Prototypic Long Pentraxin PTX3 Is Present in Breast Milk, Spreads in Tissues, and Protects Neonate Mice from Pseudomonas aeruginosa Lung Infection
Sébastien Jaillon,Giuseppe Mancuso,Yveline Hamon,Yveline Hamon,Yveline Hamon,Céline Beauvillain,Viorica Cotici,Angelina Midiri,Barbara Bottazzi,Manuela Nebuloni,Cecilia Garlanda,Isabelle Frémaux,Isabelle Frémaux,Isabelle Frémaux,Jean François Gauchat,Philippe Descamps,Concetta Beninati,Alberto Mantovani,Pascale Jeannin,Yves Delneste +19 more
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TLDR
The results suggest that PTX3 might represent a therapeutic tool for treating neonatal infections and support the view that breastfeeding has beneficial effects on the neonates’ health.Abstract:
Newborns and infants present a higher susceptibility to infection than adults, a vulnerability associated with deficiencies in both the innate and adaptive immune systems. Innate immune receptors are sensors involved in the recognition and elimination of microbes that play a pivotal role at the interface between innate and adaptive immunity. Pentraxin 3 (PTX3), the prototypic long pentraxin, is a soluble pattern recognition receptor involved in the initiation of protective responses against selected pathogens. Because neonates are generally resistant to these pathogens, we suspected that PTX3 may be provided by a maternal source during the early life times. We observed that human colostrum contains high levels of PTX3, and that mammary epithelial cell and CD11b+ milk cells constitutively produce PTX3. Interestingly, PTX3 given orally to neonate mice was rapidly distributed in different organs, and PTX3 ingested during lactation was detected in neonates. Finally, we observed that orally administered PTX3 provided protection against Pseudomonas aeruginosa lung infection in neonate mice. Therefore, breastfeeding constitutes, during the early life times, an important source of PTX3, which actively participates in the protection of neonates against infections. In addition, these results suggest that PTX3 might represent a therapeutic tool for treating neonatal infections and support the view that breastfeeding has beneficial effects on the neonates’ health.read more
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The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling
Barbara Bottazzi,Antonio Inforzato,Massimo Messa,Marialuisa Barbagallo,Elena Magrini,Cecilia Garlanda,Alberto Mantovani +6 more
TL;DR: Pentraxins are a superfamily of fluid phase pattern recognition molecules conserved in evolution and characterized by a cyclic multimeric structure as discussed by the authors, and the long pentraxin 3 (PTX3) is the prototype of the long Pentraxin arm.
Journal ArticleDOI
PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer
TL;DR: Evidence suggests that PTX3 is a key homeostatic component at the crossroad of innate immunity, inflammation, tissue repair, and cancer.
Journal ArticleDOI
The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis.
Rémi Porte,Sadaf Davoudian,Fatemeh Asgari,Raffaella Parente,Alberto Mantovani,Alberto Mantovani,Cecilia Garlanda,Barbara Bottazzi +7 more
TL;DR: PTX3 acts as an important mediator of innate immunity against pathogens of fungal, bacterial and viral origin, and as a regulator of inflammation, by modulating complement activation and cell extravasation, and facilitating pathogen recognition by myeloid cells.
Journal ArticleDOI
The Dual Complexity of PTX3 in Health and Disease: A Balancing Act?
TL;DR: Dissection of such a yin-and-yang role of pentraxins in immunity and inflammation is timely and significant as it may pave the way for better clinical exploitation against various diseases.
Journal ArticleDOI
The long pentraxin PTX3 as a key component of humoral innate immunity and a candidate diagnostic for inflammatory diseases.
Sébastien Jaillon,Eduardo Bonavita,Stefania Gentile,Marcello Rubino,Ilaria Laface,Cecilia Garlanda,Alberto Mantovani +6 more
TL;DR: The general functions of pentraxins in innate immunity and inflammation are reviewed, focusing on the prototypic long pentraxin PTX3, which is highly conserved in evolution and produced by somatic and innate immune cells after proinflammatory stimuli.
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