Prolactin controls mammary gland development via direct and indirect mechanisms
Cathrin Brisken,Sarabjeet Kaur,Tony E. Chavarria,Nadine Binart,Robert L. Sutherland,Robert A. Weinberg,Paul A. Kelly,Christopher J. Ormandy +7 more
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TLDR
Prolactin affects mammary morphogenesis in two different ways: it controls ductal side branching and terminal end bud regression in virgin animals via indirect mechanisms, but acts directly on the mammary epithelium to produce lobuloalveolar development during pregnancy.About:
This article is published in Developmental Biology.The article was published on 1999-06-01 and is currently open access. It has received 346 citations till now. The article focuses on the topics: Prolactin receptor & Prolactin cell.read more
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Prolactin: Structure, Function, and Regulation of Secretion
TL;DR: The purpose of this review is to provide a comprehensive survey of the current understanding of prolactin's function and its regulation and to expose some of the controversies still existing.
Journal ArticleDOI
RANK-L and RANK: T Cells, Bone Loss, and Mammalian Evolution
TL;DR: Modulation of these systems provides a unique opportunity to design novel therapeutics to inhibit bone loss in arthritis, periodontal disease, and osteoporosis.
Journal ArticleDOI
Hormonal regulation of mammary differentiation and milk secretion.
TL;DR: Because a full-term pregnancy in early life is associated with a reduction in breast carcinogenesis, an understanding of the mechanisms by which these hormones bring about secretory differentiation may offer clues to the prevention of breast cancer.
Journal ArticleDOI
Mammary gland development
Hector Macias,Lindsay Hinck +1 more
TL;DR: The knowledge of mammary gland development and mammary stem cell biology has significantly contributed to the understanding of breast cancer and has advanced the discovery of therapies to treat this disease.
Journal ArticleDOI
The Role of Prolactin in Mammary Carcinoma
TL;DR: Findings indicate that antagonists of PRL/PRL receptor interaction or PRL receptor-associated signal transduction may be of considerable utility in the treatment of human breast cancer.
References
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Journal ArticleDOI
RAG-1-deficient mice have no mature B and T lymphocytes
Peter Mombaerts,John Iacomini,Randall S. Johnson,Karl Herrup,Susumu Tonegawa,Virginia E. Papaioannou +5 more
TL;DR: The introduction of a mutation in RAG-1 into the germline of mice via gene targeting in embryonic stem cells is described and it is shown that this mutation either activates or catalyzes the V(D)J recombination reaction of immunoglobulin and T cell receptor genes.
Journal Article
Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice.
TL;DR: This report presents three series of exper iments which fulfill the essential exper imenta l condit ions and which provide the desired direct evidence, and a new t r ansp lan ta t ion technic is described, which permi t s the t rAnsp lanTa t ion of normal, nodular, and tumorous m a m m a r y tissues into host m a n f rom hosts' fa t pads.
Journal ArticleDOI
Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse.
Christopher J. Ormandy,A Camus,J. Barra,Diane Damotte,B. Lucas,Hélène Buteau,Marc Edery,Nicole Brousse,Charles Babinet,Nadine Binart,Paul A. Kelly +10 more
TL;DR: This work establishes the prolactin receptor as a key regulator of mammalian reproduction, and provides the first total ablation model to further study the role of the prolACTin receptor and its ligands.
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Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene
Nelson D. Horseman,Wenzhu Zhao,Encarnacion Montecino-Rodriguez,Minoru Tanaka,Minoru Tanaka,Kunio Nakashima,Sandra J. Engle,Frost N. L. Smith,Edith Markoff,Kenneth Dorshkind +9 more
TL;DR: The results argue that PRL does not play any indispensable role in primary lymphocyte development and homeostasis, or in myeloid differentiation, and the PRL−/− mouse model provides a new research tool with which to resolve a variety of questions regarding the involvement of both endocrine and paracrine sources of PRL.
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An entire functional mammary gland may comprise the progeny from a single cell
Edith C. Kordon,Gilbert H. Smith +1 more
TL;DR: This study provides evidence that single multipotent stem cells positioned throughout the mature fully developed mammary gland have the capacity to produce sufficient differentiated progeny to recapitulate an entire functional gland.