Open AccessJournal Article
Progression Model for Pancreatic Cancer
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TLDR
A progression model for colorectal neoplasia was proposed in which it was hypothesized that the progression from normal colonic epithelium, to small adenomatous polyps, to infiltrating adenocarcinoma is associated with the activation.Abstract:
It has been >10 years since Vogelstein and colleagues [(1][1] [, 2)][2] proposed a progression model for colorectal neoplasia in which they hypothesized that the progression from normal colonic epithelium, to small adenomatous polyps, to infiltrating adenocarcinoma is associated with the activationread more
Citations
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Cancer genes and the pathways they control.
TL;DR: The purposes of this review are to highlight examples of progress in many areas of cancer research, indicate where knowledge is scarce and point out fertile grounds for future investigation.
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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Sunil R. Hingorani,Emanuel F. Petricoin,Anirban Maitra,Vinodh N. Rajapakse,Catrina King,Michael A. Jacobetz,Sally Ross,Thomas P. Conrads,Timothy D. Veenstra,Ben A. Hitt,Yoshiya Kawaguchi,Donald J. Johann,Lance A. Liotta,Howard C. Crawford,Mary E. Putt,Tyler Jacks,Christopher V.E. Wright,Ralph H. Hruban,Andrew M. Lowy,David A. Tuveson +19 more
TL;DR: It is found that physiological levels of Kras(G12D) induce ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs), putative precursors to invasive pancreatic cancer.
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Genetics and biology of pancreatic ductal adenocarcinoma
Haoqiang Ying,Prasenjit Dey,Wantong Yao,Alec C. Kimmelman,Giulio Draetta,Anirban Maitra,Ronald A. DePinho +6 more
TL;DR: The path to meaningful clinical progress has never been clearer to improve PDAC patient survival and a deeper understanding of cancer cell biology, particularly altered cancer cell metabolism and impaired DNA repair processes, is providing novel therapeutic strategies that show strong preclinical activity.
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An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms
Ralph H. Hruban,Kyoichi Takaori,David S. Klimstra,N. Volkan Adsay,Jorge Albores-Saavedra,Andrew V. Biankin,Sandra A. Biankin,Carolyn C. Compton,Noriyoshi Fukushima,Toru Furukawa,Michael Goggins,Yo Kato,Günter Klöppel,Daniel S. Longnecker,Jutta Lüttges,Anirban Maitra,G. Johan A. Offerhaus,Michio Shimizu,Suguru Yonezawa +18 more
TL;DR: The purpose of this meeting was to define an international acceptable set of diagnostic criteria for PanINs and IPMNs and to address a number of ambiguities that exist in the previously reported classification systems for these neoplasms.
References
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Journal ArticleDOI
Genetic alterations during colorectal-tumor development.
Bert Vogelstein,Eric R. Fearon,Stanley R. Hamilton,Scott E. Kern,Ann C. Preisinger,Mark Leppert,A M Smits,Johannes L. Bos +7 more
TL;DR: It is found that ras-gene mutations occurred in 58 percent of adenomas larger than 1 cm and in 47 percent of carcinomas, which are consistent with a model of colorectal tumorigenesis in which the steps required for the development of cancer often involve the mutational activation of an oncogene coupled with the loss of several genes that normally suppress tumors.
Journal ArticleDOI
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes.
Concepcion Almoguera,Darryl Shibata,Kathleen Forrester,John Martin,Norman Arnheim,Manuel Perucho +5 more
TL;DR: It is concluded that c-K-ras somatic mutational activation is a critical event in the oncogenesis of most, if not all, human cancers of the exocrine pancreas.
Journal ArticleDOI
APC mutations occur early during colorectal tumorigenesis.
Steven M. Powell,Nathan Zilz,Yasmin Beazer-Barclay,Tracy M. Bryan,Stanley R. Hamilton,Stephen N. Thibodeau,Bert Vogelstein,Kenneth W. Kinzler +7 more
TL;DR: Evidence is provided that mutations of the APC gene play a major role in the early development of colorectal neoplasms, and the frequency of such mutations remained constant as tumours progressed from benign to malignant stages.
Journal ArticleDOI
The multistep nature of cancer.
TL;DR: Three to six mutations appear to be required to complete the process of cellular multiplication associated with gradual increases in tumor size, disorganization and malignancy in cancer.
Journal ArticleDOI
Prevalence of ras gene mutations in human colorectal cancers
Johannes L. Bos,Matty Verlaan de Vries,Alex J. van der Eb,Eric R. Fearon,Bert Vogelstein,Stanley R. Hamilton,Jacques H. van Boom +6 more
TL;DR: A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.
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