Journal ArticleDOI
Protein Toxin Chaperoned by LRP-1-Targeted Virus-Mimicking Vesicles Induces High-Efficiency Glioblastoma Therapy In Vivo.
TLDR
It is reported that angiopep‐2‐directed and redox‐responsive virus‐mimicking polymersomes (ANG‐PS) can efficiently and selectively chaperone saporin (SAP), a highly potent natural protein toxin, to orthotopic human glioblastoma xenografts in nude mice.Abstract:
Glioblastoma is a most intractable and high-mortality malignancy because of its extremely low drug accessibility resulting from the blood-brain barrier (BBB). Here, it is reported that angiopep-2-directed and redox-responsive virus-mimicking polymersomes (ANG-PS) (angiopep-2 is a peptide targeting to low-density lipoprotein receptor-related protein-1 (LRP-1)) can efficiently and selectively chaperone saporin (SAP), a highly potent natural protein toxin, to orthotopic human glioblastoma xenografts in nude mice. Unlike chemotherapeutics, free SAP has a low cytotoxicity. SAP-loaded ANG-PS displays, however, a striking antitumor activity (half-maximal inhibitory concentration, IC50 = 30.2 × 10-9 m) toward U-87 MG human glioblastoma cells in vitro as well as high BBB transcytosis and glioblastoma accumulation in vivo. The systemic administration of SAP-loaded ANG-PS to U-87 MG orthotopic human-glioblastoma-bearing mice brings about little side effects, effective tumor inhibition, and significantly improved survival rate. The protein toxins chaperoned by LRP-1-targeted virus-mimicking vesicles emerge as a novel and highly promising treatment modality for glioblastoma.read more
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Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics
TL;DR: A comprehensive review on the latest remarkable advances in BBB-crossing nanotechnology, with an emphasis on the judicious design of multifunctional nanoplatforms for effective BBB penetration, efficient tumour accumulation, precise tumour imaging, and significant tumour inhibition of brain cancer.
Journal ArticleDOI
Ligand-Installed Nanocarriers toward Precision Therapy.
TL;DR: Recent advances regarding the development of ligand‐installed nanocarriers are introduced and the effect of their design on biological performance is discussed, with particular emphasis on their potential for emerging precision therapies.
Journal ArticleDOI
Polymers for cytosolic protein delivery.
TL;DR: Recent advances in the rational design of polymers for cytosolic delivery of native proteins with distinct isoelectric points and sizes are discussed and the possibility of developed polymers in the delivery of therapeutic proteins to treat diseases in vivo was evaluated.
Journal ArticleDOI
Overcoming blood–brain barrier transport: Advances in nanoparticle-based drug delivery strategies
Shichao Ding,Aminul Islam Khan,Xiaoli Cai,Yang Song,Zhaoyuan Lyu,Dan Du,Prashanta Dutta,Yuehe Lin +7 more
TL;DR: A general understanding is provided of how various properties of nanoparticles aid in drug delivery through BBB and usher the development of novel nanotechnology-based nanomaterials for cerebral disease therapies.
Journal Article
Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents
David Calligaris,Kalvis Hornburg,E. Antonio Chiocca,Nathalie Y. R. Agar,Sean E. Lawler,Choi-Fong Cho,Justin M. Wolfe,Colin M. Fadzen,Bradley L. Pentelute +8 more
TL;DR: In this paper, a self-assembling multicellular BBB spheroids display reproducible BBB features and functions, including high expression of tight junction proteins, VEGF-dependent permeability, efflux pump activity and receptor-mediated transcytosis of angiopep-2.
References
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