Limor Horev-Azaria,Charles James Kirkpatrick,Rafi Korenstein,Patrice N. Marche,Oded Maimon,Jessica Ponti,Roni Romano,François Rossi,Ute Golla-Schindler,Dieter Sommer,Chiara Uboldi,Ronald E. Unger,Christian L. Villiers +12 more
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TLDR
The overall findings are in line with the hypothesis that the toxic effects of aggregated cobalt NPs are mainly due to cobalt ion dissolution from the aggregated NPs.About:
This article is published in Toxicological Sciences.The article was published on 2011-08-01 and is currently open access. It has received 108 citations till now. The article focuses on the topics: Cobalt.read more
Citations
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The use of cobalt chloride as a chemical hypoxia model.
TL;DR: A critical review about the scope and limitations of this widely used chemical hypoxia model is provided to be informative to all researchers interested in the field.
Journal ArticleDOI
Physical properties, biological applications and biocompatibility studies on biosynthesized single phase cobalt oxide (Co3O4) nanoparticles via Sageretia thea (Osbeck.)
Ali Talha Khalil,Ali Talha Khalil,Muhammad Ovais,Ikram Ullah,Muhammad Ali,Zabta Khan Shinwari,Zabta Khan Shinwari,Malik Maaza +7 more
TL;DR: The results indicate green synthesis as an alternative, effective and eco-friendly method for the biosynthesis of cobalt oxide nanoparticles with numerous biological applications.
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Predictive Toxicology of cobalt ferrite nanoparticles: comparative in-vitro study of different cellular models using methods of knowledge discovery from data
Limor Horev-Azaria,Giovanni Baldi,Delila Beno,Daniel Bonacchi,Ute Golla-Schindler,James Kirkpatrick,Susanne N. Kolle,Robert Landsiedel,Oded Maimon,Patrice N. Marche,Jessica Ponti,Roni Romano,François Rossi,Dieter Sommer,Chiara Uboldi,Ronald E. Unger,Christian L. Villiers,Rafi Korenstein +17 more
TL;DR: The observed correlation between the oxidative stress, caused by the presence of the Co-Fe NPs, with the hierarchy of sensitivity of the different cell types towards toxicity, suggests that oxidative stress is one possible mechanism for the toxicity of Co- Fe NPs.
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Comparative cytotoxicity of nanosilver in human liver HepG2 and colon Caco2 cells in culture.
Saura C. Sahu,Jiwen Zheng,Lesley Graham,Lynn Chen,John Ihrie,Jeffrey J. Yourick,Robert L. Sprando +6 more
TL;DR: The results suggest that cellular oxidative stress did not play a major role in the observed cytotoxicity of nanosilver in HepG2 and Caco2 cells and that a different mechanism of nanOSilver‐induced mitochondrial injury leads to the cytot toxicity.
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Spinel ferrite nanoparticles and nanocomposites for biomedical applications and their toxicity.
TL;DR: This review focuses on the biomedical applications and toxicity of spinel ferrite nanoparticles (SFNPs) with more emphasis on the recently published work and a critical review is provided on recent advances of SFNPs applications.
References
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Book
C4.5: Programs for Machine Learning
TL;DR: A complete guide to the C4.5 system as implemented in C for the UNIX environment, which starts from simple core learning methods and shows how they can be elaborated and extended to deal with typical problems such as missing data and over hitting.
Book
Data Mining: Practical Machine Learning Tools and Techniques
TL;DR: This highly anticipated third edition of the most acclaimed work on data mining and machine learning will teach you everything you need to know about preparing inputs, interpreting outputs, evaluating results, and the algorithmic methods at the heart of successful data mining.
Journal ArticleDOI
Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability.
François Denizot,Rita Lang +1 more
TL;DR: The reliability and sensitivity of the test have been increased to the point where it can in many cases replace the [3H]thymidine uptake assay to measure cell proliferation or survival in growth factor or cytotoxicity assays.
Journal ArticleDOI
Metals, toxicity and oxidative stress.
TL;DR: This review summarizes recent findings in the metal-induced formation of free radicals and the role of oxidative stress in the carcinogenicity and toxicity of metals.
Journal ArticleDOI
Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity
TL;DR: The identity of Alamar Blue is shown as resazurin, a very simple and versatile way of measuring cell proliferation and cytotoxicity that presents numerous advantages over other cytot toxicity or proliferation tests but there are several drawbacks to the routine use.