Journal ArticleDOI
Psychometric validity of the 22-item Sinonasal Outcome Test.
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TLDR
The psychometric validation of a disease‐specific health related quality of life instrument for use in chronic rhinosinusitis is determined, the 22 item Sinonasal Outcome Test (SNOT‐22), a modification of a pre‐existing instrument, the SNOT‐20.Abstract:
Objectives: We set out to determine the psychometric validation of a disease-specific health related quality of life instrument for use in chronic rhinosinusitis, the 22 item Sinonasal Outcome Test (SNOT-22), a modification of a pre-existing instrument, the SNOT-20.
Design, setting and participants: The National Comparative Audit of Surgery for Nasal Polyposis and Chronic Rhinosinusitis was a prospective cohort study collecting data on 3128 adult patients undergoing sinonasal surgery in 87 NHS hospitals in England and Wales. Data were collected preoperatively and at 3 months after surgery, and analysed to determine validity of the SNOT-22. Test–retest reliability was assessed in a separate cohort of patients in a single centre.
Main outcome measures: The SNOT-22, a derivative of the SNOT-20 was the main outcome measure. Patients were also asked to report whether they felt better, the same or worse following surgery. To evaluate the SNOT-22, the internal consistency, responsiveness, known group differences and validity were analysed.
Results: Preoperative SNOT-22 scores were completed by 2803 patients. 3-month postoperative SNOT-22 scores were available for 2284 patients of all patients who completed a preoperative form (81.5% response rate). The Cronbach’s alpha scores for the SNOT-22 were 0.91 indicating high internal consistency. The test–retest reliability coefficient was 0.93, indicating high reliability of repeated measures. The SNOT-22 was able to discriminate between patients known to suffer with chronic rhinosinusitis and a group of healthy controls (P < 0.0001, t = 85.3). It was also able to identify statistically significant differences in sub-groups of patients with chronic rhinosinusitis. There was a statistically significant (P < 0.0001, t = 39.94) decrease in patient reported SNOT-22 scores at 3 months. At 3 months the overall effect size in all patients was 0.81, which is considered large. We found the minimally important difference that is the smallest change in SNOT-22 score that can be detected by a patient, to be 8.9 points.
Conclusions: We have found the SNOT-22 to be valid and easy to use. It can be used to facilitate routine clinical practice to highlight the impact of chronic rhinosinusitis on the patient’s quality of life, and may also be used to measure the outcome of surgical intervention. The minimally important difference allows us to interpret scores in a clinical context, and may help to improve patient selection for surgery.read more
Citations
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Journal ArticleDOI
European Position Paper on Rhinosinusitis and Nasal Polyps 2020
Wytske Fokkens,Valerie J. Lund,Joachim Mullol,Claus Bachert,Isam Alobid,Fuad M. Baroody,Noam A. Cohen,Anders Cervin,Richard Douglas,Philippe Gevaert,Christos Georgalas,Herman Goossens,Richard J. Harvey,Peter Hellings,Claire Hopkins,Nick Jones,Guy Joos,Livije Kalogjera,Bob Kern,Marek L. Kowalski,David Price,Herbert Riechelmann,Rodney J. Schlosser,Brent A. Senior,Mike Thomas,Elina Toskala,Richard Louis Voegels,De Yun Wang,Peter-John Wormald +28 more
TL;DR: The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012 and addresses areas not extensively covered in EPOS2012 such as paediatric CRS and sinus surgery.
Journal ArticleDOI
Dupilumab in persistent asthma with elevated eosinophil levels.
Sally E. Wenzel,Linda B. Ford,David S. Pearlman,Sheldon L. Spector,Lawrence Sher,Franck Skobieranda,Lin Wang,Stephane C. Kirkesseli,Ross E. Rocklin,Brian Bock,Jennifer D. Hamilton,Jeffrey Ming,Allen Radin,Neil Stahl,George D. Yancopoulos,Neil M.H. Graham,Gianluca Pirozzi +16 more
TL;DR: In patients with persistent, moderate-to-severe asthma and elevated eosinophil levels who used inhaled glucocorticoids and LABAs, dupilumab therapy, as compared with placebo, was associated with fewer asthma exacerbations when LABs and inhaled GLPAs were withdrawn, with improved lung function and reduced levels of Th2-associated inflammatory markers.
