Journal ArticleDOI
Prepulse inhibition in psychiatric disorders – Apart from schizophrenia
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TLDR
PPI is deficient in obsessive compulsive disorder (OCD) and Gilles de la Tourette's syndrome (GTS), and in bipolar disorder dysfunctional PPI seems to be rather state dependent.About:
This article is published in Journal of Psychiatric Research.The article was published on 2013-04-01. It has received 270 citations till now. The article focuses on the topics: Prepulse inhibition & Schizophrenia.read more
Citations
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Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia
Martha S. Windrem,Mikhail Osipovitch,Liu Zhengshan,Janna Bates,Devin Chandler-Militello,Lisa Zou,Jared Munir,Steven J. Schanz,Katherine McCoy,Robert H. Miller,Su Wang,Robert L. Findling,Paul J. Tesar,Steven A. Goldman,Steven A. Goldman +14 more
TL;DR: A causal role for impaired glial maturation in the development of schizophrenia is suggested and humanized glial chimeric mice are established to provide a humanized model for its in vivo assessment.
Journal ArticleDOI
Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice
Lissandra Castellan Baldan,Kyle A. Williams,Jean-Dominique Gallezot,Vladimir Pogorelov,Maximiliano Rapanelli,Michael J. Crowley,George M. Anderson,Erin Loring,Roxanne R Gorczyca,Eileen Billingslea,Suzanne Wasylink,Kaitlyn E. Panza,A. Gulhan Ercan-Sencicek,Kuakarun Krusong,Kuakarun Krusong,Bennett L. Leventhal,Bennett L. Leventhal,Hiroshi Ohtsu,Michael H. Bloch,Zoë A. Hughes,John H. Krystal,Linda C. Mayes,Ivan E. de Araujo,Yu-Shin Ding,Matthew W. State,Christopher Pittenger +25 more
TL;DR: Data confirm histidine decarboxylase deficiency as a rare cause of TS and identify HA-DA interactions in the basal ganglia as an important locus of pathology.
Journal ArticleDOI
Mechanisms of the anorexia of aging-a review.
TL;DR: The anorexia of aging is associated with protein-energy malnutrition, sarcopenia, frailty, functional deterioration, morbidity, and mortality and further studies on pathophysiological mechanisms should employ accurate measurement of body fat and lean mass.
Journal ArticleDOI
Age-related sperm DNA methylation changes are transmitted to offspring and associated with abnormal behavior and dysregulated gene expression
Maria H. Milekic,Yurong Xin,Anne H. O'Donnell,Kevin K. Kumar,M Bradley-Moore,Dolores Malaspina,Holly Moore,Daniela Brunner,Yongchao Ge,John R. Edwards,Stéphane Paul,Fatemeh Haghighi,Jay A. Gingrich +12 more
TL;DR: It is demonstrated that DNA methylation abnormalities arising in the sperm of old fathers are a plausible mechanism to explain some of the risks that APA poses to resulting offspring.
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Differential Susceptibility of the Developing Brain to Contextual Adversity and Stress
TL;DR: The assertion that differential susceptibility is inherently grounded within processes of biological moderation is concluded, as the interactive and adaptive product of genetic and environmental attributes.
References
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Journal ArticleDOI
Prestimulus Effects on Human Startle Reflex in Normals and Schizophrenics
TL;DR: When 20 normal subjects were compared to 12 schizophrenic subjects, significant differences in eyeblink response were found for blink amplitude and latency in the 60 msec prestimulus condition, which is consistent with information processing “overload” theories of sensory overstimulation in schizophrenia.
Journal ArticleDOI
The More or Less Startling Effects of Weak Prestimulation
TL;DR: It is proposed that, with the aid of physiological measures taken in the interval between lead and startle stimuli, this paradigm offers a promising method of investigating different levels of central processing and the operation of a short time-constant as opposed to a long time- constant system.
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Gating and habituation of the startle reflex in schizophrenic patients.
TL;DR: The results indicate that schizophrenic patients have extensive deficits in both intramodal and cross-modal sensorimotor gating and a trend to show acoustic startle habituation deficits.
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Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges.
TL;DR: The understanding of the neural regulation of PPI has increased tremendously over the past 15 years, and progress has come in "broad strokes", but a number of important details and complex questions remain to be addressed.
Journal ArticleDOI
A primary acoustic startle circuit: lesion and stimulation studies
TL;DR: The data suggest that a primary acoustic startle circuit in the rat consists of auditory nerve, ventral cochlear nucleus, nuclei of the lateral lemniscus, nucleus reticularis pontis caudalis, spinal interneuron, lower motor neuron, and muscles.