Journal ArticleDOI
Prognostic role of pretreatment blood neutrophil-to-lymphocyte ratio in advanced cancer survivors: A systematic review and meta-analysis of 66 cohort studies
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TLDR
Overall, high pretreatment blood NLR could be an adverse prognostic indicator for advanced tumor and large-scale prospective studies investigating its survival outcomes in specific cancer type are strongly advocated.About:
This article is published in Cancer Treatment Reviews.The article was published on 2017-07-01. It has received 209 citations till now. The article focuses on the topics: Hazard ratio.read more
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The clinical implication of dynamic neutrophil to lymphocyte ratio and D-dimer in COVID-19: A retrospective study in Suzhou China.
TL;DR: The common COVID-19 abnormal hematological indexes on admission included hyperfibrinogenemia, lymphopenia, the elevation of D-dimer, and leuk Openia, which were significantly different between the mild/moderate and severe CO VID-19 groups.
Journal ArticleDOI
Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies
Meghan A Cupp,Margarita Cariolou,Ioanna Tzoulaki,Ioanna Tzoulaki,Dagfinn Aune,Dagfinn Aune,Evangelos Evangelou,Evangelos Evangelou,Antonio J. Berlanga-Taylor +8 more
TL;DR: Although the NLR and TAN hold clinical promise in their association with poor cancer prognosis, further research is required to provide robust evidence, assess causality and test clinical utility.
Journal ArticleDOI
Biomarkers for immune checkpoint inhibition in non–small cell lung cancer (NSCLC)
TL;DR: The authors review the biomarker PD‐L1 as well as other emerging and investigational tissue‐based and serum‐based markers that have potential to better predict responders to immunotherapy.
Journal ArticleDOI
Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio can predict clinical outcomes in patients with metastatic non-small-cell lung cancer treated with nivolumab.
Jingjing Liu,Shuang Li,Shuang Zhang,Ying Liu,Lixia Ma,Jing Zhu,Ying Xin,Ying Wang,Changliang Yang,Ying Cheng +9 more
TL;DR: Hematologic parameter such as systemic immune‐inflammation index (SII), neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to-lymphocytes ratio (PLR) is associated with nivolumab efficacy in advanced non‐small‐cell lung cancer (NSCLC).
Journal ArticleDOI
Exploring the prognostic value of the neutrophil-to-lymphocyte ratio in cancer
TL;DR: NLR may have greater prognostic value in patients with certain demographic and clinical features, after further characterization of populations in which NLR has maximum prognostic potential and the identification of meaningful thresholds for risk stratification.
References
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Journal ArticleDOI
Tumour-infiltrating inflammation and prognosis in colorectal cancer: systematic review and meta-analysis.
Zubing Mei,Yingbin Liu,Chen-Ying Liu,Ang Cui,Zhonglin Liang,Guanghui Wang,H Peng,Long Cui,Cheng Li +8 more
TL;DR: Overall, high generalised tumour inflammatory infiltrate could be a good prognostic marker for CRC, however, significant heterogeneity and an insufficient number of studies underscore the need for further prospective studies on subsets of T lymphocytes to increase the robustness of the analyses.
Journal Article
Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes.
TL;DR: Peripheral blood granulocyte from normal healthy donors were found to reproducibly inhibit the cytolytic effector function of specifically sensitized cytotoxic T lymphocytes in vitro when co-incubated with these effector cells and target cells in 8 hr 51Cr release assays, suggesting that circulating granulocytes may have the potential for in vivo regulation of these cytot toxic effectors.
Journal ArticleDOI
Neutrophil to lymphocyte ratio (NLR) as an indicator of poor prognosis in stage IV non-small cell lung cancer
Susana Cedres,Susana Cedres,Davis Y. Torrejon,A. Martínez,A. Martínez,Pablo Martinez,Pablo Martinez,Alba Navarro,Esther Zamora,N. Mulet-Margalef,Enriqueta Felip +10 more
TL;DR: Elevated NLR is a predictor of shorter survival in patients with advanced NSCLC and the variation of NLR during the first cycle of treatment predicts survival, and it is found that patients with undifferentiated carcinoma and patients with NLR ≥5 had a worse survival.
Journal ArticleDOI
Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancer
Xin An,Pei Rong Ding,Yu Hong Li,Feng Hua Wang,Yan Xia Shi,Zhi Qiang Wang,You Jian He,Rui-Hua Xu,Wen Qi Jiang +8 more
TL;DR: Elevated NLR is a predictor of shorter survival in patients with advanced PC, and is identified as an independent prognostic factor for overall survival.
Journal ArticleDOI
Tumor-associated macrophages exhibit pro- and anti-inflammatory properties by which they impact on pancreatic tumorigenesis.
Ole Helm,Janka Held-Feindt,Evelin Grage-Griebenow,Norbert Reiling,Hendrik Ungefroren,Ilka Vogel,Uwe Krüger,Thomas Becker,Michael Ebsen,Christoph Röcken,Dieter Kabelitz,Heiner Schäfer,Susanne Sebens +12 more
TL;DR: Overall, these data demonstrate that TAMs exhibit anti‐ as well as proinflammatory properties that equally contribute to EMT induction in PDAC initiation and development.