Journal ArticleDOI
Prognostic role of pretreatment blood neutrophil-to-lymphocyte ratio in advanced cancer survivors: A systematic review and meta-analysis of 66 cohort studies
Reads0
Chats0
TLDR
Overall, high pretreatment blood NLR could be an adverse prognostic indicator for advanced tumor and large-scale prospective studies investigating its survival outcomes in specific cancer type are strongly advocated.About:
This article is published in Cancer Treatment Reviews.The article was published on 2017-07-01. It has received 209 citations till now. The article focuses on the topics: Hazard ratio.read more
Citations
More filters
Journal ArticleDOI
Perioperative Predictive Markers for Recurrence of Esophageal Cancer after Esophagectomy.
Yoshinori Fujiwara,Masaharu Higashida,Hisako Kubota,Yuko Okamoto,Shumei Mineta,Shunji Endo,Tomio Ueno +6 more
TL;DR: In this article, the authors evaluated preoperative prognostic nutritional index (PNI), BMI, neutrophil-to-lymphocyte ratio (NLR), intraoperative blood loss, postoperative C-reactive protein (CRP) max, recurrence-free survival (RFS), and overall survival (OS) in patients who received esophagectomies.
Journal ArticleDOI
A nomogram incorporating PD-L1, NLR, and clinicopathologic features to predict inguinal lymph node metastasis in penile squamous cell carcinoma.
Jiao Hu,Huihuang Li,Tongchen He,Hao Deng,Guanghui Gong,Yu Cui,Peihua Liu,Wenbiao Ren,Chao Li,Jinbo Chen,Xiongbing Zu +10 more
TL;DR: A nomogram that incorporated tumor grade, lymphovascular invasion, PD-L1, and NLR that could be conveniently used to predict the preoperative individualized risk of inguinal LNM in patients with penile cancer is developed.
Journal ArticleDOI
Circulating Immune Cell Composition and Cancer Risk: A Prospective Study Using Epigenetic Cell Count Measures
Charlotte Le Cornet,Konstantin Schildknecht,Araceli Rossello Chornet,Renée T. Fortner,Sandra González Maldonado,Verena Katzke,Tilman Kühn,Theron Johnson,Sven Olek,Rudolf Kaaks +9 more
TL;DR: The results affirm the relevance of elevated FOXP3+ Tregs and lower levels of cytotoxic (CD8+) T cells as risk factors for tumor development.
Journal ArticleDOI
Immunotherapy in non-small-cell lung cancer: A bridge between research and clinical practice
TL;DR: The basis of immunogenicity and immune escape of cancer, with specific focus on non-small-cell lung cancer, mechanisms underlying immune checkpoint inhibitors efficacy and the most updated results on potential biomarkers are summarized.
Journal ArticleDOI
Efficacy outcomes and prognostic factors from real-world patients with advanced non-small-cell lung cancer treated with first-line chemoimmunotherapy: The Spinnaker retrospective study.
Giuseppe Luigi Banna,Ornella Cantale,Sethupathi R. Muthuramalingam,Judith Cave,Charles Comins,Alessio Cortellini,Alfredo Addeo,Alessio Signori,H Mckenzie,C. Escriu,Gloria Barone,Sam Chan,Alexander Hicks,H. Bainbridge,David J. Pinato,Christian H. Ottensmeier,Fabio Gomes +16 more
TL;DR: In this paper , the authors collected data from patients in six United Kingdom and one Swiss oncology centres with first-line pembrolizumab plus platinum-based chemotherapy.
References
More filters
Journal ArticleDOI
Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
Journal ArticleDOI
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Alessandro Liberati,Douglas G. Altman,Jennifer Tetzlaff,Cynthia D. Mulrow,Peter C Gøtzsche,John P. A. Ioannidis,Mike Clarke,Mike Clarke,Philip J. Devereaux,Jos Kleijnen,David Moher +10 more
TL;DR: An Explanation and Elaboration of the PRISMA Statement is presented and updated guidelines for the reporting of systematic reviews and meta-analyses are presented.
Journal ArticleDOI
Quantifying heterogeneity in a meta‐analysis
TL;DR: It is concluded that H and I2, which can usually be calculated for published meta-analyses, are particularly useful summaries of the impact of heterogeneity, and one or both should be presented in publishedMeta-an analyses in preference to the test for heterogeneity.
Book
Cochrane Handbook for Systematic Reviews of Interventions
Julian P T Higgins,Sally Green +1 more
TL;DR: The Cochrane Handbook for Systematic Reviews of Interventions is the official document that describes in detail the process of preparing and maintaining Cochrane systematic reviews on the effects of healthcare interventions.
Journal ArticleDOI
Operating characteristics of a rank correlation test for publication bias.
TL;DR: In this paper, an adjusted rank correlation test is proposed as a technique for identifying publication bias in a meta-analysis, and its operating characteristics are evaluated via simulations, and the test statistic is a direct statistical analogue of the popular funnel-graph.