Journal ArticleDOI
Prognostic role of pretreatment blood neutrophil-to-lymphocyte ratio in advanced cancer survivors: A systematic review and meta-analysis of 66 cohort studies
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TLDR
Overall, high pretreatment blood NLR could be an adverse prognostic indicator for advanced tumor and large-scale prospective studies investigating its survival outcomes in specific cancer type are strongly advocated.About:
This article is published in Cancer Treatment Reviews.The article was published on 2017-07-01. It has received 209 citations till now. The article focuses on the topics: Hazard ratio.read more
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The clinical implication of dynamic neutrophil to lymphocyte ratio and D-dimer in COVID-19: A retrospective study in Suzhou China.
TL;DR: The common COVID-19 abnormal hematological indexes on admission included hyperfibrinogenemia, lymphopenia, the elevation of D-dimer, and leuk Openia, which were significantly different between the mild/moderate and severe CO VID-19 groups.
Journal ArticleDOI
Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies
Meghan A Cupp,Margarita Cariolou,Ioanna Tzoulaki,Ioanna Tzoulaki,Dagfinn Aune,Dagfinn Aune,Evangelos Evangelou,Evangelos Evangelou,Antonio J. Berlanga-Taylor +8 more
TL;DR: Although the NLR and TAN hold clinical promise in their association with poor cancer prognosis, further research is required to provide robust evidence, assess causality and test clinical utility.
Journal ArticleDOI
Biomarkers for immune checkpoint inhibition in non–small cell lung cancer (NSCLC)
TL;DR: The authors review the biomarker PD‐L1 as well as other emerging and investigational tissue‐based and serum‐based markers that have potential to better predict responders to immunotherapy.
Journal ArticleDOI
Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio can predict clinical outcomes in patients with metastatic non-small-cell lung cancer treated with nivolumab.
Jingjing Liu,Shuang Li,Shuang Zhang,Ying Liu,Lixia Ma,Jing Zhu,Ying Xin,Ying Wang,Changliang Yang,Ying Cheng +9 more
TL;DR: Hematologic parameter such as systemic immune‐inflammation index (SII), neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to-lymphocytes ratio (PLR) is associated with nivolumab efficacy in advanced non‐small‐cell lung cancer (NSCLC).
Journal ArticleDOI
Exploring the prognostic value of the neutrophil-to-lymphocyte ratio in cancer
TL;DR: NLR may have greater prognostic value in patients with certain demographic and clinical features, after further characterization of populations in which NLR has maximum prognostic potential and the identification of meaningful thresholds for risk stratification.
References
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Journal ArticleDOI
Prognostic Role of NLR in Urinary Cancers: A Meta-Analysis
TL;DR: It is shown that NLR could act as a significant biomarker in the prognosis of urinary cancers and be a poor predictor for OS with HR of 1.81 and subgroup analyses revealed that high NLR yielded a worse OS in RCC.
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Pre-treatment neutrophil to lymphocyte ratio as a prognostic marker to predict chemotherapeutic response and survival outcomes in metastatic advanced gastric cancer
In Rae Cho,Jun Chul Park,Chan Hyuk Park,Jung Hyun Jo,Hyun Jik Lee,Sunyong Kim,Choong Nam Shim,Hyuk Lee,Sung Kwan Shin,Sang Kil Lee,Yong Chan Lee +10 more
TL;DR: Pretreatment NLR is a useful prognostic marker in patients with metastatic AGC who are undergoing palliative chemotherapy, and shows a significant association with PFS and overall survival.
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Effects of statins on cancer mortality and progression: A systematic review and meta-analysis of 95 cohorts including 1,111,407 individuals
TL;DR: A meta‐analysis of 55 articles showed that statin use was significantly associated with decreased risk of all‐cause mortality and recurrence‐free survival benefit for patients with malignancy, and associations almost remained consistent across those outcomes when stratified by publication type, tumour location, study design, sample size and initiation of statins.
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Neutrophil‐to‐lymphocyte ratio for predicting palliative chemotherapy outcomes in advanced pancreatic cancer patients
Peng Xue,Peng Xue,Masashi Kanai,Yukiko Mori,Takafumi Nishimura,Norimitsu Uza,Yuzo Kodama,Yoshiya Kawaguchi,Kyoichi Takaori,Shigemi Matsumoto,Shinji Uemoto,Tsutomu Chiba +11 more
TL;DR: The results support the idea that NLR can be a promising prognostic and predictive marker for APC patients receiving palliative chemotherapy.
Journal ArticleDOI
Pre-treatment lymphopenia as a prognostic biomarker in colorectal cancer patients receiving chemotherapy
Nicolas Ceze,G. Thibault,G. Thibault,G. Goujon,J. Viguier,Hervé Watier,Hervé Watier,Etienne Dorval,Thierry Lecomte +8 more
TL;DR: Findings show that lymphopenia is an independent predictive factor for both hematological toxicity and efficacy of chemotherapy in colorectal cancer patients, and pre-treatment lymphocyte count may represent a simple and new predictive biomarker of chemotherapy effects in colorean cancer patients.