Journal ArticleDOI
Prognostic role of pretreatment blood neutrophil-to-lymphocyte ratio in advanced cancer survivors: A systematic review and meta-analysis of 66 cohort studies
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TLDR
Overall, high pretreatment blood NLR could be an adverse prognostic indicator for advanced tumor and large-scale prospective studies investigating its survival outcomes in specific cancer type are strongly advocated.About:
This article is published in Cancer Treatment Reviews.The article was published on 2017-07-01. It has received 209 citations till now. The article focuses on the topics: Hazard ratio.read more
Citations
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Journal ArticleDOI
Associations between absolute neutrophil count and lymphocyte-predominant breast cancer.
Chang Ik Yoon,Soeun Park,Yoon Jin Cha,Hye Sun Lee,Soong June Bae,Chihwan Cha,Da Young Lee,Sung Gwe Ahn,Joon Jeong +8 more
TL;DR: Low peripheral ANC could be linked with LPBC, supporting the hypothesis that systemic immune cell counts might be associated with the tumor-immune microenvironment.
Journal ArticleDOI
The pretreatment neutrophil-lymphocyte ratio may predict prognosis of patients with liver cancer: A systematic review and meta-analysis
TL;DR: A meta‐analysis of 54 studies to evaluate the prognostic value of NLR was performed and it was found that the pretreatment neutrophil‐lymphocyte ratio may be associated with the prognosis of liver cancer.
Journal ArticleDOI
Meta-analysis of the prognostic value of the neutrophil-to-lymphocyte ratio in oral squamous cell carcinoma.
Yue Wang,Peng-Fei Wang,Oleh Andrukhov,Tingjian Wang,Si-Ying Song,Changxiang Yan,Fengqiu Zhang +6 more
TL;DR: A meta-analysis of studies investigating the association between NLR and survival in oral squamous cell carcinoma suggests a higher NLR is predictive of a poorer prognosis in OSCC.
Journal ArticleDOI
Methylation-derived Neutrophil-to-Lymphocyte Ratio and Lung Cancer Risk in Heavy Smokers.
Laurie Grieshober,Stefan Graw,Matthew J. Barnett,Mark D. Thornquist,Gary E. Goodman,Chu Chen,Chu Chen,Devin C. Koestler,Carmen J. Marsit,Jennifer A. Doherty,Jennifer A. Doherty +10 more
TL;DR: The relationship between prediagnosis mdNLR and lung cancer risk in a nested case–control study in the β-Carotene and Retinol Efficacy Trial of individuals at high risk for lung cancer due to heavy smoking or substantial occupational asbestos exposure is assessed.
Journal ArticleDOI
The Prognostic Value of Neutrophil-to-lymphocyte Ratio and Monocyte-to-lymphocyte Ratio in Metastatic Gastric Cancer Treated with Systemic Chemotherapy.
TL;DR: Elevated NLR and MLR were markedly related to the worse PFS1 and OS in mGC performed with first-line chemotherapy and in patients with second-line therapy, MLR was more closely connected to prognosis and was a significantly independent prognostic factor for PFS2.
References
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Journal ArticleDOI
Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
Journal ArticleDOI
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Alessandro Liberati,Douglas G. Altman,Jennifer Tetzlaff,Cynthia D. Mulrow,Peter C Gøtzsche,John P. A. Ioannidis,Mike Clarke,Mike Clarke,Philip J. Devereaux,Jos Kleijnen,David Moher +10 more
TL;DR: An Explanation and Elaboration of the PRISMA Statement is presented and updated guidelines for the reporting of systematic reviews and meta-analyses are presented.
Journal ArticleDOI
Quantifying heterogeneity in a meta‐analysis
TL;DR: It is concluded that H and I2, which can usually be calculated for published meta-analyses, are particularly useful summaries of the impact of heterogeneity, and one or both should be presented in publishedMeta-an analyses in preference to the test for heterogeneity.
Book
Cochrane Handbook for Systematic Reviews of Interventions
Julian P T Higgins,Sally Green +1 more
TL;DR: The Cochrane Handbook for Systematic Reviews of Interventions is the official document that describes in detail the process of preparing and maintaining Cochrane systematic reviews on the effects of healthcare interventions.
Journal ArticleDOI
Operating characteristics of a rank correlation test for publication bias.
TL;DR: In this paper, an adjusted rank correlation test is proposed as a technique for identifying publication bias in a meta-analysis, and its operating characteristics are evaluated via simulations, and the test statistic is a direct statistical analogue of the popular funnel-graph.