Predominance of a single genotype of Mycobacterium tuberculosis in countries of east Asia.
D. van Soolingen,Lishi Qian,P. E. W. De Haas,James T. Douglas,Hamidou Traore,Françoise Portaels,H. Z. Qing,D. Enkhsaikan,Pagbajabyn Nymadawa,J. D. A. Van Embden +9 more
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TLDR
Analysis of the population structure of Mycobacterium tuberculosis strains from the People's Republic of China showed that the vast majority belong to a genetically closely related group, which is designated the "Beijing family" of M. tuberculosis strains, indicating that strains of the Beijing family recently expanded from a single ancestor which had a selective advantage.Abstract:
Analysis of the population structure of Mycobacterium tuberculosis strains from the People's Republic of China showed that the vast majority belong to a genetically closely related group. These strains shared the majority of their IS6110 DNA-containing restriction fragments, and also, the DNA polymorphism associated with other repetitive DNA elements, like the polymorphic GC-rich sequence and the direct repeat, was very limited. Because the majority of these strains originated from the province of Beijing, we designated this grouping the "Beijing family" of M. tuberculosis strains. Strains of this family were also found to dominate in neighboring countries such as Mongolia, South Korea, and Thailand, whereas a low prevalence of such strains was observed in countries on other continents. These data indicate that strains of the Beijing family recently expanded from a single ancestor which had a selective advantage. It is speculated that long-term Mycobacterium bovis BCG vaccination may be one of the selective forces implicated in the successful spread of the Beijing genotype.read more
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Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology.
Judith Kamerbeek,Leo M. Schouls,Arend H. J. Kolk,M van Agterveld,D. van Soolingen,Sjoukje Kuijper,Annelies Bunschoten,H Molhuizen,R J Shaw,M Goyal,J. D. A. Van Embden +10 more
TL;DR: A novel method based on strain-dependent hybridization patterns of in vitro-amplified DNA with multiple spacer oligonucleotides was found to differentiate M. bovis from M. tuberculosis, a distinction which is often difficult to make by traditional methods.
Journal ArticleDOI
Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology
Karine Brudey,Jeffrey Driscoll,Leen Rigouts,Wolfgang M. Prodinger,Andrea Gori,Sahal Al-Hajoj,Caroline Allix,Liselotte Aristimuño,Jyoti Arora,Viesturs Baumanis,Lothar Binder,Patrícia Izquierdo Cafrune,Ángel Adrián Cataldi,Soonfatt Cheong,Roland Diel,Christopher Ellermeier,Jason T. Evans,Maryse Fauville-Dufaux,Séverine Ferdinand,Darío García de Viedma,Carlo Garzelli,Lidia Gazzola,Harrison Magdinier Gomes,M Cristina Guttierez,Peter M. Hawkey,Paul D. van Helden,Gurujaj V Kadival,Barry N. Kreiswirth,Kristin Kremer,Milan Kubin,Savita Kulkarni,Benjamin Liens,Troels Lillebaek,Ho Minh Ly,Carlos Martin,Christian Martin,Igor Mokrousov,Narvskaia Ov,Yun Fong Ngeow,Ludmilla Naumann,Stefan Niemann,Ida Parwati,Zeaur Rahim,Voahangy Rasolofo-Razanamparany,T. Rasolonavalona,M Lucia Rossetti,Sabine Rüsch-Gerdes,Anna Sajduda,Sofía Samper,Igor G Shemyakin,Urvashi B. Singh,Akos Somoskovi,Robin A. Skuce,Dick van Soolingen,Streicher Em,Philip Noel Suffys,Enrico Tortoli,Tatjana Tracevska,Véronique Vincent,Tommie C. Victor,Robin M. Warren,Sook Fan Yap,Khadiza Zaman,Françoise Portaels,Nalin Rastogi,Christophe Sola +65 more
TL;DR: The results suggests the existence of fine geographical genetic clines within MTC populations, that could mirror the passed and present Homo sapiens sapiens demographical and mycobacterial co-evolutionary history whose structure could be further reconstructed and modelled, thereby providing a large-scale conceptual framework of the global TB Epidemiologic Network.
