Journal ArticleDOI
Prognostic role of pretreatment blood neutrophil-to-lymphocyte ratio in advanced cancer survivors: A systematic review and meta-analysis of 66 cohort studies
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TLDR
Overall, high pretreatment blood NLR could be an adverse prognostic indicator for advanced tumor and large-scale prospective studies investigating its survival outcomes in specific cancer type are strongly advocated.About:
This article is published in Cancer Treatment Reviews.The article was published on 2017-07-01. It has received 209 citations till now. The article focuses on the topics: Hazard ratio.read more
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The clinical implication of dynamic neutrophil to lymphocyte ratio and D-dimer in COVID-19: A retrospective study in Suzhou China.
TL;DR: The common COVID-19 abnormal hematological indexes on admission included hyperfibrinogenemia, lymphopenia, the elevation of D-dimer, and leuk Openia, which were significantly different between the mild/moderate and severe CO VID-19 groups.
Journal ArticleDOI
Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies
Meghan A Cupp,Margarita Cariolou,Ioanna Tzoulaki,Ioanna Tzoulaki,Dagfinn Aune,Dagfinn Aune,Evangelos Evangelou,Evangelos Evangelou,Antonio J. Berlanga-Taylor +8 more
TL;DR: Although the NLR and TAN hold clinical promise in their association with poor cancer prognosis, further research is required to provide robust evidence, assess causality and test clinical utility.
Journal ArticleDOI
Biomarkers for immune checkpoint inhibition in non–small cell lung cancer (NSCLC)
TL;DR: The authors review the biomarker PD‐L1 as well as other emerging and investigational tissue‐based and serum‐based markers that have potential to better predict responders to immunotherapy.
Journal ArticleDOI
Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio can predict clinical outcomes in patients with metastatic non-small-cell lung cancer treated with nivolumab.
Jingjing Liu,Shuang Li,Shuang Zhang,Ying Liu,Lixia Ma,Jing Zhu,Ying Xin,Ying Wang,Changliang Yang,Ying Cheng +9 more
TL;DR: Hematologic parameter such as systemic immune‐inflammation index (SII), neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to-lymphocytes ratio (PLR) is associated with nivolumab efficacy in advanced non‐small‐cell lung cancer (NSCLC).
Journal ArticleDOI
Exploring the prognostic value of the neutrophil-to-lymphocyte ratio in cancer
TL;DR: NLR may have greater prognostic value in patients with certain demographic and clinical features, after further characterization of populations in which NLR has maximum prognostic potential and the identification of meaningful thresholds for risk stratification.
References
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Journal ArticleDOI
Combination of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio is a useful prognostic factor in advanced non-small cell lung cancer patients.
TL;DR: The neutrophil to lymphocyte ratio (NLR) was recently shown to be a remarkable prognostic factor in tumors, but the combined prognostic value of NLR and PLR in non‐small cell lung cancer (NSCLC) is not clear.
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Prognostic value of neutrophil-to-lymphocyte ratio in advanced oesophago-gastric cancer: exploratory analysis of the REAL-2 trial
T. Grenader,T. Waddell,Clare Peckitt,Jacqui Oates,Naureen Starling,David Cunningham,John Bridgewater +6 more
TL;DR: It is confirmed that high NLR status had a significant negative prognostic effect in the REAL-2 trial population and this effect was independent of other known prognostic factors.
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Magnetic resonance imaging defined mucinous rectal carcinoma is an independent imaging biomarker for poor prognosis and poor response to preoperative chemoradiotherapy.
TL;DR: MRI diagnosis of mucinous adenocarcinoma is diagnostically superior to preoperative biopsy and occurs in up to 20% of rectal cancer patients and is an independent imaging biomarker for response to pre operative chemoradiotherapy (CRT) and prognosis.
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The relationship between nutritional status, inflammatory markers and survival in patients with advanced cancer: a prospective cohort study
TL;DR: Inflammatory markers were statistically associated with malnutrition and Malnutrition and mGPS were significant independent predictors of overall survival in patients with advanced cancer.
Journal ArticleDOI
High Neutrophil-to-lymphocyte Ratio Persistent During First-line Chemotherapy Predicts Poor Clinical Outcome in Patients with Advanced Urothelial Cancer
Lorena Rossi,Matteo Santoni,Simon J. Crabb,Emanuela Scarpi,Luciano Burattini,Caroline Chau,Emanuela Bianchi,Agnese Savini,Salvatore Luca Burgio,Alessandro Conti,Vincenza Conteduca,Stefano Cascinu,Ugo De Giorgi +12 more
TL;DR: An increased NLR persistent during first-line chemotherapy is an independent predictive factor for patients with advanced urothelial cancer.