Journal ArticleDOI
Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials
Claus Bachert,Claus Bachert,Joseph K. Han,Martin Desrosiers,Peter Hellings,Nikhil Amin,Stella E. Lee,Joaquim Mullol,Leon S. Greos,John V. Bosso,Tanya M. Laidlaw,Anders Cervin,Jorge Maspero,Claire Hopkins,Heidi Olze,G. Walter Canonica,Pierluigi Paggiaro,Seong H. Cho,Wytske Fokkens,Shigeharu Fujieda,M. Zhang,Xin Lu,Chunpeng Fan,Steven Draikiwicz,Siddhesh Kamat,Asif Khan,Gianluca Pirozzi,Naimish Patel,Neil M.H. Graham,Marcella Ruddy,Heribert Staudinger,David M. Weinreich,Neil Stahl,George D. Yancopoulos,Leda Mannent +34 more
TL;DR: Dupilumab significantly improved the coprimary endpoints in both studies and was added to standard of care in adults with severe CRSwNP despite previous treatment with systemic corticosteroids, surgery, or both.
Journal ArticleDOI
International Consensus Statement on Allergy and Rhinology: Rhinosinusitis.
Richard R. Orlandi,Todd T. Kingdom,Peter H. Hwang,Tim Smith,Jeremiah A. Alt,Fuad M. Baroody,Pete S. Batra,Manuel Bernal-Sprekelsen,Neil Bhattacharyya,Rakesh K. Chandra,Alexander G. Chiu,Martin J. Citardi,Noam A. Cohen,John M. DelGaudio,Martin Desrosiers,Hun Jong Dhong,Richard G. Douglas,Berrylin J. Ferguson,Wytske Fokkens,Christos Georgalas,Andrew N. Goldberg,Jan Gosepath,Daniel L. Hamilos,Joseph K. Han,Richard J. Harvey,Peter Hellings,Claire Hopkins,Roger Jankowski,Amin R. Javer,Robert C. Kern,Stilianos E. Kountakis,Marek L. Kowalski,Andrew P. Lane,Donald C. Lanza,Richard A. Lebowitz,Heung Man Lee,Sandra Y. Lin,Valerie J. Lund,Amber U Luong,Wolf Mann,Bradley F. Marple,Kevin C. McMains,Ralph Metson,Robert M. Naclerio,Jayakar V. Nayak,Nobuyoshi Otori,James N. Palmer,Sanjay R. Parikh,Desiderio Passali,Anju T. Peters,Jay F. Piccirillo,David M. Poetker,Alkis J. Psaltis,Hassan H. Ramadan,Vijay R. Ramakrishnan,Herbert Riechelmann,Hwan Jung Roh,Luke Rudmik,Raymond Sacks,Rodney J. Schlosser,Brent A. Senior,Raj Sindwani,James A. Stankiewicz,Michael G. Stewart,Bruce K. Tan,Elina Toskala,Richard Louis Voegels,De Yun Wang,Erik K. Weitzel,Sarah K. Wise,Bradford A. Woodworth,Peter-John Wormald,Erin D. Wright,Bing Zhou,David W. Kennedy +74 more
TL;DR: This dissertation aims to provide a history of Chinese medical practice in the United States from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “modern China” began to circulate.
Journal ArticleDOI
Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial
Claus Bachert,Claus Bachert,Leda Mannent,Robert M. Naclerio,Joaquim Mullol,Berrylin J. Ferguson,Philippe Gevaert,Peter Hellings,Lixia Jiao,Ling Wang,Robert Evans,Gianluca Pirozzi,Neil M.H. Graham,Brian N. Swanson,Jennifer D. Hamilton,Allen Radin,Namita Gandhi,Neil Stahl,George D. Yancopoulos,E. Rand Sutherland +19 more
TL;DR: Among adults with symptomatic chronic sinusitis and nasal polyposis refractory to intranasal corticosteroids, the addition of subcutaneous dupilumab to mometasone furoate nasal spray compared with mometAsone alone reduced endoscopic nasal polyp burden after 16 weeks.
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