Journal ArticleDOI
Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development
TL;DR: A strain selection framework is proposed, based on robust phylogenetic markers, which will allow for systematic and comprehensive evaluation of new tools for tuberculosis control and suggest strain-specific differences in virulence and immunogenicity.
Journal ArticleDOI
Automated High-Throughput Genotyping for Study of Global Epidemiology of Mycobacterium tuberculosis Based on Mycobacterial Interspersed Repetitive Units
TL;DR: Kremer et al. as mentioned in this paper used variable-number tandem repeat (VNTR) of genetic elements named mycobacterial interspersed repetitive units (MIRUs) in 12 mammalian minisatellite-like loci of M. tuberculosis.
Journal ArticleDOI
Comparison of Methods Based on Different Molecular Epidemiological Markers for Typing of Mycobacterium tuberculosis Complex Strains: Interlaboratory Study of Discriminatory Power and Reproducibility
Kristin Kremer,D. van Soolingen,Richard Frothingham,Walter H. Haas,Peter W. M. Hermans,Carlos Martin,Prasit Palittapongarnpim,Bonnie B. Plikaytis,Lee W. Riley,Mitchell A. Yakrus,James M. Musser,J. D. A. Van Embden +11 more
TL;DR: Strain differentiation by IS6110 RFLP or mixed-linker PCR are the methods of choice for epidemiological investigations, indicating a clonal population structure of M. tuberculosis strains.
References
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Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology.
J. D. A. Van Embden,M. D. Cave,Jack T. Crawford,J. W. Dale,K. D. Eisenach,B Gicquel,Peter W. M. Hermans,Carlos Martin,R. A. Mcadam,Thomas M. Shinnick +9 more
TL;DR: In this article, the authors proposed a standardized technique which exploits variability in both the number and genomic position of IS6110 to generate strain-specific patterns for DNA fingerprinting of Mycobacterium tuberculosis.
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An Outbreak of Tuberculosis With Accelerated Progression Among Persons Infected With the Human Immunodeficiency Virus. An Analysis Using Restriction-Fragment-Length Polymorphisms
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TL;DR: There should be heightened surveillance for tuberculosis in facilities where HIV-infected persons live, and investigation of contacts must be undertaken promptly and be focused more broadly than is usual.
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Occurrence and stability of insertion sequences in Mycobacterium tuberculosis complex strains: evaluation of an insertion sequence-dependent DNA polymorphism as a tool in the epidemiology of tuberculosis.
TL;DR: The results indicate that M. tuberculosis strains from regions in central Africa, where tuberculosis is highly prevalent, are generally more related to each other than isolates from the Netherlands, where the transmission rate is low and where the majority of the tuberculosis cases are presumed to be the result of reactivation of previously contracted M.culosis infections.
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An outbreak of multidrug-resistant tuberculosis among hospitalized patients with the acquired immunodeficiency syndrome.
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TL;DR: Multidrug-resistant tuberculosis is readily transmitted among hospitalized patients with AIDS and Physicians must be alert to this danger and must enforce adherence to the measures recommended to prevent nosocomial transmission of tuberculosis.
Journal ArticleDOI
Exogenous reinfection with multidrug-resistant Mycobacterium tuberculosis in patients with advanced HIV infection.
Peter M. Small,Robert W. Shafer,Philip C. Hopewell,Samir P. Singh,Mary J. Murphy,Ed Desmond,Marcelino F. Sierra,Gary K. Schoolnik +7 more
TL;DR: Resistance to antituberculous drugs can develop not only in the strain that caused the initial disease, but also as a result of reinfection with a new strain of M. tuberculosis that is drug-resistant.
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