Open AccessJournal Article
Quantitative distribution and localization of calcitonin gene-related peptide-like cells in the stomach of two kidney, one clip rats.
TLDR
The aim of the present study was to examine the number and distribution of CGRP-containing cells in the pylorus of "two kidney, one clip" (2K1C) renovascular hypertension model in rats and the changes induced by hypertension in the neuroendocrine cells containing C GRP of the rats.Abstract:
The majority of research for the calcitonin gene-related peptide (CGRP) in the stomach in the hypertension has been devoted to the submucosal blood flow, and no attention has been paid to its quantitative distribution in the gastric neuroendocrine cells. The aim of the present study was to examine the number and distribution of CGRP-containing cells in the pylorus of "two kidney, one clip" (2K1C) renovascular hypertension model in rats. The studies were carried out on the stomach of rats. After 6 week period of the renal artery clipping procedure, eight 2K1C rats developed stable hypertension. The hypertension significantly increased the number of endocrine cells pylorus immunoreactive to calcitonin gene-related peptide (CGRP) antisera. The differences between the hypertensive rats and the control group concerned not only the number of endocrine cells but also their distribution. CGRP participates in the regulation of cardiovascular functions both in normal state and in the pathophysiology of hypertension through interactions with the prohypertensive systems. The changes induced by hypertension in the neuroendocrine cells containing CGRP of the rats are discussed.read more
Citations
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Changes in VIP-, SP- and CGRP- like immunoreactivity in intramural neurons within the pig stomach following supplementation with low and high doses of acrylamide.
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Evaluation of density and distribution of CART-immunoreactive structures in gastrointestinal tract of hypertensive rats.
Irena Kasacka,Żaneta Piotrowska +1 more
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Alterations of rat stomach endocrine cells under renovascular hypertension.
TL;DR: Investigations demonstrated the impact of renovascular hypertension on the neuroendocrine system in the rat stomach and changes in the total number and ultrastructure of DNES cells proved their undeniable role in the modulation of gastric dysfunction, as a consequence of deregulation of homeostasis-maintaining systems.
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Dynamics of calcitonin gene-related peptide-like cells changes in the lungs of two-kidney, one-clip rats.
Irena Kasacka,Ewa Arciszewska +1 more
TL;DR: It was revealed that renovascular hypertension caused changes in the neuroendocrine, CGRP-containing cells in the lungs of rats in the two-kidney, one-clip (2K1C) renov vascular hypertension model.
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Gastrointestinal neuroendocrine cells in various types of hypertension –a review
M. Niezgoda,I. Kasacka +1 more
TL;DR: Results obtained in many research studies indicate intense activity of enteroendocrine cells in the gastrointestinal tract in various pathological conditions, including hypertension.
References
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Journal ArticleDOI
Calcitonin Gene-Related Peptide and Its Receptors: Molecular Genetics, Physiology, Pathophysiology, and Therapeutic Potentials
TL;DR: This work has shown that alternative tissue-specific processing of primary mRNA from the α-CT/CGRP gene in rats generates two distinct peptides, CT and CGRP, which are the most potent endogenous vasodilatory peptides that have been discovered.
Journal ArticleDOI
The New Biology of Gastrointestinal Hormones
TL;DR: The new biology suggests that gastrointestinal hormones should be conceived as intercellular messengers of general physiological impact rather than as local regulators of the upper digestive tract.
Journal Article
Role of prostaglandins in gastroprotection and gastric adaptation.
TL;DR: Gastric adaptation appears to be long-lasting phenomenon accompanied by increased resistance of the adapted mucosa to subsequent damage induced by corrosive agents, unlike short lived gastroprotection by PG, NO, CGRP, mild irritants or short ischemia.
Journal Article
Basal and postprandial plasma levels of PYY, ghrelin, cholecystokinin, gastrin and insulin in women with moderate and morbid obesity and metabolic syndrome.
Krystyna Zwirska-Korczala,S J Konturek,M Sodowski,Mariusz Wylezol,Kuka D,Paweł Sowa,Monika Adamczyk-Sowa,Michał Kukla,Agnieszka Berdowska,J F Rehfeld,Władysław Bielański,T. Brzozowski +11 more
TL;DR: It is concluded that MS features of obesity are closely related to fasting and postprandial alterations of concentrations of PYY(3-36), CCK and ghrelin, suggesting that determination of gut hormones controlling food intake might be considered as a valuable tool to assess the progression of MS to comorbidities of obesity.
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